ArticleInternational journal of nanomedicine2015
Role of surface charge in determining the biological effects of CdSe/ZnS quantum dots.
Article in International journal of nanomedicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Reusable Turn-on Fluorescent Biosensor for Cardiac Biomarker Troponin I Detection Using QDs-SPION-Aptamer.Journal of fluorescence · 2025Article
- Elementary Charge Characterization of Single Quantum Dots in Solution.Nano letters · 2025Article
- Versatile Prepolymer Platform for Controlled Tailoring of Quantum Dot Surface Properties.ACS applied materials & interfaces · 2024Article
- Cellular uptake, intracellular behavior, and acute/sub-acute cytotoxicity of a PEG-modified quantum dot with promisingHeliyon · 2023Article
- Nanodrugs with intrinsic radioprotective exertion: Turning the double-edged sword into a single-edged knife.Exploration (Beijing, China) · 2023Review
- Dependence of Quantum Dot Toxicity In Vitro on Their Size, Chemical Composition, and Surface Charge.Nanomaterials (Basel, Switzerland) · 2022Article
- Impact of Tuning the Surface Charge Distribution on Colloidal Iron Oxide Nanoparticle Toxicity Investigated inNanomaterials (Basel, Switzerland) · 2021Article
- Transcriptome Profile Alterations with Carbon Nanotubes, Quantum Dots, and Silver Nanoparticles: A Review.Genes · 2021Review
- Density of surface charge is a more predictive factor of the toxicity of cationic carbon nanoparticles than zeta potential.Journal of nanobiotechnology · 2021Article
- The Effects of Gold Nanoparticles on Leydig Cells and Male Reproductive Function in Mice.International journal of nanomedicine · 2020Article
- Transcriptome Profile Alteration with Cadmium Selenide/Zinc Sulfide Quantum Dots inBiomolecules · 2019Article
- Quantum dot therapeutics: a new class of radical therapies.Journal of biological engineering · 2019Review
- Anti-ICAM-1 antibody-modified nanostructured lipid carriers: a pulmonary vascular endothelium-targeted device for acute lung injury therapy.Journal of nanobiotechnology · 2018Article
- Expression and significance of quantum dots in RAW 264.7 macrophages.Oncology letters · 2018Article
- SiOScientific reports · 2018Article
- Nanoparticle delivery to metastatic breast cancer cells by nanoengineered mesenchymal stem cells.Beilstein journal of nanotechnology · 2018Article
- Effects of arginine-glycine-aspartic acid peptide-conjugated quantum dots-induced photodynamic therapy on pancreatic carcinoma in vivo.International journal of nanomedicine · 2017Article
- Inner ear barriers to nanomedicine-augmented drug delivery and imaging.Journal of otology · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The growing potential of quantum dots (QDs) in biomedical applications has provoked the urgent need to thoroughly address their interaction with biological systems. However, only limited studies have been performed to explore the effects of surface charge on the biological behaviors of QDs. In the present study, three commercially available QDs with different surface coatings were used to systematically evaluate the effects of surface charge on the cellular uptake, cytotoxicity, and in vivo biodistribution of QDs. Our results demonstrated that charged QDs entered both cancer cells and macrophages more efficiently than neutral ones, while negative QDs internalized mostly. Upon entry into cells, QDs were localized in different subcellular compartments (eg, cytoplasm and lysosomes) depending on the surface charge. Interestingly, inconsistent with the result of internalization, positive QDs but not negative QDs exhibited severe cytotoxicity, which was likely due to their disruption of cell membrane integrity, and production of reactive oxygen species. Biodistribution studies demonstrated that negative and neutral QDs preferentially distributed in the liver and the spleen, whereas positive QDs mainly deposited in the kidney with obvious uptake in the brain. In general, surface charge plays crucial roles in determining the biological interactions of QDs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.