Evidence map›Paper›PMID 26605290›Full record

ArticleAnnals of translational medicine2015

Extended leukocyte differential count and C-reactive protein in septic patients with liver impairment: diagnostic approach to evaluate sepsis in intensive care unit.

Sabrina Buoro, Tommaso Mecca, Giovanna Azzarà, Sara Apassiti Esposito, Michela Seghezzi, Mauro Vavassori, Alberto Crippa, Gianmariano Marchesi, Enrico Castellucci, Cosimo Ottomano and 1 more

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Article in Annals of translational medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.4field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Evaluation of Immature Granulocyte Count as the Earliest Biomarker for Sepsis.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2022
    Article
  3. Article
  4. Article
  5. Article
  6. Is Immature Granulocyte Count a Potential Prognostic Marker for Upper Gastrointestinal Tract Bleeding? A New Road to Explore.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2020
    Article
  7. The complete blood count to diagnose septic shock.Journal of thoracic disease · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Sabrina Buoro1 Laboratory of Clinical Chemistry, 2 Intensive Care Unit, 3 Department of Urology, Hospital Papa Giovanni XXIII, Bergamo, Italy ; 4 CAM Laboratory S.p.A., Monza, Italy ; 5 Section of Clinical Biochemistry, University of Verona, Verona, Italy.
Tommaso Mecca1 Laboratory of Clinical Chemistry, 2 Intensive Care Unit, 3 Department of Urology, Hospital Papa Giovanni XXIII, Bergamo, Italy ; 4 CAM Laboratory S.p.A., Monza, Italy ; 5 Section of Clinical Biochemistry, University of Verona, Verona, Italy.
Giovanna Azzarà1 Laboratory of Clinical Chemistry, 2 Intensive Care Unit, 3 Department of Urology, Hospital Papa Giovanni XXIII, Bergamo, Italy ; 4 CAM Laboratory S.p.A., Monza, Italy ; 5 Section of Clinical Biochemistry, University of Verona, Verona, Italy.
Sara Apassiti Esposito1 Laboratory of Clinical Chemistry, 2 Intensive Care Unit, 3 Department of Urology, Hospital Papa Giovanni XXIII, Bergamo, Italy ; 4 CAM Laboratory S.p.A., Monza, Italy ; 5 Section of Clinical Biochemistry, University of Verona, Verona, Italy.
Michela Seghezzi1 Laboratory of Clinical Chemistry, 2 Intensive Care Unit, 3 Department of Urology, Hospital Papa Giovanni XXIII, Bergamo, Italy ; 4 CAM Laboratory S.p.A., Monza, Italy ; 5 Section of Clinical Biochemistry, University of Verona, Verona, Italy.
Mauro Vavassori1 Laboratory of Clinical Chemistry, 2 Intensive Care Unit, 3 Department of Urology, Hospital Papa Giovanni XXIII, Bergamo, Italy ; 4 CAM Laboratory S.p.A., Monza, Italy ; 5 Section of Clinical Biochemistry, University of Verona, Verona, Italy.
Alberto Crippa1 Laboratory of Clinical Chemistry, 2 Intensive Care Unit, 3 Department of Urology, Hospital Papa Giovanni XXIII, Bergamo, Italy ; 4 CAM Laboratory S.p.A., Monza, Italy ; 5 Section of Clinical Biochemistry, University of Verona, Verona, Italy.
Gianmariano Marchesi1 Laboratory of Clinical Chemistry, 2 Intensive Care Unit, 3 Department of Urology, Hospital Papa Giovanni XXIII, Bergamo, Italy ; 4 CAM Laboratory S.p.A., Monza, Italy ; 5 Section of Clinical Biochemistry, University of Verona, Verona, Italy.
Enrico Castellucci1 Laboratory of Clinical Chemistry, 2 Intensive Care Unit, 3 Department of Urology, Hospital Papa Giovanni XXIII, Bergamo, Italy ; 4 CAM Laboratory S.p.A., Monza, Italy ; 5 Section of Clinical Biochemistry, University of Verona, Verona, Italy.
Cosimo Ottomano1 Laboratory of Clinical Chemistry, 2 Intensive Care Unit, 3 Department of Urology, Hospital Papa Giovanni XXIII, Bergamo, Italy ; 4 CAM Laboratory S.p.A., Monza, Italy ; 5 Section of Clinical Biochemistry, University of Verona, Verona, Italy.
Giuseppe Lippi1 Laboratory of Clinical Chemistry, 2 Intensive Care Unit, 3 Department of Urology, Hospital Papa Giovanni XXIII, Bergamo, Italy ; 4 CAM Laboratory S.p.A., Monza, Italy ; 5 Section of Clinical Biochemistry, University of Verona, Verona, Italy.
Ospedale Papa Giovanni XXIII · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSepsis is still a major cause of death in intensive care units (ICUs) worldwide. Patients with liver impairment express an imbalanced cytokine response which alters common sepsis biphasic nature. Cytokines measurement is expensive, often unavailable, whereas leukocytes (WBC) evaluation performed through hematology analyzers can provide a practical strategy for monitoring inflammatory response.

methodsA total of 200 healthy subjects (HS) and 84 patients (18 with, 66 without liver impairment) admitted to ICU, were assessed for International Sepsis Definitions, Sequential Organ Failure Assessment (SOFA) and Model for End-Stage Liver Disease (MELD) scores. We tested 1,022 peripheral blood samples using Sysmex XN-9000, estimating diagnostic accuracy of leukocyte differential count and nontraditional parameters through receiver operating characteristics (ROC) curves analysis compared to clinical classification.

resultsMedian value of all-leukocyte parameters was different in ICU patients compared to HS. Leukocytes, neutrophils (NE) and immature granulocytes (IGs) in sepsis and septic shock (SS) were higher than no sepsis (NS), with an area under the curve: 0.81, 0.82 and 0.78 respectively. Lymphocytes (LY) and monocytes (MO) were significantly associated with liver impairment.

conclusionsDiagnostic accuracy of all-leukocyte parameters may provide valuable information for diagnosis and follow-up of sepsis in ICU patients, especially those with liver impairment.

Indexed as

C-reactive protein (CRP)differential leukocyte countliver diseasesepsis

Identifiers

PMID26605290
PMCPMC4620099
OpenAlexW2102809650

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.