Evidence map›Paper›PMID 26604824›Full record

ReviewClinical epidemiology2015

The Danish National Patient Registry: a review of content, data quality, and research potential.

Morten Schmidt, Sigrun Alba Johannesdottir Schmidt, Jakob Lynge Sandegaard, Vera Ehrenstein, Lars Pedersen, Henrik Toft Sørensen

Registry-linked trialAbstract readReview
In one paragraph

Review in Clinical epidemiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03142139 (Timing of Vaccination With the Non-live DTaP-IPV-Hib Vaccine and Development of Atopic Dermatitis Before 1 Year of Age - a Danish Register Based Cohort Study), which is not on this map. Cited by 2,286 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2,286citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03142139 completednot on this map

Timing of Vaccination With the Non-live DTaP-IPV-Hib Vaccine and Development of Atopic Dermatitis Before 1 Year of Age - a Danish Register Based Cohort Study

TypeobservationalSponsorBandim Health ProjectRan1997 to 2014Enrolled1,027,559ConditionsAtopic DermatitisArmsRQ1a: Delayed vs. timely vaccination with the 1st dose of DTaP-IPV-Hib, RQ1b: Delayed vs. timely vaccination with the 2nd dose of DTaP-IPV-Hib, RQ2: Vaccination with DTaP-IPV-Hib compared to being unvaccinated
3 · Its place in the literature

Who cites it

2,286 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Machine Learning Based Diagnostic Models for Hip and Knee Prosthetic Joint Infection: A Systematic Review.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026
    Pooled it
  3. Trial
  4. Relative effectiveness of high-dose versus standard-dose influenza vaccine against hospitalizations and mortality according to Charlson Comorbidity Index: A post-hoc analysis of the DANFLU-1 randomized trial.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Trial
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  8. Observational
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  14. Denosumab-efficacy, safety, persistence and sequential strategies-a systematic review.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026
    Review
  15. Incidence and Mortality of Community-Acquired Sepsis or Bacteraemia in Patients With Alcohol-Related Cirrhosis.Liver international : official journal of the International Association for the Study of the Liver · 2026
    Article
  16. Article
  17. Long-term incidence of infective endocarditis according to the type of cardiac implantable electronic device: a nationwide comparison with moderate- and high-risk patient groups.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
    Article
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2,226 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Morten SchmidtDepartment of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.
Sigrun Alba Johannesdottir SchmidtDepartment of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.
Jakob Lynge SandegaardDepartment of Health Documentation, State Serum Institute, Copenhagen, Denmark.
Vera EhrensteinDepartment of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.
Lars PedersenDepartment of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.
Henrik Toft SørensenDepartment of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe Danish National Patient Registry (DNPR) is one of the world's oldest nationwide hospital registries and is used extensively for research. Many studies have validated algorithms for identifying health events in the DNPR, but the reports are fragmented and no overview exists.

objectivesTo review the content, data quality, and research potential of the DNPR.

methodsWe examined the setting, history, aims, content, and classification systems of the DNPR. We searched PubMed and the Danish Medical Journal to create a bibliography of validation studies. We included also studies that were referenced in retrieved papers or known to us beforehand. Methodological considerations related to DNPR data were reviewed.

resultsDuring 1977-2012, the DNPR registered 8,085,603 persons, accounting for 7,268,857 inpatient, 5,953,405 outpatient, and 5,097,300 emergency department contacts. The DNPR provides nationwide longitudinal registration of detailed administrative and clinical data. It has recorded information on all patients discharged from Danish nonpsychiatric hospitals since 1977 and on psychiatric inpatients and emergency department and outpatient specialty clinic contacts since 1995. For each patient contact, one primary and optional secondary diagnoses are recorded according to the International Classification of Diseases. The DNPR provides a data source to identify diseases, examinations, certain in-hospital medical treatments, and surgical procedures. Long-term temporal trends in hospitalization and treatment rates can be studied. The positive predictive values of diseases and treatments vary widely (<15%-100%). The DNPR data are linkable at the patient level with data from other Danish administrative registries, clinical registries, randomized controlled trials, population surveys, and epidemiologic field studies - enabling researchers to reconstruct individual life and health trajectories for an entire population.

conclusionThe DNPR is a valuable tool for epidemiological research. However, both its strengths and limitations must be considered when interpreting research results, and continuous validation of its clinical data is essential.

Indexed as

epidemiological methodsmedical record linkageregistriesresearch designvalidation studies

Identifiers

PMID26604824
PMCPMC4655913

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.