ArticleMolecular vision2015
Transcriptome networks in the mouse retina: An exon level BXD RI database.
Article in Molecular vision, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
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- Hippocampal Transcriptome-Wide Association Study Reveals Correlations Between Impaired Glutamatergic Synapse Pathway and Age-Related Hearing Loss in BXD-Recombinant Inbred Mice.Frontiers in neuroscience · 2021Article
- Inducible rodent models of glaucoma.Progress in retinal and eye research · 2020Review
- A systems genetics approach to revealing theMolecular vision · 2020Article
- Using BXD mouse strains in vision research: A systems genetics approach.Molecular vision · 2020Review
- Investigating a downstream gene ofMolecular vision · 2019Article
- RNA sequencing profiling of the retina in C57BL/6J and DBA/2J mice: Enhancing the retinal microarray data sets from GeneNetwork.Molecular vision · 2019Article
- Genomic Locus Modulating IOP in the BXD RI Mouse Strains.G3 (Bethesda, Md.) · 2018Article
- Genomic loci modulating retinal ganglion cell death following elevated IOP in the mouse.Experimental eye research · 2018Article
- Express: A database of transcriptome profiles encompassing known and novel transcripts across multiple development stages in eye tissues.Experimental eye research · 2018Article
- Genomic locus modulating corneal thickness in the mouse identifies POU6F2 as a potential risk of developing glaucoma.PLoS genetics · 2018Article
- The genetic dissection ofMolecular vision · 2018Article
- Optic nerve regeneration in the mouse is a complex trait modulated by genetic background.Molecular vision · 2018Article
- Transcriptional Changes in the Mouse Retina after Ocular Blast Injury: A Role for the Immune System.Journal of neurotrauma · 2018Article
- Dissection of Z-disc myopalladin gene network involved in the development of restrictive cardiomyopathy using system genetics approach.World journal of cardiology · 2017Article
- Genetic Networks in Mouse Retinal Ganglion Cells.Frontiers in genetics · 2016Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
purposeDifferences in gene expression provide diverse retina phenotypes and may also contribute to susceptibility to injury and disease. The present study defines the transcriptome of the retina in the BXD RI strain set, using the Affymetrix Mouse Gene 2.0 ST array to investigate all exons of traditional protein coding genes, non-coding RNAs, and microRNAs. These data are presented in a highly interactive database on the GeneNetwork website.
methodsIn the Normal Retina Database, the mRNA levels of the transcriptome from retinas was quantified using the Affymetrix Mouse Gene 2.0 ST array. This database consists of data from male and female mice. The data set includes a total of 52 BXD RI strains, the parental strains (C57BL/6J and DBA/2J), and a reciprocal cross.
resultsIn combination with GeneNetwork, the Department of Defense (DoD) Congressionally Directed Medical Research Programs (CDMRP) Normal Retina Database provides a large resource for mapping, graphing, analyzing, and testing complex genetic networks. Protein-coding and non-coding RNAs can be used to map quantitative trait loci (QTLs) that contribute to expression differences among the BXD strains and to establish links between classical ocular phenotypes associated with differences in the genomic sequence. Using this resource, we extracted transcriptome signatures for retinal cells and defined genetic networks associated with the maintenance of the normal retina. Furthermore, we examined differentially expressed exons within a single gene.
conclusionsThe high level of variation in mRNA levels found among the BXD RI strains makes it possible to identify expression networks that underline differences in retina structure and function. Ultimately, we will use this database to define changes that occur following blast injury to the retina.
Indexed as
Identifiers
26604663PMC4626778W2257300821What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.