ArticleJournal of pathology informatics2015
Practical considerations in genomic decision support: The eMERGE experience.
Article in Journal of pathology informatics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Delivering genomic medicine in the United Kingdom National Health Service: a systematic review and narrative synthesis.Genetics in medicine : official journal of the American College of Medical Genetics · 2019Pooled it
- Care Team Attributes Predict Likelihood of Utilizing Pharmacogenomic Information During Inpatient Prescribing.Clinical and translational science · 2025Observational
- Barriers and facilitators of the use of clinical informatics resources to facilitate pharmacogenomic implementation in resource-limited settings.JAMIA open · 2024Article
- DNA and RNA Molecules as a Foundation of Therapy Strategies for Treatment of Cardiovascular Diseases.Pharmaceutics · 2023Review
- Pharmacogenomic Clinical Decision Support: A Review, How-to Guide, and Future Vision.Clinical pharmacology and therapeutics · 2022Review
- Clinical implementation of drug metabolizing gene-based therapeutic interventions worldwide.Human genetics · 2022Review
- Article
- Engaging pharmacogenomics in pain management and opioid selection.Pharmacogenomics · 2021Review
- Meeting the challenge: Health information technology's essential role in achieving precision medicine.Journal of the American Medical Informatics Association : JAMIA · 2021Article
- Infobuttons for Genomic Medicine: Requirements and Barriers.Applied clinical informatics · 2021Article
- Pharmacogenomics.Lancet (London, England) · 2019Review
- Review
- Preliminary outcomes of preemptive warfarin pharmacogenetic testing at a large rural healthcare center.American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists · 2019Article
- Pharmacogenomic clinical decision support design and multi-site process outcomes analysis in the eMERGE Network.Journal of the American Medical Informatics Association : JAMIA · 2019Article
- Advances in Sharing Multi-sourced Health Data on Decision Support Science 2016-2017.Yearbook of medical informatics · 2018Review
- Implementing pharmacogenomics decision support across seven European countries: The Ubiquitous Pharmacogenomics (U-PGx) project.Journal of the American Medical Informatics Association : JAMIA · 2018Article
- Standardization can accelerate the adoption of pharmacogenomics: current status and the path forward.Pharmacogenomics · 2018Review
- Views Of Primary Care Providers On Testing Patients For Genetic Risks For Common Chronic Diseases.Health affairs (Project Hope) · 2018Article
- Prospects and challenges for clinical decision support in the era of big data.JCO clinical cancer informatics · 2018Article
- Leveraging the Learning Health Care Model to Improve Equity in the Age of Genomic Medicine.Learning health systems · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
30 authors.
Funding
Abstract
backgroundGenomic medicine has the potential to improve care by tailoring treatments to the individual. There is consensus in the literature that pharmacogenomics (PGx) may be an ideal starting point for real-world implementation, due to the presence of well-characterized drug-gene interactions. Clinical Decision Support (CDS) is an ideal avenue by which to implement PGx at the bedside. Previous literature has established theoretical models for PGx CDS implementation and discussed a number of anticipated real-world challenges. However, work detailing actual PGx CDS implementation experiences has been limited. Anticipated challenges include data storage and management, system integration, physician acceptance, and more.
methodsIn this study, we analyzed the experiences of ten members of the Electronic Medical Records and Genomics (eMERGE) Network, and one affiliate, in their attempts to implement PGx CDS. We examined the resulting PGx CDS system characteristics and conducted a survey to understand the unanticipated implementation challenges sites encountered.
resultsTen sites have successfully implemented at least one PGx CDS rule in the clinical setting. The majority of sites elected to create an Omic Ancillary System (OAS) to manage genetic and genomic data. All sites were able to adapt their existing CDS tools for PGx knowledge. The most common and impactful delays were not PGx-specific issues. Instead, they were general IT implementation problems, with top challenges including team coordination/communication and staffing. The challenges encountered caused a median total delay in system go-live of approximately two months.
conclusionsThese results suggest that barriers to PGx CDS implementations are generally surmountable. Moreover, PGx CDS implementation may not be any more difficult than other healthcare IT projects of similar scope, as the most significant delays encountered were not unique to genomic medicine. These are encouraging results for any institution considering implementing a PGx CDS tool, and for the advancement of genomic medicine.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.