Evidence map›Paper›PMID 26604685›Full record

ArticleDrug design, development and therapy2015

Prevalence of the rs7903146C>T polymorphism in TCF7L2 gene for prediction of type 2 diabetes risk among Iranians of different ethnicities.

Mojgan Allahdini, Behnam Kamalidehghan, Leila Akbari, Parisa Azadfar, Ali Rahmani, Fatemeh Ahmadipour, Goh Yong Meng, Abbas Masserrat, Massoud Houshmand

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug design, development and therapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Mojgan AllahdiniDepartment of Molecular Biology, Ahar Branch Islamic Azad University, Ahar, Iran.
Behnam KamalidehghanPharmacy Department, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Leila AkbariDepartment of Biology, Sciences and Research Branch, Azad University, Tehran, Iran.
Parisa AzadfarDepartment of Biology, Sciences and Research Branch, Azad University, Tehran, Iran.
Ali RahmaniDepartment of Molecular Biology, Ahar Branch Islamic Azad University, Ahar, Iran.
Fatemeh AhmadipourPharmacy Department, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Goh Yong MengDepartment of Veterinary Preclinical Sciences, Faculty of Veterinary Medicine, Universiti Putra Malaysia, Serdang, Malaysia.
Abbas MasserratDepartment of Medical Genetics, Taban Clinic, Tehran, Iran.
Massoud HoushmandDepartment of Medical Genetics, National Institute of Genetic Engineering and Biotechnology (NIGEB), Tehran, Iran.
Islamic Azad University of Ahar · IRUniversity of Malaya · MYNational Institute of Genetic Engineering and Biotechnology · IRUniversiti Putra Malaysia · MY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPharmacogenetics is the study of genetic polymorphisms affecting responses to drug therapy. The common rs7903146 (C>T) polymorphism of the TCF7L2 gene has recently been associated with type 2 diabetes (T2D). In this study, prevalence of the rs7903146 (C>T) polymorphism in the TCF7L2 gene for prediction of T2D risk was examined in an Iranian population of different ethnicities.

methodsThe prevalence of rs7903146 (C>T) and the predicted phenotypes, including extensive metabolizers, intermediate metabolizers, and poor metabolizers were investigated in blood samples of 300 unrelated healthy individuals in an Iranian population, including Fars, Turk, Lure, and Kurd, using polymerase chain reaction restriction fragment length polymorphism and direct genomic DNA sequencing.

resultsThe homozygous wild-type (C/C), heterozygous (C/T), and homozygous (T/T) allelic frequencies of rs7903146 (C>T) in the TCF7L2 gene were 29% (extensive metabolizers), 66.34% (intermediate metabolizers), and 4.66% (poor metabolizers), respectively. The C/C, C/T, and T/T genotypic frequencies of the rs7903146 (C>T) allele were significantly different (P<0.01) among Iranians of different ethnicities. The frequency of the homozygous T/T variant of the rs7903146 (C>T) allele was significantly low in the Lure (P<0.01) and high in the Fars (P<0.001) ethnicities. Additionally, the frequency of the T/T variant of the rs7903146 (C>T) allele in the South of Iran was the highest (P<0.04), while the East of Iran had the lowest frequency (P<0.01).

conclusionThe prediction of rs7903146 (C>T) is required in drug research and routine treatment, where the information would be helpful for clinicians to optimize therapy and adverse drug reactions and predict drug response in individuals at risk of T2D.

Indexed as

Genetic Predisposition to DiseaseAllelesDiabetes Mellitus, Type 2HumansIranPharmacogeneticsPolymerase Chain ReactionPolymorphism, Restriction Fragment LengthPolymorphism, Single NucleotidePrevalenceRiskSequence Analysis, DNATranscription Factor 7-Like 2 ProteinTCF7L2 protein, humanTranscription Factor 7-Like 2 ProteinFars Turk Lure and KurdIranian populations of different ethnicitiespharmacogenetics of type 2 diabetes (T2D)rs7903146 (C>T) SNPTCF7L2transcription factor 7-like 2 gene

Identifiers

PMID26604685
PMCPMC4629960
OpenAlexW1824423679

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