ArticleAdvanced biomedical research2015
The relation between serum Vitamin D levels and body antioxidant status in ischemic stroke patients: A case-control study.
Article in Advanced biomedical research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 26 citations in OpenAlex.
- Prevalence of vitamin D deficiency and its association with cardiometabolic risk factors among healthcare workers in the Eastern Cape province, South Africa; cross-sectional study.Scientific reports · 2024Article
- Review
- The combined presence of hypertension and vitamin D deficiency increased the probability of the occurrence of small vessel disease in China.BMC neurology · 2019Article
- Vitamin D and alopecia areata: possible roles in pathogenesis and potential implications for therapy.American journal of translational research · 2019Review
- Relationship between serum vitamin D levels and inflammatory markers in acute stroke patients.Brain and behavior · 2018Article
- Low levels of Vitamin D an emerging risk for cardiovascular diseases: A review.International journal of health sciencesReview
- Can Vitamin D and L-Cysteine Co-Supplementation Reduce 25(OH)-Vitamin D Deficiency and the Mortality Associated with COVID-19 in African Americans?Journal of the American College of NutritionArticle
- The Association Between Inflammatory Biomarkers and Vitamin D Level With the Evolution and Severity of Stroke.Basic and clinical neuroscienceArticle
- Dietary patterns change over two years in early adolescent girls in Hawai'i.Asia Pacific journal of clinical nutritionArticle
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStroke is the second cause of death among elderly people. Oxidative stress plays an important role in brain damage after stroke. Currently, Vitamin D has been shown as an antioxidant. The aim of this study was to evaluate the status of Vitamin D, antioxidant enzymes, and the relation between them in ischemic stroke patients. MATERIALS AND
methodsThis case-control study was carried out on 36 patients with ischemic stroke patients and 36 matched subjects as controls. Intake of fruits and vegetables, exposure of sunlight, serum lipid profile, concentrations of serum 25-dihydroxy Vitamin D (25(OH) D), activities of serum superoxide dismutase, and glutathione peroxidase enzymes were determined.
resultsSevere Vitamin D deficiency was seen in 30% of the patients versus 11% of the controls (P < 0.05). Consumption of fruits and vegetables was lower in patients than that of controls (P < 0.05). Activities of antioxidant enzymes and intake of fruits were positively correlated in stroke patients (P = 0.02). The most potent predictors of stroke risk were hypertension, high levels of low-density lipoprotein cholesterol (LDL-C) and history of cardiovascular disease (CVD) (odds ratios: 3.33, 3.15, and 3.14, respectively, P < 0.05 for all). There was no association between 25(OH) D levels with activities of serum antioxidant enzymes and lipid profile in the two groups.
conclusionIschemic stroke patients have higher prevalence of severe Vitamin D deficiency and lower intakes of fruits and vegetables. Intake of fruits was positive correlated to higher antioxidant enzymes levels. High levels of blood pressure, history of CVD, and high LDL-C levels are the strongest predictors of ischemic stroke.
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