Evidence map›Paper›PMID 26604864›Full record

ArticleThe Yale journal of biology and medicine2015

PART of the WHOLE: A Case Study in Wellness-Oriented Personalized Medicine.

Greg Gibson, Urko M Marigorta, Elohor R Ojagbeghru, Subin Park

Abstract readCase Reports
PubMed Full text at PMC
In one paragraph

Article in The Yale journal of biology and medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Greg GibsonSchool of Biology, Center for Integrative Genomics, Georgia Institute of Technology, Atlanta, Georgia.
Urko M MarigortaSchool of Biology, Center for Integrative Genomics, Georgia Institute of Technology, Atlanta, Georgia.
Elohor R OjagbeghruSchool of Biology, Center for Integrative Genomics, Georgia Institute of Technology, Atlanta, Georgia.
Subin ParkSchool of Biology, Center for Integrative Genomics, Georgia Institute of Technology, Atlanta, Georgia.

Funding

Statistical Methods for X-Chromosome Genetic DataP01GM099568 · NIGMS · UNIVERSITY OF WASHINGTON · PI WEIR, BRUCE S. · 2012 to 2016
$7.3M
NIGMS NIH HHS P01 GM099568
6 · The paper itself

Abstract

We describe the Wellness and Health Omics Linked to the Environment (WHOLE) personalized medicine profile for a 50-year-old Caucasian male living in Atlanta, Georgia. Based on the principle that genomic medicine will be most effective when presented in the context of an individual's clinical and lifestyle data, we propose the use of a "risk radar" that summarizes health risks in eight domains. Rather than providing overwhelming lists of potentially deleterious genetic variants, we argue that profiles should be palatable, actionable, reproducible, and teachable: the PART principle. Genetic risk scores for this individual are strikingly concordant for his height, body mass index (BMI), waist hip ration (WHR), and cholesterol, and blood transcriptome data agrees with and complements his complete blood counts. Despite enjoying currently good health, his risk radar highlights metabolic disease as his major health concern.

Indexed as

Gene Expression ProfilingGenetic Predisposition to DiseaseHealth PromotionHumansMaleMiddle AgedPrecision MedicineRisk AssessmentRisk Reduction Behaviorgenetic risk scorepersonalized medicinetranscriptome profilewellness

Identifiers

PMID26604864
PMCPMC4654189

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.