Evidence map›Paper›PMID 26604275›Full record

ArticleDiabetes care2015

Philip E. Cryer, MD: Seminal Contributions to the Understanding of Hypoglycemia and Glucose Counterregulation and the Discovery of HAAF (Cryer Syndrome).

Samuel Dagogo-Jack

Abstract readBiographyHistorical ArticlePortrait
In one paragraph

Article in Diabetes care, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Severe Hypoglycemia and Incident Heart Failure Among Adults With Type 2 Diabetes.The Journal of clinical endocrinology and metabolism · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Samuel Dagogo-JackDivision of Endocrinology, Diabetes and Metabolism, The University of Tennessee Health Science Center, Memphis, TN sdj@uthsc.edu.

Funding

Post-DPP Followup StudiesU01DK048411 · NIDDK · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI DAGOGO-JACK, M.D., D.SC., SAMUEL · 1994 to 2022
$9.2M
Pathobiology of Prediabetes in A Bi-Racial CohortR01DK067269 · NIDDK · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI DAGOGO-JACK, M.D., D.SC., SAMUEL · 2006 to 2017
$6.1M
EDIC: EPIDEMIOLOGY OF DIABETES AND INTERVENTION AND COMPLICATIONS DCC-267962203N01DK062203 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · 1996 to 2004
$2.7M
NIDDK NIH HHS DK48411NIDDK NIH HHS DK62203NIDDK NIH HHS R01 DK067269NIDDK NIH HHS U01 DK048411
6 · The paper itself

Abstract

Optimized glycemic control prevents and slows the progression of long-term complications in patients with type 1 and type 2 diabetes. In healthy individuals, a decrease in plasma glucose below the physiological range triggers defensive counterregulatory responses that restore euglycemia. Many individuals with diabetes harbor defects in their defenses against hypoglycemia, making iatrogenic hypoglycemia the Achilles heel of glycemic control. This Profile in Progress focuses on the seminal contributions of Philip E. Cryer, MD, to our understanding of hypoglycemia and glucose counterregulation, particularly his discovery of the syndrome of hypoglycemia-associated autonomic failure (HAAF).

Indexed as

Autonomic Nervous System DiseasesBlood GlucoseDiabetes ComplicationsEndocrinologyHistory, 20th CenturyHumansHypoglycemiaSyndromeUnited StatesBlood Glucose

Identifiers

PMID26604275
PMCPMC4876742

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.