ArticleFertility and sterility2016
Subfertility increases risk of testicular cancer: evidence from population-based semen samples.
Article in Fertility and sterility, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 5 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
54 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Vasectomy and prostate cancer risk: a pooled of cohort studies and Mendelian randomization analysis.BMC cancer · 2025Pooled it
- Adult Organophosphate and Carbamate Insecticide Exposure and Sperm Concentration: A Systematic Review and Meta-Analysis of the Epidemiological Evidence.Environmental health perspectives · 2023Pooled it
- A Systematic Review and Meta-Analysis of Male Infertility and the Subsequent Risk of Cancer.Frontiers in oncology · 2021Pooled it
- Clinical correlation among male infertility and overall male health: A systematic review of the literature.Investigative and clinical urology · 2020Pooled it
- Testicular Cancer in Infertile Men With and Without Testicular Microlithiasis: A Systematic Review and Meta-Analysis of Case-Control Studies.Frontiers in endocrinology · 2019Pooled it
- Spontaneous miscarriage after intracytoplasmic sperm injection with frozen sperm of patients with testicular germ cell tumour.BJU international · 2026Article
- Mapping whole-organism genetic comorbidities across model Species using unified ontologies.Genetics · 2026Article
- Risk of non-reproductive cancer in men from couples conceiving through assisted reproduction: a Swedish nation-based register study.European journal of epidemiology · 2026Article
- Neonatal characteristics of children conceived with in vitro fertilization or intrauterine insemination compared with sibling births from unassisted conceptions.Fertility and sterility · 2026Article
- Male infertility and risk of cardiometabolic conditions: a population-based cohort study.Human reproduction (Oxford, England) · 2026Article
- Unlocking the power of semen analysis in primary health care - a path to men's health and lifestyle transformation.Nature reviews. Urology · 2025Review
- The Evolving Molecular Landscape and Actionable Alterations in Urologic Cancers.Current oncology (Toronto, Ont.) · 2024Review
- Refractory testicular germ cell tumors are highly sensitive to the targeting of polycomb pathway demethylases KDM6A and KDM6B.Cell communication and signaling : CCS · 2024Article
- Male Fertility as a Proxy for Health.Journal of clinical medicine · 2024Review
- Incidental seminoma in nonobstructive azoospermia: a case report.F&S reports · 2024Article
- Interplay between male gonadal function and overall male health.Journal of basic and clinical physiology and pharmacology · 2024Review
- Describing patterns of familial cancer risk in subfertile men using population pedigree data.Human reproduction (Oxford, England) · 2024Article
- Article
- Frequency, morbidity and equity - the case for increased research on male fertility.Nature reviews. Urology · 2024Review
- Lab-based semen parameters as predictors of long-term health in men-a systematic review.Human reproduction open · 2024Review
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Authors and funding
6 authors.
Funding
Abstract
objectiveTo further understand the association between semen quality and cancer risk by means of well defined semen parameters.
designRetrospective cohort study.
settingNot applicable. PATIENT(S): A total of 20,433 men who underwent semen analysis (SA) and a sample of 20,433 fertile control subjects matched by age and birth year. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Risk of all cancers as well as site-specific results for prostate cancer, testicular cancer, and melanoma. RESULT(S): Compared with fertile men, men with SA had an increased risk of testicular cancer (hazard rate [HR] 3.3). When the characterization of infertility was refined using individual semen parameters, we found that oligozoospermic men had an increased risk of cancer compared with fertile control subjects. This association was particularly strong for testicular cancer, with increased risk in men with oligozoospermia based on concentration (HR 11.9) and on sperm count (HR 10.3). Men in the in the lowest quartile of motility (HR 4.1), viability (HR 6.6), morphology (HR 4.2), or total motile count (HR 6.9) had higher risk of testicular cancer compared with fertile men. Men with sperm concentration and count in the 90th percentiles of the distribution (≥178 and ≥579 × 10(6)/mL, respectively), as well as total motile count, had an increased risk of melanoma (HRs 2.1, 2.7, and 2.0, respectively). We found no differences in cancer risk between azoospermic and fertile men. CONCLUSION(S): Men with SA had an increased risk of testicular cancer which varied by semen quality. Unlike earlier work, we did not find an association between azoospermia and increased cancer risk.
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