ArticleDrug design, development and therapy2015
Phytocompounds and modulatory effects of Anacardium microcarpum (cajui) on antibiotic drugs used in clinical infections.
Article in Drug design, development and therapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Antioxidant and Antimicrobial Activities of Crude Extracts and Fractions of Cashew (Oxidative medicine and cellular longevity · 2018Pooled it
- Unveiling the Dual Mechanisms ofInternational journal of molecular sciences · 2026Article
- Fractionation, identification of chemical constituents, and biological properties of cashew (Food science & nutrition · 2023Article
- Micromorphology and Chemical Studies onPlants (Basel, Switzerland) · 2022Article
- Article
- Anacardium excelsum phytochemical analysis and in vitro antimicrobial activity against oral cavity microorganisms.Acta odontologica latinoamericana : AOL · 2021Article
- Biomedical Properties of Propolis on Diverse Chronic Diseases and Its Potential Applications and Health Benefits.Nutrients · 2020Review
- Antimicrobial effect of anacardic acid-loaded zein nanoparticles loaded on Streptococcus mutans biofilms.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2020Article
- Antioxidant, Antimicrobial, and Anticancer Effects ofFrontiers in endocrinology · 2020Review
- Seasonal Variation in Essential Oils Composition and the Biological and Pharmaceutical Protective Effects ofBioMed research international · 2018Article
- Article
- Anacardium microcarpum extract and fractions protect against paraquat-induced toxicity in Drosophila melanogaster.EXCLI journal · 2017Article
- Antimicrobial Activity and Modulatory Effect of Essential Oil from the Leaf of Rhaphiodon echinus (Nees & Mart) Schauer on Some Antimicrobial Drugs.Molecules (Basel, Switzerland) · 2016Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe challenge of antibiotic resistance and the emergence of new infections have generated considerable interest in the exploration of natural products from plant origins as combination therapy. In this context, crude ethanolic extract (CEE), ethyl acetate fraction (EAF), and methanolic fraction (MF) from Anacardium microcarpum were tested alone or in combination with antibiotics (amikacin, gentamicin, ciprofloxacin, and imipenem) against Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus.
methodsAntibiotic resistance-modifying activity was performed using the microdilution method by determining the minimal inhibitory concentration (MIC). In addition, phytochemical prospecting analyses of tested samples were carried out.
resultsOur results indicated that all the extracts showed low antibacterial activity against multidrug-resistant strains (MIC =512 μg/mL). However, addition of CEE, EAF, and MF to the growth medium at the subinhibitory concentration (MIC/8=64 μg/mL) significantly modulated amikacin- and gentamicin-resistant E. coli 06. CEE and EAF also demonstrated a significant (P<0.001) synergism with imipenem against S. aureus. In contrast, MF antagonized the antibacterial effect of ciprofloxacin and gentamicin against P. aeruginosa 03 and S. aureus 10, respectively. Qualitative phytochemical analysis of the extracts revealed the presence of secondary metabolites including phenols, flavonoids, xanthones, chalcones, and tannin pyrogallates.
conclusionTaken together, our results suggest that A. microcarpum is a natural resource with resistance-modifying antibacterial activity that needs to be further investigated to overcome the present resistant-infection problem.
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