Evidence map›Paper›PMID 26604143›Full record

SynthesisHuman molecular genetics2016

Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index.

Janine F Felix, Jonathan P Bradfield, Claire Monnereau, Ralf J P van der Valk, Evie Stergiakouli, Alessandra Chesi, Romy Gaillard, Bjarke Feenstra, Elisabeth Thiering, Eskil Kreiner-Møller and 105 more

Registry-linked trialAbstract readMeta-AnalysisMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Human molecular genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01605123 (Leipzig Artherobesity Childhood Cohort), which is not on this map. Cited by 175 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
175citing papers in PubMed, 12 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01605123 completednot on this map

Leipzig Artherobesity Childhood Cohort

TypeobservationalSponsorUniversity of LeipzigRan2007 to 2017Enrolled200ConditionsObesity
3 · Its place in the literature

Who cites it

175 citing papers in PubMed, 12 syntheses or guidelines pooled it.

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  14. Article
  15. Article
  16. Review
  17. Management of Childhood Obesity.International journal of molecular sciences · 2026
    Review
  18. Article
  19. Review
  20. Genetics of Common Obesity in Children and Adolescents.Annals of the New York Academy of Sciences · 2025
    Review

115 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

115 authors.

Janine F FelixThe Generation R Study Group, Department of Pediatrics, Department of Epidemiology, j.felix@erasmusmc.nl.
Jonathan P BradfieldCenter for Applied Genomics.
Claire MonnereauThe Generation R Study Group, Department of Pediatrics, Department of Epidemiology.
Ralf J P van der ValkDepartment of Pulmonology, GRIAC (Groningen Research Institute for Asthma and COPD).
Evie StergiakouliMRC Integrative Epidemiology Unit at the University of Bristol.
Alessandra ChesiDivision of Human Genetics.
Romy GaillardThe Generation R Study Group, Department of Pediatrics, Department of Epidemiology.
Bjarke FeenstraDepartment of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
Elisabeth ThieringInstitute of Epidemiology I, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany, Division of Metabolic and Nutritional Medicine, Dr von Hauner Children's Hospital, University of Munich Medical Center, Munich, Germany.
Eskil Kreiner-MøllerCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital.
Anubha MahajanWellcome Trust Centre for Human Genetics.
Niina PitkänenResearch Centre of Applied and Preventive Cardiovascular Medicine, Institute of Clinical Medicine, Neurology.
Raimo JoroInstitute of Biomedicine, Physiology, University of Eastern Finland, Kuopio, Finland.
Alana CavadinoCentre for Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, UK, Population, Policy and Practice, UCL Institute of Child Health.
Ville HuikariCentre for Life Course Epidemiology.
Steve FranksInstitute of Reproductive and Developmental Biology.
Maria M Groen-BlokhuisDepartment of Biological Psychology, VU University Amsterdam, NCA Neuroscience Campus Amsterdam, EMGO+ Institute for Health and Care Research, Amsterdam, the Netherlands.
Diana L CousminerInstitute for Molecular Medicine, Finland (FIMM), University of Helsinki, Helsinki, Finland.
Julie A MarshSchool of Women's and Infants' Health, The University of Western Australia, Perth, Australia.
Terho LehtimäkiDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland, Department of Clinical Chemistry.
John A CurtinCentre for Respiratory Medicine and Allergy, Institute of Inflammation and Repair, University of Manchester and University Hospital of South Manchester, Manchester Academic Health Sciences Centre, Manchester, UK.
Jesus VioqueUniversidad Miguel Hernandez, Elche-Alicante, Spain, CIBER Epidemiología y Salud Pública (CIBERESP), Spain.
Tarunveer S AhluwaliaCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, Novo Nordisk Foundation Centre for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark, Steno Diabetes Center, Gentofte, Denmark.
Ronny MyhreDepartment of Genes and Envrionment, Division of Epidemiology.
Thomas S PriceDepartment of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, USA.
Natalia Vilor-TejedorCIBER Epidemiología y Salud Pública (CIBERESP), Spain, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain, Pompeu Fabra University (UPF), Barcelona, Spain.
Loïc YengoCNRS UMR8199, Pasteur Institute Lille, France, European Genomic Institute for Diabetes (EGID), Lille, France.
Niels GrarupNovo Nordisk Foundation Centre for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Ioanna NtallaDepartment of Health Sciences, University of Leicester, Leicester, UK, Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece.
Wei AngSchool of Women's and Infants' Health, The University of Western Australia, Perth, Australia.
Mustafa AtalayInstitute of Biomedicine, Physiology, University of Eastern Finland, Kuopio, Finland.
Hans BisgaardCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital.
Alexandra I BlakemoreSection of Investigative Medicine, Division of Diabetes, Endocrinology, and Metabolism, Faculty of Medicine, Imperial College, London, UK.
Amelie BonnefondCNRS UMR8199, Pasteur Institute Lille, France, European Genomic Institute for Diabetes (EGID), Lille, France.
Lisbeth CarstensenDepartment of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
Bone Mineral Density in Childhood Study (BMDCS)
Early Genetics and Lifecourse Epidemiology (EAGLE) consortium
Johan ErikssonNational Institute for Health and Welfare, Helsinki, Finland.
Claudia FlexederInstitute of Epidemiology I, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Lude FrankeDepartment of Genetics.
Frank GellerDepartment of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
Mandy GeserickCenter of Pediatric Research, Department of Women's and Child Health, LIFE Child (Leipzig Research Center for Civilization Diseases).
Anna-Liisa HartikainenInstitute of Clinical Medicine/Obstetrics and Gynecology.
Claire M A HaworthDepartment of Psychology, University of Warwick, UK.
Joel N HirschhornDivision of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, USA, Medical and Population Genetics Program, Broad Institute of MIT and Harvard, Cambridge, USA, Department of Genetics, Harvard Medical School, Boston, USA.
Albert HofmanThe Generation R Study Group, Department of Epidemiology.
Jens-Christian HolmThe Children's Obesity Clinic, Department of Pediatrics, Copenhagen University Hospital Holbæk, The Danish Childhood Obesity Biobank, Denmark, Institute of Medicine, Copenhagen University, Copenhagen, Denmark.
Momoko HorikoshiWellcome Trust Centre for Human Genetics, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.
Jouke Jan HottengaDepartment of Biological Psychology, VU University Amsterdam, NCA Neuroscience Campus Amsterdam, EMGO+ Institute for Health and Care Research, Amsterdam, the Netherlands.
Jinyan HuangState Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital Affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Haja N KadarmideenDepartment of Veterinary Clinical and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg C, Denmark.
Mika KähönenDepartment of Clinical Physiology, University of Tampere School of Medicine, Tampere, Finland, Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland.
Wieland KiessCenter of Pediatric Research, Department of Women's and Child Health.
Hanna-Maaria LakkaInstitute of Biomedicine, Physiology, University of Eastern Finland, Kuopio, Finland.
Timo A LakkaInstitute of Biomedicine, Physiology, University of Eastern Finland, Kuopio, Finland, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland, Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland.
Alexandra M LewinDepartment of Epidemiology and Biostatistics, MRC Health Protection Agency (HPE) Centre for Environment and Health, School of Public Health, Imperial College London, UK.
Liming LiangDepartment of Epidemiology, Department of Biostatistics, Harvard School of Public Health, Boston, USA.
Leo-Pekka LyytikäinenDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland, Department of Clinical Chemistry.
Baoshan MaCollege of Information Science and Technology, Dalian Maritime University, Dalian, Liaoning Province, China.
Per MagnusDivision of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway.
Shana E McCormackDivision of Human Genetics, Division of Endocrinology, Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
George McMahonMRC Integrative Epidemiology Unit at the University of Bristol.
Frank D MentchCenter for Applied Genomics.
Christel M MiddeldorpDepartment of Biological Psychology, VU University Amsterdam, NCA Neuroscience Campus Amsterdam, EMGO+ Institute for Health and Care Research, Amsterdam, the Netherlands.
Clare S MurrayCentre for Respiratory Medicine and Allergy, Institute of Inflammation and Repair, University of Manchester and University Hospital of South Manchester, Manchester Academic Health Sciences Centre, Manchester, UK.
Katja PahkalaResearch Centre of Applied and Preventive Cardiovascular Medicine, Department of Health and Physical Activity, Paavo Nurmi Centre, Sports and Exercise Medicine Unit.
Tune H PersDivision of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, USA, Medical and Population Genetics Program, Broad Institute of MIT and Harvard, Cambridge, USA.
Roland PfäffleCenter of Pediatric Research, Department of Women's and Child Health, CrescNet, Medical Faculty, University of Leipzig, Germany.
Dirkje S PostmaDepartment of Pulmonology, GRIAC (Groningen Research Institute for Asthma and COPD).
Christine PowerPopulation, Policy and Practice, UCL Institute of Child Health.
Angela SimpsonCentre for Respiratory Medicine and Allergy, Institute of Inflammation and Repair, University of Manchester and.
Verena SengpielDepartment of Obstetrics and Gynecology, Sahlgrenska Academy, Sahlgrenska University Hosptial, Gothenburg, Sweden.
Carla M T TieslerInstitute of Epidemiology I, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany, Division of Metabolic and Nutritional Medicine, Dr von Hauner Children's Hospital, University of Munich Medical Center, Munich, Germany.
Maties TorrentCIBER Epidemiología y Salud Pública (CIBERESP), Spain, Area de Salut de Menorca, ib-salut, Menorca, Spain.
André G UitterlindenThe Generation R Study Group, Department of Epidemiology, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Joyce B van MeursDepartment of Epidemiology, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Rebecca VindingDepartment of Pediatrics, Naestved Hospital, Naestved, Denmark, COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital.
Johannes WaageCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital.
Jane WardleDepartment of Epidemiology and Public Health, University College London, UK.
Eleftheria ZegginiWellcome Trust Sanger Institute, The Morgan Building, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, UK.
Babette S ZemelDivision of Gastroenterology, Hepatology and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, PA, USA, Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
George V DedoussisDepartment of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece.
Oluf PedersenNovo Nordisk Foundation Centre for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Philippe FroguelCNRS UMR8199, Pasteur Institute Lille, France, Department of Genomics of Common Disease, School of Public Health, Imperial College London, Hammersmith Hospital, London, UK.
Jordi SunyerCIBER Epidemiología y Salud Pública (CIBERESP), Spain, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain, Pompeu Fabra University (UPF), Barcelona, Spain, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.
Robert PlominKing's College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, De Crespigny Park, London, UK.
Bo JacobssonDepartment of Genes and Envrionment, Division of Epidemiology, Department of Obstetrics and Gynecology, Sahlgrenska Academy, Sahlgrenska University Hosptial, Gothenburg, Sweden.
Torben HansenNovo Nordisk Foundation Centre for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Juan R GonzalezCIBER Epidemiología y Salud Pública (CIBERESP), Spain, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain, Pompeu Fabra University (UPF), Barcelona, Spain.
Adnan CustovicCentre for Respiratory Medicine and Allergy, Institute of Inflammation and Repair, University of Manchester and University Hospital of South Manchester, Manchester Academic Health Sciences Centre, Manchester, UK.
Olli T RaitakariResearch Centre of Applied and Preventive Cardiovascular Medicine, Department of Clinical Physiology and Nuclear Medicine.
Craig E PennellSchool of Women's and Infants' Health, The University of Western Australia, Perth, Australia.
Elisabeth WidénInstitute for Molecular Medicine, Finland (FIMM), University of Helsinki, Helsinki, Finland.
Dorret I BoomsmaDepartment of Biological Psychology, VU University Amsterdam, NCA Neuroscience Campus Amsterdam, EMGO+ Institute for Health and Care Research, Amsterdam, the Netherlands.
Gerard H KoppelmanDepartment of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children's Hospital, GRIAC (Groningen Research Institute for Asthma and COPD), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Sylvain SebertCentre for Life Course Epidemiology, Biocenter Oulu, University of Oulu, Oulu, Finland.
Marjo-Riitta JärvelinCentre for Life Course Epidemiology, Biocenter Oulu, University of Oulu, Oulu, Finland, Department of Epidemiology and Biostatistics, MRC Health Protection Agency (HPE) Centre for Environment and Health, School of Public Health, Imperial College London, UK, Unit of Primary Care, Oulu University Hospital, Oulu, Finland, Department of Children and Young People and Families, National Institute for Health and Welfare, Oulu, Finland.
Elina HyppönenPopulation, Policy and Practice, UCL Institute of Child Health, School of Population Health and Sansom Institute, University of South Australia, Adelaide, Australia, South Australian Health and Medical Research Institute, Adelaide, Australia.
Mark I McCarthyWellcome Trust Centre for Human Genetics, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK, Oxford National Institute for Health Research (NIHR) Biomedical Research Centre, Churchill Hospital, Oxford, UK.
Virpi LindiInstitute of Biomedicine, Physiology, University of Eastern Finland, Kuopio, Finland.
Niinikoski HarriDepartment of Pediatrics, Turku University Hospital, University of Turku, Turku, Finland.
Antje KörnerCenter of Pediatric Research, Department of Women's and Child Health.
Klaus BønnelykkeCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital.
Joachim HeinrichInstitute of Epidemiology I, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Mads MelbyeDepartment of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA and.
Fernando RivadeneiraThe Generation R Study Group, Department of Epidemiology, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Hakon HakonarsonCenter for Applied Genomics, Division of Human Genetics, Department of Obstetrics and Gynecology, Sahlgrenska Academy, Sahlgrenska University Hosptial, Gothenburg, Sweden.
Susan M RingMRC Integrative Epidemiology Unit at the University of Bristol, Avon Longitudinal Study of Parents and Children (ALSPAC), School of Social and Community Medicine, University of Bristol, Bristol, UK.
George Davey SmithMRC Integrative Epidemiology Unit at the University of Bristol.
Thorkild I A SørensenMRC Integrative Epidemiology Unit at the University of Bristol, Novo Nordisk Foundation Centre for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark, Institute of Preventive Medicine, Bispebjerg and Frederiksberg Hospital, The Capital Region, Copenhagen, Denmark.
Nicholas J TimpsonMRC Integrative Epidemiology Unit at the University of Bristol.
Struan F A GrantCenter for Applied Genomics, Division of Human Genetics, Division of Endocrinology, Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Vincent W V JaddoeThe Generation R Study Group, Department of Pediatrics, Department of Epidemiology.
Early Growth Genetics (EGG) Consortium
Bone Mineral Density in Childhood Study BMDCS

Funding

Type 1 Diabetes Genetics ConsortiumU01DK062418 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI RICH, STEPHEN S. · 2002 to 2007
$59.8M
LCenter for Clinical and Translational Science and TrainingUL1TR001425 · NCATS · UNIVERSITY OF CINCINNATI · PI HEUBI, JAMES E., KISSELA, BRETT M · 2015 to 2024
$37.5M
Translational Research Support CoreP30ES013508 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI Trevor M Penning · 2006 to 2026
$35.3M
Gene-Environment Interactions in an Autism Birth CohortU01NS047537 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LIPKIN, W. IAN · 2003 to 2013
$27.0M
JH/CIDR Genotyping for Genome-Wide Association StudiesU01HG004438 · NHGRI · JOHNS HOPKINS UNIVERSITY · PI VALLE, DAVID · 2007 to 2011
$24.2M
UCSF Nutrition Obesity Research CenterP30DK098722 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jeremy F Reiter · 2015 to 2026
$14.6M
Cell Interactions in the Inflamed Intestinal MucosaR01DK075787 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI JOEL N HIRSCHHORN · 2007 to 2026
$13.1M
Cincinnati Center for Clinical and Translational Sciences and TrainingUL1TR000077 · NCATS · UNIVERSITY OF CINCINNATI · PI HEUBI, JAMES E., TSEVAT, JOEL · 2012 to 2014
$9.9M
Genome Wide Association Study for Childhood ObesityR01HD056465 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI GRANT, STRUAN F A · 2008 to 2024
$9.5M
Genome Wide Association Coordinating CenterU01HG004446 · NHGRI · UNIVERSITY OF WASHINGTON · PI WEIR, BRUCE S. · 2007 to 2011
$6.6M
Bone Mineral Accretion in Young ChildrenR01HD076321 · NICHD · CINCINNATI CHILDRENS HOSP MED CTR · PI KALKWARF, HEIDI J, ZEMEL, BABETTE S · 2013 to 2017
$5.1M
Genetics of cardiovascular risk factors in large founder population birth controlR01HL087679 · NHLBI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI HIRSCHHORN, JOEL N · 2007 to 2009
$4.0M
Biotechnology and Biological Sciences Research CouncilCancer Research UK 14133CIHR MOP-82893Medical Research Council G0000934Medical Research Council G0500079Medical Research Council G0601361Medical Research Council G0802782Medical Research Council G0901245Medical Research Council G19/2Medical Research Council G9815508Medical Research Council MC_PC_15018Medical Research Council MC_UU_12013/1Medical Research Council MC_UU_12013/1-9Medical Research Council MC_UU_12013/3Medical Research Council MR/K002449/1Medical Research Council MR/K002449/2Medical Research Council MR/M012638/1Medical Research Council MR/M013138/1Medical Research Council MR/N01104X/1NCATS NIH HHS UL1 TR000077NCATS NIH HHS UL1 TR001425NCI NIH HHS R01 CA166945NHGRI NIH HHS U01 HG004423NHGRI NIH HHS U01HG004423NHGRI NIH HHS U01 HG004438NHGRI NIH HHS U01HG004438NHGRI NIH HHS U01 HG004446NHGRI NIH HHS U01HG004446NHLBI NIH HHS 5R01HL087679-02NHLBI NIH HHS R01 HL087679NICHD NIH HHS R01 HD056465NICHD NIH HHS R01 HD058886NICHD NIH HHS R01 HD076321NICHD NIH HHS R01 HD58886NIDDK NIH HHS K12 DK094723NIDDK NIH HHS K23 DK102659NIDDK NIH HHS P30 DK098722NIDDK NIH HHS R01 DK075787NIDDK NIH HHS U01 DK062418NIEHS NIH HHS N01 ES075558NIEHS NIH HHS P30 ES013508NIMH NIH HHS 1RL1MH083268-01NIMH NIH HHS 5R01MH63706:02NIMH NIH HHS R01 MH063706NIMH NIH HHS RL1 MH083268NINDS NIH HHS 1 UO1 NS 047537-01NINDS NIH HHS 2 UO1 NS 047537-06A1NINDS NIH HHS U01 NS047537Wellcome Trust 068545/Z/02Wellcome Trust 076113Wellcome Trust 085475/B/08/ZWellcome Trust 085475/Z/08/ZWellcome Trust 090367Wellcome Trust 098381Wellcome Trust 102215Wellcome Trust 102215/2/13/2Wellcome Trust 202802/Z/16/Z
6 · The paper itself

Abstract

A large number of genetic loci are associated with adult body mass index. However, the genetics of childhood body mass index are largely unknown. We performed a meta-analysis of genome-wide association studies of childhood body mass index, using sex- and age-adjusted standard deviation scores. We included 35 668 children from 20 studies in the discovery phase and 11 873 children from 13 studies in the replication phase. In total, 15 loci reached genome-wide significance (P-value < 5 × 10(-8)) in the joint discovery and replication analysis, of which 12 are previously identified loci in or close to ADCY3, GNPDA2, TMEM18, SEC16B, FAIM2, FTO, TFAP2B, TNNI3K, MC4R, GPR61, LMX1B and OLFM4 associated with adult body mass index or childhood obesity. We identified three novel loci: rs13253111 near ELP3, rs8092503 near RAB27B and rs13387838 near ADAM23. Per additional risk allele, body mass index increased 0.04 Standard Deviation Score (SDS) [Standard Error (SE) 0.007], 0.05 SDS (SE 0.008) and 0.14 SDS (SE 0.025), for rs13253111, rs8092503 and rs13387838, respectively. A genetic risk score combining all 15 SNPs showed that each additional average risk allele was associated with a 0.073 SDS (SE 0.011, P-value = 3.12 × 10(-10)) increase in childhood body mass index in a population of 1955 children. This risk score explained 2% of the variance in childhood body mass index. This study highlights the shared genetic background between childhood and adult body mass index and adds three novel loci. These loci likely represent age-related differences in strength of the associations with body mass index.

Indexed as

Body Mass IndexGenome-Wide Association StudyPolymorphism, Single NucleotideAdolescentAdultChildChild, PreschoolFemaleGenetic LociHumansMaleObesityRiskWhite PeopleYoung Adult

Identifiers

PMID26604143
PMCPMC4854022

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