Evidence map›Paper›PMID 26603245›Full record

Trial reportBMJ open2015

Effect of increased water intake on plasma copeptin in patients with chronic kidney disease: results from a pilot randomised controlled trial.

Jessica M Sontrop, Shi-Han Huang, Amit X Garg, Louise Moist, Andrew A House, Kerri Gallo, William F Clark

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMJ open, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01753466 (The Water Intake Trial), which is not on this map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01753466 phase3completednot on this map

The Water Intake Trial: Pilot Phase

TypeinterventionalSponsorLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph'sRan2012 to 2013Enrolled33ConditionsChronic Kidney DiseaseArmsHydration
3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Jessica M SontropDivision of Nephrology, Department of Medicine, London Health Sciences Centre, London, Ontario, Canada Department of Epidemiology & Biostatistics, Western University, London, Ontario, Canada.
Shi-Han HuangDivision of Nephrology, Department of Medicine, London Health Sciences Centre, London, Ontario, Canada.
Amit X GargDivision of Nephrology, Department of Medicine, London Health Sciences Centre, London, Ontario, Canada Department of Epidemiology & Biostatistics, Western University, London, Ontario, Canada.
Louise MoistDivision of Nephrology, Department of Medicine, London Health Sciences Centre, London, Ontario, Canada Department of Epidemiology & Biostatistics, Western University, London, Ontario, Canada.
Andrew A HouseDivision of Nephrology, Department of Medicine, London Health Sciences Centre, London, Ontario, Canada.
Kerri GalloDivision of Nephrology, Department of Medicine, London Health Sciences Centre, London, Ontario, Canada.
William F ClarkDivision of Nephrology, Department of Medicine, London Health Sciences Centre, London, Ontario, Canada.
London Health Sciences Centre · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesIncreased water intake may have a beneficial effect on the kidney through suppression of plasma vasopressin. We examined the effect of increased water intake on plasma copeptin (a marker of vasopressin) over 6 weeks in patients with chronic kidney disease.

designSecondary analysis of a randomised controlled parallel-group pilot trial.

settingCanada, 2012-2013.

participants28 patients with stage 3 chronic kidney disease randomised (2:1) to a hydration (n=17) or control group (n=11).

interventionThe hydration group was coached to increase water intake by up to 1.5 L/day for 6 weeks. The control group was asked to maintain regular water intake. MEASURES AND OUTCOMES: Participants provided blood and 24 h urine samples at baseline and 6 weeks. Change in plasma copeptin was compared within and between study groups.

resultsParticipants were 64% male with a mean age of 62 years and an estimated glomerular filtration rate of 40 mL/min/1.73 m(2). Between baseline and 6 weeks, 24 h urine volume increased by 0.7 L/day in the hydration group, rising from 2.3 to 3.0 L/day (p=0.01), while decreasing by 0.3 L/day among controls, from 2.0 to 1.7 L/day (p=0.07); between-group difference: 0.9 L/day (95% CI 0.37 to 1.46; p=0.002). In the hydration group, median copeptin decreased by 3.6 pmol/L, from 15.0 to 10.8 pmol/L (p=0.005), while remaining stable among controls at 19 pmol/L (p=0.76; p=0.19 for the between-group difference in median change); the between-group difference in mean change was 5.4 pmol/L (95% CI -1.2 to 12.0; p=0.11).

conclusionsAdults with stage 3 chronic kidney disease can be successfully randomised to drink approximately 1 L more per day than controls. This increased water intake caused a significant decrease in plasma copeptin concentration. Our larger 12-month trial will examine whether increased water intake can slow renal decline in patients with chronic kidney disease. TRIAL REGISTRATION NUMBER: NCT01753466.

Indexed as

DrinkingAgedBiomarkersCanadaFemaleGlomerular Filtration RateGlycopeptidesHumansKidneyMaleMiddle AgedRenal Insufficiency, ChronicBiomarkerscopeptinsGlycopeptides24-hour urine volumechronic kidney diseasecoeptinglomerular filtration ratewater intake

Identifiers

PMID26603245
PMCPMC4663439
OpenAlexW2178826968

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.