Evidence map›Paper›PMID 26603900›Full record

ReviewNature reviews. Immunology2015

New insights into the immunopathology and control of dengue virus infection.

Gavin Screaton, Juthathip Mongkolsapaya, Sophie Yacoub, Catherine Roberts

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 210 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
210citing papers in PubMed, 3 pooled it
48.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

210 citing papers in PubMed, 3 syntheses or guidelines pooled it, 382 citations in OpenAlex.

  1. Pooled it
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  8. Cost-Effectiveness of the Strategies to Reduce the Incidence of Dengue in Colima, México.International journal of environmental research and public health · 2017
    Trial
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150 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 2 countries.

Gavin ScreatonDivision of Immunology and Inflammation, Department of Medicine, Hammersmith campus, Imperial College London, London W12 0NN, UK.
Juthathip MongkolsapayaDivision of Immunology and Inflammation, Department of Medicine, Hammersmith campus, Imperial College London, London W12 0NN, UK.
Sophie YacoubDivision of Immunology and Inflammation, Department of Medicine, Hammersmith campus, Imperial College London, London W12 0NN, UK.
Catherine RobertsDivision of Immunology and Inflammation, Department of Medicine, Hammersmith campus, Imperial College London, London W12 0NN, UK.
Imperial College London · GB

Funding

Medical Research Council G0600000Medical Research Council G0801508Wellcome Trust 095541
6 · The paper itself

Abstract

Dengue virus poses a major threat to global public health: two-thirds of the world's population is now at risk from infection by this mosquito-borne virus. Dengue virus causes a range of diseases with a small proportion of infected patients developing severe plasma leakage that leads to dengue shock syndrome, organ impairment and bleeding. Infection with one of the four viral serotypes results in the development of homotypic immunity to that serotype. However, subsequent infection with a different serotype is associated with an increased risk of developing severe disease, which has led to the suggestion that severe disease is triggered by immunopathology. This Review outlines recent advances in the understanding of immunopathology, vaccine development and human monoclonal antibodies produced against dengue virus.

Indexed as

Antibodies, MonoclonalDengueDengue VaccinesDengue VirusHost-Pathogen InteractionsHumansLife Cycle StagesModels, ImmunologicalT-LymphocytesAntibodies, MonoclonalDengue Vaccines

Identifiers

PMID26603900
OpenAlexW2181263624

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.