Evidence map›Paper›PMID 26604746›Full record

ArticleInternational journal of nanomedicine2015

Biodegradable mesoporous calcium-magnesium silicate-polybutylene succinate scaffolds for osseous tissue engineering.

Xinxin Zhang, Chi Zhang, Wei Xu, Biao Zhong, Feng Lin, Jian Zhang, Quanxiang Wang, Jiajin Ji, Jie Wei, Yang Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of nanomedicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Osteogenesis-synchronized degradation of MgBiomedical engineering online · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xinxin ZhangTongRen Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China ; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
Chi ZhangShanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
Wei XuTongRen Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
Biao ZhongShanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
Feng LinShanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
Jian ZhangShanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
Quanxiang WangKey Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai, People's Republic of China.
Jiajin JiKey Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai, People's Republic of China.
Jie WeiKey Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai, People's Republic of China.
Yang ZhangTongRen Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The structural features of bone engineering scaffolds are expected to exhibit osteoinductive behavior and promote cell adhesion, proliferation, and differentiation. In the present study, we employed synthesized ordered mesoporous calcium-magnesium silicate (om-CMS) and polybutylene succinate (PBSu) to develop a novel scaffold with potential applications in osseous tissue engineering. The characteristics, in vitro bioactivity of om-CMS/PBSu scaffold, as well as the cellular responses of MC3T3-E1 cells to the composite were investigated. Our results showed that the om-CMS/PBSu scaffold possesses a large surface area and highly ordered channel pores, resulting in improved degradation and biocompatibility compared to the PBSu scaffold. Moreover, the om-CMS/PBSu scaffold exhibited significantly higher bioactivity and induced apatite formation on its surface after immersion in the simulated body fluid. In addition, the om-CMS/PBSu scaffold provided a high surface area for cell attachment and released Ca, Mg, and Si ions to stimulate osteoblast proliferation. The unique surface characteristics and higher biological efficacy of the om-CMS/PBSu scaffold suggest that it has great potential for being developed into a system that can be employed in osseous tissue engineering.

Indexed as

AnimalsAsbestos, AmphiboleBone and BonesButylene GlycolsCell AdhesionCell LineCell ProliferationHydrogen-Ion ConcentrationMiceMolecular WeightNitrogenPolymersPorositySpectroscopy, Fourier Transform InfraredTemperatureTissue EngineeringAsbestos, AmphibolebionoleButylene GlycolsNitrogenPolymerstremolitebone repaircalcium–magnesium silicateordered mesoporouspolybutylene succinateproliferation

Identifiers

PMID26604746
PMCPMC4630181

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.