Evidence map›Paper›PMID 26605491›Full record

ArticleACS applied materials & interfaces2015

Micro- and Nanopatterned Topographical Cues for Regulating Macrophage Cell Shape and Phenotype.

Thuy U Luu, Shannon C Gott, Bryan W K Woo, Masaru P Rao, Wendy F Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS applied materials & interfaces, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 146 papers.

0numbers the graph read from it
0cells of the map it votes in
146citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

146 citing papers in PubMed.

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  17. Extracellular matrix architecture promotes immunosuppressive microenvironments in pancreatic cancer.Matrix biology : journal of the International Society for Matrix Biology · 2025
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  19. Review
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86 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Thuy U LuuDepartment of Pharmacological Sciences, University of California at Irvine , Irvine, California 92697, United States.
Shannon C GottDepartment of Mechanical Engineering, University of California at Riverside , Riverside, California 92521, United States.
Bryan W K WooDepartment of Mechanical Engineering, University of California at Riverside , Riverside, California 92521, United States.
Masaru P RaoDepartment of Mechanical Engineering, University of California at Riverside , Riverside, California 92521, United States.
Wendy F LiuThe Edwards Lifesciences Center for Advanced Cardiovascular Technology, University of California at Irvine , Irvine, California 92697, United States.

Funding

Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Christine Hui · 1994 to 2026
$57.9M
Engineering Biomaterials to Exert Molecular Control of Immune Cell FunctionDP2DE023319 · NIDCR · UNIVERSITY OF CALIFORNIA-IRVINE · PI LIU, WENDY · 2012 to 2012
$2.3M
NCI NIH HHS P30 CA062203NIDCR NIH HHS DP2 DE023319NIDCR NIH HHS DP2DE023319
6 · The paper itself

Abstract

Controlling the interactions between macrophages and biomaterials is critical for modulating the response to implants. While it has long been thought that biomaterial surface chemistry regulates the immune response, recent studies have suggested that material geometry may in fact dominate. Our previous work demonstrated that elongation of macrophages regulates their polarization toward a pro-healing phenotype. In this work, we elucidate how surface topology might be leveraged to alter macrophage cell morphology and polarization state. Using a deep etch technique, we fabricated titanium surfaces containing micro- and nanopatterned grooves, which have been previously shown to promote cell elongation. Morphology, phenotypic markers, and cytokine secretion of murine bone marrow derived macrophages on different groove widths were analyzed. The results suggest that micro- and nanopatterned grooves influenced macrophage elongation, which peaked on substrates with 400-500 nm wide grooves. Surface grooves did not affect inflammatory activation but drove macrophages toward an anti-inflammatory, pro-healing phenotype. While secretion of TNF-alpha remained low in macrophages across all conditions, macrophages secreted significantly higher levels of anti-inflammatory cytokine, IL-10, on intermediate groove widths compared to cells on other Ti surfaces. Our findings highlight the potential of using surface topography to regulate macrophage function, and thus control the wound healing and tissue repair response to biomaterials.

Indexed as

AnimalsBiomarkersCells, CulturedCell ShapeCytokinesMacrophagesMiceMice, Inbred C57BLPhenotypeSurface PropertiesBiomarkersCytokinesbiocompatibilitygroovemacrophage polarizationtitaniumtopography

Identifiers

PMID26605491
PMCPMC4797644

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.