ArticleAnnals of translational medicine2015
Effectiveness of anisodamine for the treatment of critically ill patients with septic shock (ACIdoSIS study): study protocol for randomized controlled trial.
Registry-linked trialAbstract read
In one paragraph
Article in Annals of translational medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02442440 (Effectiveness of Anisodamine for the Treatment of Critically Ill Patients With Septic Shock), which is not on this map. Cited by 3 papers.
0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effectiveness of Anisodamine for the Treatment of Critically Ill Patients With Septic Shock: a Randomized Controlled Trial
Who cites it
3 citing papers in PubMed, 9 citations in OpenAlex.
- Case Report: Amiodarone-triggered refractory ventricular fibrillation storm in septic cardiomyopathy with pre-existing QT prolongation: termination using lidocaine and anisodamine.Frontiers in medicine · 2026Article
- Anisodamine microcirulatory effects in septic shock: be aware of cardiac side effects.Critical care (London, England) · 2021Article
- Effectiveness of enteral feeding protocol on clinical outcomes in critically ill patients: a study protocol for before-and-after design.Annals of translational medicine · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 1 institution in 1 country.
Zhongheng Zhang1 Department of Critical Care Medicine, Jinhua Municipal Central Hospital, Jinhua Hospital of Zhejiang University, Jinhua 321000, China ; 2 Department of Critical Care Medicine, Sir Run Run Shaw hospital, Zhejiang University School of Medicine, Hangzhou 310058, China ; 3 Department of Critical Care Medicine, Union Hospital, Tongji Medical Collegue, Huazhong University of Science and Technology, Wuhan 430022, China ; 4 Department of Critical Care Medicine, Binzhou People's Hospital of Shandong Province, Binzhou 256600, China ; 5 Department of Critical Care Medicine, Peace Hospital of Changzhi Medical College, the First Clinical College, Changzhi 046011, China ; 6 Department of Infection Control and Hospital Epidemiology, the First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China ; 7 Department of Critical Care Medicine, Lishui Municipal Central Hospital, Lishui 323000, China ; 8 Department of Critical Care Medicine, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200001, China ; 9 Department of Critical Care Medicine, the First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China.
Jiancang Zhou1 Department of Critical Care Medicine, Jinhua Municipal Central Hospital, Jinhua Hospital of Zhejiang University, Jinhua 321000, China ; 2 Department of Critical Care Medicine, Sir Run Run Shaw hospital, Zhejiang University School of Medicine, Hangzhou 310058, China ; 3 Department of Critical Care Medicine, Union Hospital, Tongji Medical Collegue, Huazhong University of Science and Technology, Wuhan 430022, China ; 4 Department of Critical Care Medicine, Binzhou People's Hospital of Shandong Province, Binzhou 256600, China ; 5 Department of Critical Care Medicine, Peace Hospital of Changzhi Medical College, the First Clinical College, Changzhi 046011, China ; 6 Department of Infection Control and Hospital Epidemiology, the First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China ; 7 Department of Critical Care Medicine, Lishui Municipal Central Hospital, Lishui 323000, China ; 8 Department of Critical Care Medicine, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200001, China ; 9 Department of Critical Care Medicine, the First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China.
You Shang1 Department of Critical Care Medicine, Jinhua Municipal Central Hospital, Jinhua Hospital of Zhejiang University, Jinhua 321000, China ; 2 Department of Critical Care Medicine, Sir Run Run Shaw hospital, Zhejiang University School of Medicine, Hangzhou 310058, China ; 3 Department of Critical Care Medicine, Union Hospital, Tongji Medical Collegue, Huazhong University of Science and Technology, Wuhan 430022, China ; 4 Department of Critical Care Medicine, Binzhou People's Hospital of Shandong Province, Binzhou 256600, China ; 5 Department of Critical Care Medicine, Peace Hospital of Changzhi Medical College, the First Clinical College, Changzhi 046011, China ; 6 Department of Infection Control and Hospital Epidemiology, the First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China ; 7 Department of Critical Care Medicine, Lishui Municipal Central Hospital, Lishui 323000, China ; 8 Department of Critical Care Medicine, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200001, China ; 9 Department of Critical Care Medicine, the First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China.
Xin'an Wang1 Department of Critical Care Medicine, Jinhua Municipal Central Hospital, Jinhua Hospital of Zhejiang University, Jinhua 321000, China ; 2 Department of Critical Care Medicine, Sir Run Run Shaw hospital, Zhejiang University School of Medicine, Hangzhou 310058, China ; 3 Department of Critical Care Medicine, Union Hospital, Tongji Medical Collegue, Huazhong University of Science and Technology, Wuhan 430022, China ; 4 Department of Critical Care Medicine, Binzhou People's Hospital of Shandong Province, Binzhou 256600, China ; 5 Department of Critical Care Medicine, Peace Hospital of Changzhi Medical College, the First Clinical College, Changzhi 046011, China ; 6 Department of Infection Control and Hospital Epidemiology, the First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China ; 7 Department of Critical Care Medicine, Lishui Municipal Central Hospital, Lishui 323000, China ; 8 Department of Critical Care Medicine, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200001, China ; 9 Department of Critical Care Medicine, the First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China.
Rui Yin1 Department of Critical Care Medicine, Jinhua Municipal Central Hospital, Jinhua Hospital of Zhejiang University, Jinhua 321000, China ; 2 Department of Critical Care Medicine, Sir Run Run Shaw hospital, Zhejiang University School of Medicine, Hangzhou 310058, China ; 3 Department of Critical Care Medicine, Union Hospital, Tongji Medical Collegue, Huazhong University of Science and Technology, Wuhan 430022, China ; 4 Department of Critical Care Medicine, Binzhou People's Hospital of Shandong Province, Binzhou 256600, China ; 5 Department of Critical Care Medicine, Peace Hospital of Changzhi Medical College, the First Clinical College, Changzhi 046011, China ; 6 Department of Infection Control and Hospital Epidemiology, the First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China ; 7 Department of Critical Care Medicine, Lishui Municipal Central Hospital, Lishui 323000, China ; 8 Department of Critical Care Medicine, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200001, China ; 9 Department of Critical Care Medicine, the First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China.
Zhenhua Zhu1 Department of Critical Care Medicine, Jinhua Municipal Central Hospital, Jinhua Hospital of Zhejiang University, Jinhua 321000, China ; 2 Department of Critical Care Medicine, Sir Run Run Shaw hospital, Zhejiang University School of Medicine, Hangzhou 310058, China ; 3 Department of Critical Care Medicine, Union Hospital, Tongji Medical Collegue, Huazhong University of Science and Technology, Wuhan 430022, China ; 4 Department of Critical Care Medicine, Binzhou People's Hospital of Shandong Province, Binzhou 256600, China ; 5 Department of Critical Care Medicine, Peace Hospital of Changzhi Medical College, the First Clinical College, Changzhi 046011, China ; 6 Department of Infection Control and Hospital Epidemiology, the First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China ; 7 Department of Critical Care Medicine, Lishui Municipal Central Hospital, Lishui 323000, China ; 8 Department of Critical Care Medicine, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200001, China ; 9 Department of Critical Care Medicine, the First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China.
Wensen Chen1 Department of Critical Care Medicine, Jinhua Municipal Central Hospital, Jinhua Hospital of Zhejiang University, Jinhua 321000, China ; 2 Department of Critical Care Medicine, Sir Run Run Shaw hospital, Zhejiang University School of Medicine, Hangzhou 310058, China ; 3 Department of Critical Care Medicine, Union Hospital, Tongji Medical Collegue, Huazhong University of Science and Technology, Wuhan 430022, China ; 4 Department of Critical Care Medicine, Binzhou People's Hospital of Shandong Province, Binzhou 256600, China ; 5 Department of Critical Care Medicine, Peace Hospital of Changzhi Medical College, the First Clinical College, Changzhi 046011, China ; 6 Department of Infection Control and Hospital Epidemiology, the First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China ; 7 Department of Critical Care Medicine, Lishui Municipal Central Hospital, Lishui 323000, China ; 8 Department of Critical Care Medicine, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200001, China ; 9 Department of Critical Care Medicine, the First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China.
Xin Tian1 Department of Critical Care Medicine, Jinhua Municipal Central Hospital, Jinhua Hospital of Zhejiang University, Jinhua 321000, China ; 2 Department of Critical Care Medicine, Sir Run Run Shaw hospital, Zhejiang University School of Medicine, Hangzhou 310058, China ; 3 Department of Critical Care Medicine, Union Hospital, Tongji Medical Collegue, Huazhong University of Science and Technology, Wuhan 430022, China ; 4 Department of Critical Care Medicine, Binzhou People's Hospital of Shandong Province, Binzhou 256600, China ; 5 Department of Critical Care Medicine, Peace Hospital of Changzhi Medical College, the First Clinical College, Changzhi 046011, China ; 6 Department of Infection Control and Hospital Epidemiology, the First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China ; 7 Department of Critical Care Medicine, Lishui Municipal Central Hospital, Lishui 323000, China ; 8 Department of Critical Care Medicine, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200001, China ; 9 Department of Critical Care Medicine, the First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China.
Yuetian Yu1 Department of Critical Care Medicine, Jinhua Municipal Central Hospital, Jinhua Hospital of Zhejiang University, Jinhua 321000, China ; 2 Department of Critical Care Medicine, Sir Run Run Shaw hospital, Zhejiang University School of Medicine, Hangzhou 310058, China ; 3 Department of Critical Care Medicine, Union Hospital, Tongji Medical Collegue, Huazhong University of Science and Technology, Wuhan 430022, China ; 4 Department of Critical Care Medicine, Binzhou People's Hospital of Shandong Province, Binzhou 256600, China ; 5 Department of Critical Care Medicine, Peace Hospital of Changzhi Medical College, the First Clinical College, Changzhi 046011, China ; 6 Department of Infection Control and Hospital Epidemiology, the First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China ; 7 Department of Critical Care Medicine, Lishui Municipal Central Hospital, Lishui 323000, China ; 8 Department of Critical Care Medicine, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200001, China ; 9 Department of Critical Care Medicine, the First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China.
Xiangrong Zuo1 Department of Critical Care Medicine, Jinhua Municipal Central Hospital, Jinhua Hospital of Zhejiang University, Jinhua 321000, China ; 2 Department of Critical Care Medicine, Sir Run Run Shaw hospital, Zhejiang University School of Medicine, Hangzhou 310058, China ; 3 Department of Critical Care Medicine, Union Hospital, Tongji Medical Collegue, Huazhong University of Science and Technology, Wuhan 430022, China ; 4 Department of Critical Care Medicine, Binzhou People's Hospital of Shandong Province, Binzhou 256600, China ; 5 Department of Critical Care Medicine, Peace Hospital of Changzhi Medical College, the First Clinical College, Changzhi 046011, China ; 6 Department of Infection Control and Hospital Epidemiology, the First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China ; 7 Department of Critical Care Medicine, Lishui Municipal Central Hospital, Lishui 323000, China ; 8 Department of Critical Care Medicine, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200001, China ; 9 Department of Critical Care Medicine, the First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China.
Kun Chen1 Department of Critical Care Medicine, Jinhua Municipal Central Hospital, Jinhua Hospital of Zhejiang University, Jinhua 321000, China ; 2 Department of Critical Care Medicine, Sir Run Run Shaw hospital, Zhejiang University School of Medicine, Hangzhou 310058, China ; 3 Department of Critical Care Medicine, Union Hospital, Tongji Medical Collegue, Huazhong University of Science and Technology, Wuhan 430022, China ; 4 Department of Critical Care Medicine, Binzhou People's Hospital of Shandong Province, Binzhou 256600, China ; 5 Department of Critical Care Medicine, Peace Hospital of Changzhi Medical College, the First Clinical College, Changzhi 046011, China ; 6 Department of Infection Control and Hospital Epidemiology, the First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China ; 7 Department of Critical Care Medicine, Lishui Municipal Central Hospital, Lishui 323000, China ; 8 Department of Critical Care Medicine, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200001, China ; 9 Department of Critical Care Medicine, the First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China.
Xuqing Ji1 Department of Critical Care Medicine, Jinhua Municipal Central Hospital, Jinhua Hospital of Zhejiang University, Jinhua 321000, China ; 2 Department of Critical Care Medicine, Sir Run Run Shaw hospital, Zhejiang University School of Medicine, Hangzhou 310058, China ; 3 Department of Critical Care Medicine, Union Hospital, Tongji Medical Collegue, Huazhong University of Science and Technology, Wuhan 430022, China ; 4 Department of Critical Care Medicine, Binzhou People's Hospital of Shandong Province, Binzhou 256600, China ; 5 Department of Critical Care Medicine, Peace Hospital of Changzhi Medical College, the First Clinical College, Changzhi 046011, China ; 6 Department of Infection Control and Hospital Epidemiology, the First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China ; 7 Department of Critical Care Medicine, Lishui Municipal Central Hospital, Lishui 323000, China ; 8 Department of Critical Care Medicine, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200001, China ; 9 Department of Critical Care Medicine, the First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China.
Hongying Ni1 Department of Critical Care Medicine, Jinhua Municipal Central Hospital, Jinhua Hospital of Zhejiang University, Jinhua 321000, China ; 2 Department of Critical Care Medicine, Sir Run Run Shaw hospital, Zhejiang University School of Medicine, Hangzhou 310058, China ; 3 Department of Critical Care Medicine, Union Hospital, Tongji Medical Collegue, Huazhong University of Science and Technology, Wuhan 430022, China ; 4 Department of Critical Care Medicine, Binzhou People's Hospital of Shandong Province, Binzhou 256600, China ; 5 Department of Critical Care Medicine, Peace Hospital of Changzhi Medical College, the First Clinical College, Changzhi 046011, China ; 6 Department of Infection Control and Hospital Epidemiology, the First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China ; 7 Department of Critical Care Medicine, Lishui Municipal Central Hospital, Lishui 323000, China ; 8 Department of Critical Care Medicine, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200001, China ; 9 Department of Critical Care Medicine, the First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China.
Anisodamine Critically Ill SeptIc Shock (ACIdoSIS) study group
Jinhua Central Hospital · CN
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSeptic shock is an important contributor of mortality in the intensive care unit (ICU). Although strenuous effort has been made to improve its outcome, the mortality rate is only marginally decreased. The present study aimed to investigate the effectiveness of anisodamine in the treatment of septic shock, in the hope that the drug will provide alternatives to the treatment of septic shock.
methodsThe study is a multi-center randomized controlled clinical trial. Study population will include critically ill patients with septic shock requiring vasopressor use. Blocked randomization was performed where anisodamine and control treatments were allocated at random in a ratio of 1:1 in blocks of sizes 2, 4, 6, 8, and 10 to 354 subjects. Interim analysis will be performed. The primary study end point is the hospital mortality, and other secondary study endpoints include ICU mortality, length of stay in ICU and hospital, organ failure free days. Adverse events including new onset psychosis, urinary retention, significant hypotension and tachycardia will be reported. DISCUSSION: The study will provide new insight into the treatment of septic shock and can help to reduce mortality rate of septic shock.
trial registrationNCT02442440 (https://register.clinicaltrials.gov/).
Indexed as
Anisodamineintensive care unit (ICU)mortalityrandomized controlled trialseptic shock
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Registered trials
NCT02442440ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.