ArticleImmunity & ageing : I & A2015
Characteristics of spinal microglia in aged and obese mice: potential contributions to impaired sensory behavior.
Article in Immunity & ageing : I & A, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- Rejuvenation alleviates prolonged postsurgical pain in aging mice by mitigating inflammaging.Pain · 2025Article
- Obesity aggravates the role of C-reactive protein on knee pain: A cross-sectional analysis with NHANES data.Immunity, inflammation and disease · 2024Article
- Underlying Mechanisms and Treatment of Cellular Senescence-Induced Biological Barrier Interruption and Related Diseases.Aging and disease · 2024Review
- Temporal changes of spinal microglia in murine models of neuropathic pain: a scoping review.Frontiers in immunology · 2024Article
- Bioenergetic Impairment in the Neuro-Glia-Vascular Unit: An Emerging Physiopathology during Aging.Aging and disease · 2021Review
- Diet-induced obesity leads to behavioral indicators of pain preceding structural joint damage in wild-type mice.Arthritis research & therapy · 2021Article
- Transcriptomic and functional studies reveal undermined chemotactic and angiostimulatory properties of aged microglia during stroke recovery.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Article
- Diet-induced obesity decreases rate-dependent depression in the Hoffmann's reflex in adult mice.Physiological reports · 2019Article
- Article
- Spinal microglial activation in a murine surgical model of knee osteoarthritis.Osteoarthritis and cartilage · 2017Article
- Dysfunction of the neurovascular unit in ischemic stroke and neurodegenerative diseases: An aging effect.Ageing research reviews · 2017Review
- Cerebral Vascular Disease and Neurovascular Injury in Ischemic Stroke.Circulation research · 2017Review
- Review
- Article
- Spinal Cord Microglia in Health and Disease.Acta naturaeArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBoth aging and obesity have been recognized widely as health conditions that profoundly affect individuals, families and the society. Aged and obese people often report altered pain responses while underlying mechanisms have not been fully elucidated. We aim to understand whether spinal microglia could potentially contribute to altered sensory behavior in aged and obese population.
resultsIn this study, we monitored pain behavior in adult (6 months) and aged (17 months) mice fed with diet containing 10 % or 60 % Kcal fat. The group of young adult (3 months) mice was included as theoretical baseline control. Compared with lean adult animals, diet-induced-obese (DIO) adult, lean and DIO-aged mice showed enhanced painful response to heat and cold stimuli, while exhibiting hyposensitivity to mechanical stimulation. The impact of aging and obesity on microglia properties was evidenced by an increased microglial cell density in the spinal cords, stereotypic morphological changes and polarization towards pro-inflammatory phenotype. Obesity strikingly exacerbated the effect of aging on spinal microglia.
conclusionAging/obesity altered microglia properties in the spinal cords, which can dysregulate neuron-microglia crosstalk and impair physiological pain signal transmission. The inflammatory functions of microglia have special relevance for understanding of abnormal pain behavior in aged/obese populations.
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