ArticleScientific reports2015
A new application of click chemistry in situ: development of fluorescent probe for specific G-quadruplex topology.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Kinetic Target-Guided Synthesis of Small-Molecule G-Quadruplex Stabilizers.ChemistryOpen · 2020Article
- More is not always better: finding the right trade-off between affinity and selectivity of a G-quadruplex ligand.Nucleic acids research · 2018Article
- Natural Alkaloids and Heterocycles as G-Quadruplex Ligands and Potential Anticancer Agents.Molecules (Basel, Switzerland) · 2018Review
- Structure-Affinity Relationships and Structure-Kinetics Relationships of Pyrido[2,1-f]purine-2,4-dione Derivatives as Human Adenosine AJournal of medicinal chemistry · 2017Article
- Target guided synthesis using DNA nano-templates for selectively assembling a G-quadruplex binding c-MYC inhibitor.Nature communications · 2017Article
- Chiral metallohelices enantioselectively target hybrid human telomeric G-quadruplex DNA.Nucleic acids research · 2017Article
- Specific targeting of telomeric multimeric G-quadruplexes by a new triaryl-substituted imidazole.Nucleic acids research · 2017Article
- A red-NIR fluorescent dye detecting nuclear DNA G-quadruplexes: in vitro analysis and cell imaging.Chemical communications (Cambridge, England) · 2017Article
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Authors and funding
8 authors.
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Abstract
Target-guided synthesis is an approach to drug discovery that allows the target to self-assemble its own binding agents. So far, target-guided synthesis and especially in situ click chemistry have attracted extensive attention and have led to the identification of highly potent inhibitors for proteins. In this study, we expand the application of in situ click chemistry and present a procedure using this approach to identify selective fluorescent probes for a specific topology of G-quadruplex nucleic acids, the parallel G-quadruplexes. On this basis, compound 15 assembled by triarylimidazole scaffold and carboxyl side chain was a positive hit, demonstrating highly potential in the sensitive and selective detection of parallel G-quadruplexes. Such selective fluorescence response can be rationalized in terms of different binding affinities between 15 and G-quadruplexes. Our work accordingly represents a new development towards the application of in situ click chemistry to develop selective fluorescent probes and may also shed light on the search for probes for a specific G-quadruplex topology.
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