ArticleEpidemiology (Cambridge, Mass.)2016
Association Between Particulate Air Pollution and QT Interval Duration in an Elderly Cohort.
Article in Epidemiology (Cambridge, Mass.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Characteristics of cohort studies of long-term exposure to PMEnvironmental science and pollution research international · 2019Pooled it
- Cardiac electrophysiological responses to traffic pollution in adults with or without chronic cardiopulmonary diseases.Environment international · 2025Article
- Long-term exposure to air pollution and incidence risk of various arrhythmias: A prospective cohort study.Eco-Environment & Health · 2024Article
- The association between air pollution and the daily hospital visits for atrial fibrillation recorded by ECG: a cross-sectional study.European journal of medical research · 2023Article
- Effect of particulate matter 2.5 on QT dispersion in patients with chronic respiratory disease.Scientific reports · 2022Article
- Associations between acute and long-term exposure to PM2.5 components and temperature with QT interval length in the VA Normative Aging Study.European journal of preventive cardiology · 2021Article
- Epigenetically mediated electrocardiographic manifestations of sub-chronic exposures to ambient particulate matter air pollution in the Women's Health Initiative and Atherosclerosis Risk in Communities Study.Environmental research · 2021Article
- Associations between PMEnvironmental research · 2021Article
- Oxidative stress and the cardiovascular effects of air pollution.Free radical biology & medicine · 2020Review
- Inhalation of printer-emitted particles impairs cardiac conduction, hemodynamics, and autonomic regulation and induces arrhythmia and electrical remodeling in rats.Particle and fibre toxicology · 2020Article
- Genomics of Particulate Matter Exposure Associated Cardiopulmonary Disease: A Narrative Review.International journal of environmental research and public health · 2019Review
- A review on heme oxygenase-1 induction: is it a necessary evil.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2018Review
- Cardiac pathophysiology in response to environmental stress: a current review.Current opinion in physiology · 2018Article
- Disease Modifiers of InheritedFrontiers in cardiovascular medicine · 2018Review
- Does air pollution contribute to travelers' illness and deaths?-evidence from a case report and need for further studies.Journal of travel medicine · 2018Article
- Cardiovascular effects of air pollution.Archives of cardiovascular diseases · 2017Review
- Editor's Highlight: Modifying Role of Endothelial Function Gene Variants on the Association of Long-Term PM2.5 Exposure With Blood DNA Methylation Age: The VA Normative Aging Study.Toxicological sciences : an official journal of the Society of Toxicology · 2017Article
- Genome-wide Association Study of Susceptibility to Particulate Matter-Associated QT Prolongation.Environmental health perspectives · 2017Article
- The mechanisms of air pollution and particulate matter in cardiovascular diseases.Heart failure reviews · 2017Review
- Air Pollution and Successful Aging: Recent Evidence and New Perspectives.Current environmental health reports · 2017Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundShort-term fine particulate matter (PM2.5) exposure has been linked with increased QT interval duration, a marker of ventricular repolarization and a risk factor for cardiac arrhythmia and sudden death, in several studies. Only one previous study evaluated whether long-term PM exposure is related to the QT interval. We aim to evaluate whether subchronic and long-term exposure to PM2.5 at home is linked with QT duration in an elderly cohort.
methodsWe measured heart-rate corrected QT interval duration among 404 participants from the Greater Boston area between 2003 and 2011. We modeled residential PM2.5 exposures using a hybrid satellite- and land use-based model. We evaluated associations between moving averages of short-term (1-2 days), subchronic (3-28 days), and long-term (1 year) pollutant exposures and corrected QT duration using linear mixed models. We also evaluated effect modification by oxidative stress genetic score using separated regression models and interaction terms.
resultsWe observed positive associations between subchronic and long-term PM2.5 exposure and corrected QT duration, with the strongest results for longer-term exposures. For example, a one standard deviation increase in 1-year PM2.5 was associated with a 6.3 ms increase in corrected QT (95% confidence interval: 1.8, 11). We observed somewhat greater effects among subjects with higher (8.5 ms) rather than lower (3.1 ms) oxidative stress allelic profiles (P interaction = 0.25).
conclusionsPM2.5 was associated with increased corrected QT duration in an elderly cohort. While most previous studies focused on short-term air pollution exposures, our results suggest that longer-term exposures are associated with cardiac repolarization.
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