ArticleZoological letters2015
Unexpected link between polyketide synthase and calcium carbonate biomineralization.
Article in Zoological letters, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 32 citations in OpenAlex.
- Development of the semicircular canals and otolithic organs of the vertebrate inner ear.Current topics in developmental biology · 2025Review
- Article
- Gene regulatory divergence amongst echinoderms underlies appearance of pigment cells in sea urchin development.Developmental biology · 2023Article
- Sea Urchin Polyketide Synthase SpPks1 Produces the Naphthalene Precursor to Echinoderm Pigments.Journal of the American Chemical Society · 2022Article
- Integrated omics unveil the secondary metabolic landscape of a basal dinoflagellate.BMC biology · 2020Article
- Association of Phosphatidylinositol-Specific Phospholipase C with Calcium-Induced Biomineralization in the CoccolithophoreMicroorganisms · 2020Article
- Cilia in the developing zebrafish ear.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Linking Genes to Molecules in Eukaryotic Sources: An Endeavor to Expand Our Biosynthetic Repertoire.Molecules (Basel, Switzerland) · 2020Review
- Polyketide Synthase Plays a Conserved Role in Otolith Formation.Zebrafish · 2019Article
- Zebrafish otolith biomineralization requires polyketide synthase.Mechanisms of development · 2019Article
- Screening of Fungi for Potential Application of Self-Healing Concrete.Scientific reports · 2019Article
- Biochemical characterization of the minimal domains of an iterative eukaryotic polyketide synthase.The FEBS journal · 2018Article
- Article
- A hybrid polyketide-nonribosomal peptide in nematodes that promotes larval survival.Nature chemical biology · 2016Article
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionCalcium carbonate biominerals participate in diverse physiological functions. Despite intensive studies, little is known about how mineralization is initiated in organisms.
resultsWe analyzed the medaka spontaneous mutant, ha, defective in otolith (calcareous ear stone) formation. ha lacks a trigger for otolith mineralization, and the causative gene was found to encode polyketide synthase (pks), a multifunctional enzyme mainly found in bacteria, fungi, and plant. Subsequent experiments demonstrate that the products of medaka PKS, most likely polyketides or their derivatives, act as nucleation facilitators in otolith mineralization. The generality of this novel PKS function is supported by the essential role of echinoderm PKS in calcareous skeleton formation together with the presence of PKSs in a much wider range of animals from coral to vertebrates.
conclusionThe present study first links PKS to biomineralization and provides a genetic cue for biogeochemistry of carbon and calcium cycles.
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