Evidence map›Paper›PMID 26606074›Full record

ArticlePloS one2015

Protective Effects of Dietary Supplementation with a Combination of Nutrients in a Transgenic Mouse Model of Alzheimer's Disease.

Shengyuan Wang, Yu Cui, Yu Cu, Chao Wang, Wei Xie, Lan Ma, Jinfeng Zhu, Yan Zhang, Rui Dang, Decai Wang and 2 more

Erratum issued Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT05172128 (Effect of Blueberry Supplementation on Alzheimer's Biomarkers), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05172128 nacompletednot on this mapstarted 2022, after this paper: background citation

Effect of Blueberry Supplementation on Alzheimer's Biomarkers

TypeinterventionalSponsorDuke UniversityRan2022 to 2023Enrolled12ConditionsMild Cognitive Impairment, Alzheimer DiseaseArmslyophilized blueberry supplement
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Inhibition of MiR-92a May Protect Endothelial Cells After Acute Myocardial Infarction in Rats: Role of KLF2/4.Medical science monitor : international medical journal of experimental and clinical research · 2016
    Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Shengyuan WangDepartment of Occupational Health, Public Health College, Harbin Medical University, Harbin, China.
Yu Cui
Yu CuDepartment of Social Medicine, Public Health College, Harbin Medical University, Harbin, China.
Chao WangDepartment of Nutrition, YanZhou people's hospital, YanZhou, China.
Wei XieDepartment of Nutrition and Food Hygiene, Public Health College, Harbin Medical University, Harbin, China.
Lan MaDepartment of Nutrition and Food Hygiene, Public Health College, Harbin Medical University, Harbin, China.
Jinfeng ZhuDepartment of Nutrition and Food Hygiene, Public Health College, Harbin Medical University, Harbin, China.
Yan ZhangDepartment of Nutrition and Food Hygiene, Public Health College, Harbin Medical University, Harbin, China.
Rui DangDepartment of Nutrition and Food Hygiene, Public Health College, Harbin Medical University, Harbin, China.
Decai WangDepartment of Nutrition and Food Hygiene, Public Health College, Harbin Medical University, Harbin, China.
Yonghui WuDepartment of Occupational Health, Public Health College, Harbin Medical University, Harbin, China.
Qunhong WuDepartment of Social Medicine, Public Health College, Harbin Medical University, Harbin, China.
Harbin Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study investigated the effects of intervention with a combination of nutrients in the amyloid precursor protein-presenilin (APP-PSN) C57BL/6J double transgenic mouse model of Alzheimer's disease (AD).

methodsA total of 72 2-month-old APP-PSN mice were randomly assigned to three groups. The model group (MG) was fed regular, unsupplemented chow, while the low- and high-dose treatment groups (LG and HG, respectively) were given a combination of nutrients that included phosphatidylserine, blueberry extracts, docosahexaenoic acid, and eicosapentaenoic acid as part of their diet. An additional 24 wild-type littermates that were fed unsupplemented chow served as the negative control group (NG). After 3 and 7 months of treatment, the cognitive performance was assessed with the Morris water maze and the shuttle box escape/avoidance task, and the biochemical parameters and oxidative stress were evaluated in both the blood and brain.

resultsAn improvement in antioxidant capacity was observed in the treatment groups relative to the MG at 3 months, while superior behavioral test results were observed in the mice of the HG and NG groups. In the MG, pycnosis was detected in neuronal nuclei, and a loss of neurons was observed in the cerebral cortex and the hippocampus. At 7 months, the β-amyloid1-42 peptide accumulation was significantly elevated in the MG but was markedly lower in the mice fed the nutrient combination. The antioxidant capacity and behavioral test scores were also higher in these mice.

conclusionsEarly intervention with a combination of nutrients should be considered as a strategy for preventing cognitive decline and other symptoms associated with AD.

Indexed as

Animal FeedDietary SupplementsAcetylcholineAlzheimer DiseaseAmyloid beta-Protein PrecursorAnimalsBehavior, AnimalBody WeightCholinesterasesDisease Models, AnimalMaze LearningMiceMice, Inbred C57BLMice, TransgenicOxidative StressPresenilinsAcetylcholineAmyloid beta-Protein PrecursorCholinesterasesPresenilins

Identifiers

PMID26606074
PMCPMC4659639
OpenAlexW2178528599

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.