ArticleBMC gastroenterology2015
Prognostic impact of immunohistochemical expression of CK7 and CK20 in curatively resected ampulla of Vater cancer.
Article in BMC gastroenterology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 25 citations in OpenAlex.
- Not All Painless Jaundice in the Elderly Is Primary Pancreatic Cancer.Case reports in oncological medicine · 2026Article
- Oncologic effect of preoperative endoscopic sphincterotomy in patients undergoing pancreaticoduodenectomy for ampulla of vater cancer.Langenbeck's archives of surgery · 2025Article
- Defying the Prognostic Odds: A Case Report of Unexpected Complete Remission of Metastatic Ampullary Carcinoma With Palliative Chemotherapy.Case reports in oncological medicine · 2025Article
- Multimodal treatment of oligometastatic non-small cell lung cancer.BMJ case reports · 2023Article
- Ampullary Cancer: Histological Subtypes, Markers, and Clinical Behaviour-State of the Art and Perspectives.Current oncology (Toronto, Ont.) · 2023Review
- Targeted BRAF Inhibitor Therapy Induces Remission of Unresectable Ampullary Adenocarcinoma.ACG case reports journal · 2022Article
- Indicative value of pathological classification of duodenal papillary adenomas in clinical diagnosis and treatment.Surgical endoscopy · 2022Article
- Ampullary carcinoma of the duodenum: current clinical issues and genomic overview.Surgery today · 2022Review
- Association between Immunohistochemistry Markers and Tumor Features and Their Diagnostic and Prognostic Values in Intrahepatic Cholangiocarcinoma.Computational and mathematical methods in medicine · 2022Article
- Prognostic Factors of Long-term Survival Following Radical Resection for Ampullary Carcinoma.Journal of gastrointestinal cancer · 2021Article
- Very early recurrence following pancreaticoduodenectomy in patients with ampullary cancer.Medicine · 2019Article
- Durable response for ampullary and duodenal adenocarcinoma with a nab-paclitaxel plus gemcitabine ± cisplatin combination.Cancer medicine · 2019Article
- Identification of relevant prognostic values of cytokeratin 20 and cytokeratin 7 expressions in lung cancer.Bioscience reports · 2017Article
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2 authors at 1 institution in 1 country.
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Abstract
backgroundIn the consideration of ampullary adenocarcinoma, T stage, lymph node metastases, perineural invasion, tumor differentiation, pancraticobiliary type, and lymph node ratio are considered prognostic factors. The objectives of this study were to investigate surgical outcomes and the clinicopathological predictors affecting survival and recurrence, and to examine the prognostic roles of histopathological subtype and immunohistochemical markers.
methodsFrom April 2006 to September 2012, 37 patients who underwent curative resection of ampullar of Vater adenocarcinoma were enrolled in this study. A retrospective review was performed based on medical records. Immunohistochemical expression, histopathological type and clinicopathologic factors were analyzed.
resultsThe 5-year overall survival rates and disease-free survival rates after surgery were 77.4 and 75.7 %, respectively. Multivariate Cox regression analysis showed that advanced T stage (p = 0.019) and positive expression of Cytokeratin 7 (CK7) with negative expression of Cytokeratin 20 (CK20) (p = 0.046) were identified as significant independent factors related to survival, and poor differentiation (p = 0.031) significantly influenced disease-free survival in multivariate analysis.
conclusionsAdvanced T stage is a significant prognostic factor affecting survival in ampullary adenocarcinoma. Also, positive expression of CK7 with negative expression of CK20 is an independent factor related to overall survival.
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