ReviewNeural regeneration research2015
Enhancing endogenous stem cells in the newborn via delayed umbilical cord clamping.
Review in Neural regeneration research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- Effect of intact cord resuscitation versus conventional cord clamping on clinical outcomes in very preterm neonates: a randomized controlled trial from Eastern India.European journal of pediatrics · 2026Trial
- Umbilical cord milking in nonvigorous infants: a cluster-randomized crossover trial.American journal of obstetrics and gynecology · 2023Trial
- Effect of delayed cord clamping on stem cell transfusion and hematological parameters in preterm infants with placental insufficiency: a pilot randomized trial.European journal of pediatrics · 2021Trial
- How Delayed Cord Clamping Saves Newborn Lives.Children (Basel, Switzerland) · 2025Review
- Effect of Delayed Cord Clamping on Respiratory Infection-Related Encounters in the First 6 Months of Life in an Urban Community Hospital.International journal of pediatrics · 2025Article
- Impact of delayed cord clamping on mesenchymal, hemopoietic progenitor, and immune cells in very preterm neonates.Frontiers in pediatrics · 2025Article
- Effect of different timings of umbilical cord clamping on the level of CD34Scientific reports · 2023Article
- New frontiers in neonatal red blood cell transfusion research.Journal of perinatology : official journal of the California Perinatal Association · 2023Review
- Cord management in non-vigorous newborns.Seminars in perinatology · 2023Article
- Cardiac Asystole at Birth Re-Visited: Effects of Acute Hypovolemic Shock.Children (Basel, Switzerland) · 2023Review
- Protocol for a Nested, Retrospective Study of the Australian Placental Transfusion Study Cohort.Cureus · 2022Article
- What does the evidence tell us? Revisiting optimal cord management at the time of birth.European journal of pediatrics · 2022Review
- Making the Argument for Intact Cord Resuscitation: A Case Report and Discussion.Children (Basel, Switzerland) · 2022Review
- Effects of Umbilical Cord Management Strategies on Stem Cell Transfusion, Delivery Room Adaptation, and Cerebral Oxygenation in Term and Late Preterm Infants.Frontiers in pediatrics · 2022Article
- Early versus delayed umbilical cord clamping on maternal and neonatal outcomes.Archives of gynecology and obstetrics · 2019Review
- Umbilical cord milking at birth for term newborns with acidosis: neonatal outcomes.Journal of perinatology : official journal of the California Perinatal Association · 2018Article
- Safety of Autologous Cord Blood Cells for Preterms: A Descriptive Study.Stem cells international · 2018Article
- From cord to caudate: characterizing umbilical cord blood stem cells and their paracrine interactions with the injured brain.Pediatric research · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
There is currently no consensus among clinicians and scientists over the appropriate or optimal timing for umbilical cord clamping. However, many clinical studies have suggested that delayed cord clamping is associated with various neonatal benefits including increased blood volume, reduced need for blood transfusion, increased cerebral oxygenation in pre-term infants, and decreased frequency of iron deficiency anemia in term infants. Human umbilical cord blood contains significant amounts of stem and progenitor cells and is currently used in the treatment of several life-threatening diseases. We propose that delayed cord clamping be encouraged as it enhances blood flow from the placenta to the neonate, which is accompanied by an increase supply of valuable stem and progenitor cells, as well as may improve blood oxygenation and increase blood volume, altogether reducing the infant's susceptibility to both neonatal and age-related diseases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.