ArticleDevelopment (Cambridge, England)2016
Hypothalamic radial glia function as self-renewing neural progenitors in the absence of Wnt/β-catenin signaling.
Article in Development (Cambridge, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Wnt/β-catenin signaling promotes neurogenesis in the diencephalospinal dopaminergic system of embryonic zebrafish.Scientific reports · 2022Article
- β-Catenin Deletion in Regional Neural Progenitors Leads to Congenital Hydrocephalus in Mice.Neuroscience bulletin · 2022Article
- Dopaminergic neurons regenerate following chemogenetic ablation in the olfactory bulb of adult Zebrafish (Danio rerio).Scientific reports · 2020Article
- Article
- Fgf3 is crucial for the generation of monoaminergic cerebrospinal fluid contacting cells in zebrafish.Biology open · 2019Article
- WNT/NOTCH Pathway Is Essential for the Maintenance and Expansion of Human MGE Progenitors.Stem cell reports · 2019Article
- Midbrain tectal stem cells display diverse regenerative capacities in zebrafish.Scientific reports · 2019Article
- Cellular fate decisions in the developing female anteroventral periventricular nucleus are regulated by canonical Notch signaling.Developmental biology · 2018Article
- Lef1-dependent hypothalamic neurogenesis inhibits anxiety.PLoS biology · 2017Article
- Development of the hypothalamus: conservation, modification and innovation.Development (Cambridge, England) · 2017Review
- Delineating the Common Biological Pathways Perturbed by ASD's Genetic Etiology: Lessons from Network-Based Studies.International journal of molecular sciences · 2017Review
- Gene expression and proliferation biomarkers for antidepressant treatment resistance.Translational psychiatry · 2017Article
- Motor Behavior Mediated by Continuously Generated Dopaminergic Neurons in the Zebrafish Hypothalamus Recovers after Cell Ablation.Current biology : CB · 2016Article
- Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The vertebrate hypothalamus contains persistent radial glia that have been proposed to function as neural progenitors. In zebrafish, a high level of postembryonic hypothalamic neurogenesis has been observed, but the role of radial glia in generating these new neurons is unclear. We have used inducible Cre-mediated lineage labeling to show that a population of hypothalamic radial glia undergoes self-renewal and generates multiple neuronal subtypes at larval stages. Whereas Wnt/β-catenin signaling has been demonstrated to promote the expansion of other stem and progenitor cell populations, we find that Wnt/β-catenin pathway activity inhibits this process in hypothalamic radial glia and is not required for their self-renewal. By contrast, Wnt/β-catenin signaling is required for the differentiation of a specific subset of radial glial neuronal progeny residing along the ventricular surface. We also show that partial genetic ablation of hypothalamic radial glia or their progeny causes a net increase in their proliferation, which is also independent of Wnt/β-catenin signaling. Hypothalamic radial glia in the zebrafish larva thus exhibit several key characteristics of a neural stem cell population, and our data support the idea that Wnt pathway function may not be homogeneous in all stem or progenitor cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.