ReviewJournal of maxillofacial and oral surgery2015
Osteoradionecrosis of the Jaws: Clinico-Therapeutic Management: A Literature Review and Update.
Review in Journal of maxillofacial and oral surgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
53 citing papers in PubMed, 4 syntheses or guidelines pooled it, 113 citations in OpenAlex.
- Identifying risk factors for osteoradionecrosis of the jaws: a systematic review and meta-analysis.Clinical oral investigations · 2026Pooled it
- Management of Calvarial Osteoradionecrosis After Treatment of Cutaneous Malignancy: A Systematic Review.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2025Pooled it
- Autologous platelet concentrates in extraction sockets for the prevention of osteoradionecrosis: a systematic review of controlled clinical trials.Oral and maxillofacial surgery · 2022Pooled it
- Survival of dental implants and occurrence of osteoradionecrosis in irradiated head and neck cancer patients: a systematic review and meta-analysis.Clinical oral investigations · 2021Pooled it
- Leukocyte- and platelet-rich fibrin does not provide any additional benefit for tooth extraction in head and neck cancer patients post-radiotherapy: a randomized clinical trial.Medicina oral, patologia oral y cirugia bucal · 2020Trial
- Incidence and Site-Specific Risk Factors of Jaw Osteoradionecrosis for Head and Neck Patients in the IMRT/VMAT Era: Evidence From a Large, Hospital-Based Cohort.Head & neck · 2026Article
- Osteoradionecrosis After Modern Radiotherapy for Oral Cavity Cancer: Incidence and Risk Factors.Laryngoscope investigative otolaryngology · 2026Article
- Exploring lived experiences in oral cavity cancer: an Asia-Pacific perspective on psychosocial challenges and opportunities for enhanced patient-centric care.Journal of cancer survivorship : research and practice · 2026Article
- Risk factors and treatment outcomes in osteoradionecrosis in head and neck cancer patients: a retrospective analysis.Journal of the Korean Association of Oral and Maxillofacial Surgeons · 2025Article
- Prevention of osteoradionecrosis in patients with head and neck cancer treated with radiation therapy.Head & neck · 2025Article
- A review of interaction of radiotherapy and implants in head and neck cancer - implications and strategies to improve outcomes.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2025Review
- Proactive Customized Protocol for Oral Management in Head and Neck Cancer Patients Planned for Radiotherapy.Journal of maxillofacial and oral surgery · 2024Article
- Navigating the Complexities of Radiation Injuries: Therapeutic Principles and Reconstructive Strategies.Journal of personalized medicine · 2024Review
- Transformable self-delivered supramolecular nanomaterials combined with anti-PD-1 antibodies alleviate tumor immunosuppression to treat breast cancer with bone metastasis.Journal of nanobiotechnology · 2024Article
- Pre- and Post-Operative Quality of Life in Patients with Osteoradionecrosis of the Jaw.Cancers · 2024Article
- Therapeutic potential of carbon dots fromAnnals of translational medicine · 2024Article
- Non-odontogenic maxillofacial infections - a 17-years retrospective cohort study.Oral and maxillofacial surgery · 2024Article
- Resemblances and differences between osteoradionecrosis of the jaw and medication-related osteonecrosis of the jaw.Medicine and pharmacy reports · 2024Article
- Oral Surgery and Osteoradionecrosis in Patients Undergoing Head and Neck Radiation Therapy: An Update of the Current Literature.Biomedicines · 2023Review
- Comment on: Predictive value of health-related quality of life on radiotherapy-related toxicities in patients with head and neck cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteoradionecrosis is one of the most serious oral complications of head and neck cancer treatment. It is a severe delayed radiation-induced injury, characterized by bone tissue necrosis and failure to heal for at least 3 months. In most cases osteoradionecrosis gradually progresses, becoming more extensive and painful that leads to infection and pathological fracture. The present paper provides a literature review and update on the risk factors underlying osteoradionecrosis, its clinical and diagnostic particulars, prevention and most widely accepted treatment options including the latest treatment modalities. Lastly, a new early management protocol is proposed based on the current clinical criteria relating to osteonecrosis secondary to treatment with bisphosphonates, together with the adoption of new therapies supported by increased levels of evidence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.