ArticlePhysiological reports2015
Relationships between inflammatory cytokine and cortisol responses in firefighters exposed to simulated wildfire suppression work and sleep restriction.
Article in Physiological reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Stress-mediating inflammatory cytokine profiling reveals unique patterns in malaria and typhoid fever patients.PloS one · 2025Observational
- A Prospective Cohort Study on the Effects of Repeated Acute Stress on Cortisol Awakening Response and Immune Function in Military Medical Students.Biomedicines · 2024Article
- Cortisol and cytokines in schizophrenia: A scoping review.Comprehensive psychoneuroendocrinology · 2023Article
- A Study of Diurnal Cortisol Adaptations in Sleep-Deprived Firefighters During a 72-Hour Work Shift: A Case Series.Cureus · 2023Article
- Characterising Psycho-Physiological Responses and Relationships during a Military Field Training Exercise.International journal of environmental research and public health · 2022Article
- Working hours, sleep, and fatigue in the public safety sector: A scoping review of the research.American journal of industrial medicine · 2022Article
- Sleep of recruits throughout basic military training and its relationships with stress, recovery, and fatigue.International archives of occupational and environmental health · 2022Article
- Article
- Health risks and mitigation strategies from occupational exposure to wildland fire: a scoping review.Journal of occupational medicine and toxicology (London, England) · 2022Article
- Prenatal immune stimulation alters the postnatal acute phase and metabolic responses to an endotoxin challenge in weaned beef heifersTranslational animal science · 2021Article
- The influence of TNF-α on the expression profile of key enzymes of steroidogenesis in H295R cells.Postepy dermatologii i alergologii · 2021Article
- Hot, Tired and Hungry: The Snacking Behaviour and Food Cravings of Firefighters During Multi-Day Simulated Wildfire Suppression.Nutrients · 2020Article
- Network between Cytokines, Cortisol and Occupational Stress in Gas and Oilfield Workers.International journal of molecular sciences · 2020Article
- Wildland Firefighting: Adverse Influence on Indices of Metabolic and Cardiovascular Health.Journal of occupational and environmental medicine · 2019Article
- Network topology dynamics of circulating biomarkers and cognitive performance in older Cytomegalovirus-seropositive or -seronegative men and women.Immunity & ageing : I & A · 2019Article
- Treatment of a Woman WithJournal of chiropractic medicine · 2018Article
- Academic stress-induced changes in Th1- and Th2-cytokine response.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2017Article
- Diurnal Hypothalamic-Pituitary-Adrenal Axis Measures and Inflammatory Marker Correlates in Major Depressive Disorder.International journal of molecular sciences · 2017Article
- Insights into the molecular mechanisms of stress and inflammation in ageing and frailty of the elderly.Journal of molecular biochemistry · 2017Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The interplay between inflammatory and cortisol responses modulates an appropriate response to a stressor. Exposure to severe stressors, however, may alter the actions and relationships of these responses and contribute to negative health outcomes. Physical work and sleep restriction are two stressors faced by wildland firefighters, yet their influence on the relationship between inflammatory and cortisol responses is unknown. The aim of the present study was to quantify the relationship between the cytokine and cortisol responses to sleep restriction while performing simulated physical wildfire suppression work. Firefighters completed 3 days of simulated physical firefighting work separated by either an 8-h (Control condition; n = 18) or 4-h sleep (Sleep restriction condition; n = 17) opportunity on each of the two nights. Salivary cortisol and inflammatory cytokines (IL-6, IL-8, IL-1β, TNF-α, IL-4, and IL-10) were measured throughout each day. An increase in morning IL-6 was related to a rise (6.2%, P = 0.043) in evening cortisol among firefighters in the sleep restriction condition. Higher morning IL-6 levels were related to increased (5.3%, P = 0.048) daily cortisol levels, but this relationship was not different between conditions. Less pronounced relationships were demonstrated between TNF-α, IL-10, IL-4, and cortisol independent of the sleep opportunity, but relationships did not persist after adjusting for demographic factors and other cytokines. These findings quantify the relationship between cytokine and cortisol responses among wildland firefighters exposed to simulated occupational stressors. Potential disturbances to the IL-6 and cortisol relationship among sleep-restricted firefighters' supports further investigations into the negative health effects related to possible imbalances between these systems.
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