Evidence map›Paper›PMID 26604910›Full record

ArticleNeural regeneration research2015

Hyperbaric oxygen therapy combined with Schwann cell transplantation promotes spinal cord injury recovery.

Chuan-Gang Peng, Shu-Quan Zhang, Min-Fei Wu, Yang Lv, Dan-Kai Wu, Qi Yang, Rui Gu

Open access · goldAbstract read
In one paragraph

Article in Neural regeneration research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Chuan-Gang PengDepartment of Orthopedics, China-Japan Union Hospital of Jilin University, Changchun, Jilin Province, China.
Shu-Quan ZhangDepartment of Orthopedics, Tianjin Nankai Hospital, Tianjin, China.
Min-Fei WuDepartment of Orthopedics, China-Japan Union Hospital of Jilin University, Changchun, Jilin Province, China.
Yang LvDepartment of Orthopedics, China-Japan Union Hospital of Jilin University, Changchun, Jilin Province, China.
Dan-Kai WuDepartment of Orthopedics, China-Japan Union Hospital of Jilin University, Changchun, Jilin Province, China.
Qi YangDepartment of Dynaecology and Obstetrics, China-Japan Union Hosptial of Jilin University, Changchun, Jilin Province, China.
Rui GuDepartment of Orthopedics, China-Japan Union Hospital of Jilin University, Changchun, Jilin Province, China.ORCID 0000-0003-4406-1553
Jilin University · CNTianjin Nankai Hospital · CNUnion Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Schwann cell transplantation and hyperbaric oxygen therapy each promote recovery from spinal cord injury, but it remains unclear whether their combination improves therapeutic results more than monotherapy. To investigate this, we used Schwann cell transplantation via the tail vein, hyperbaric oxygen therapy, or their combination, in rat models of spinal cord contusion injury. The combined treatment was more effective in improving hindlimb motor function than either treatment alone; injured spinal tissue showed a greater number of neurite-like structures in the injured spinal tissue, somatosensory and motor evoked potential latencies were notably shorter, and their amplitudes greater, after combination therapy than after monotherapy. These findings indicate that Schwann cell transplantation combined with hyperbaric oxygen therapy is more effective than either treatment alone in promoting the recovery of spinal cord in rats after injury.

Indexed as

central nervous systemelectrophysiologyhyperbaric oxygen therapymotor functionnerve regenerationneural regenerationratsrepairSchwann cellsspinal cord injurytransplantation

Identifiers

PMID26604910
PMCPMC4625515
OpenAlexW1878487335

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.