ArticleScientific reports2015
Ex vivo peripheral nerve detection of rats by spontaneous Raman spectroscopy.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 41 citations in OpenAlex.
- Spatially multiplexed random-access Raman probe for in vivo tissue measurements.Biomedical optics express · 2026Article
- Laparoscopic hyperspectral imaging for in vivo detection of the vagal nerve in upper gastrointestinal surgery.Surgical endoscopy · 2025Article
- Window into the mind: Advanced handheld spectroscopic eye-safe technology for point-of-care neurodiagnostic.Science advances · 2023Article
- Image-guided cancer surgery: a narrative review on imaging modalities and emerging nanotechnology strategies.Journal of nanobiotechnology · 2023Review
- Recent Advances in Raman Spectral Imaging in Cell Diagnosis and Gene Expression Prediction.Genes · 2022Review
- Raman spectroscopy and sciatic functional index (SFI) after low-level laser therapy (LLLT) in a rat sciatic nerve crush injury model.Lasers in medical science · 2022Article
- The complementary value of intraoperative fluorescence imaging and Raman spectroscopy for cancer surgery: combining the incompatibles.European journal of nuclear medicine and molecular imaging · 2022Review
- Label-free Assessment of the Nascent State of Rat Non-alcoholic Fatty Liver Disease Using Spontaneous Raman Microscopy.Acta histochemica et cytochemica · 2022Article
- Molecular imaging analysis of microvesicular and macrovesicular lipid droplets in non-alcoholic fatty liver disease by Raman microscopy.Scientific reports · 2020Article
- Biochemical changes in injured sciatic nerve of rats after low-level laser therapy (660 nm and 808 nm) evaluated by Raman spectroscopy.Lasers in medical science · 2019Article
- Label-free Evaluation of Myocardial Infarct in Surgically Excised Ventricular Myocardium by Raman Spectroscopy.Scientific reports · 2018Article
- Label-free Molecular Imaging and Analysis by Raman Spectroscopy.Acta histochemica et cytochemica · 2018Article
- Coherent anti-Stokes Raman scattering rigid endoscope toward robot-assisted surgery.Biomedical optics express · 2018Article
- Rapid and accurate peripheral nerve imaging by multipoint Raman spectroscopy.Scientific reports · 2017Article
- Label-free detection of myocardial ischaemia in the perfused rat heart by spontaneous Raman spectroscopy.Scientific reports · 2017Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nerve-sparing surgery is increasingly being applied to avoid functional deficits of the limbs and organs following surgery. Peripheral nerves that should be preserved are, however, sometimes misidentified due to similarity of shape and color to non-nerve tissues. To avoid misidentification of peripheral nerves, development of an in situ nerve detection method is desired. In this study, we report the label-free detection of ex vivo peripheral nerves of Wistar rats by using Raman spectroscopy. We obtained Raman spectra of peripheral nerves (myelinated and unmyelinated nerves) and their adjacent tissues of Wistar rats without any treatment such as fixation and/or staining. For the identification of tissue species and further analysis of spectral features, we proposed a principal component regression-based discriminant analysis with representative Raman spectra of peripheral nerves and their adjacent tissues. Our prediction model selectively detected myelinated nerves and unmyelinated nerves of Wistar rats with respective sensitivities of 95.5% and 88.3% and specificities of 99.4% and 93.5%. Furthermore, important spectral features for the identification of tissue species were revealed by detailed analysis of principal components of representative Raman spectra of tissues. Our proposed approach may provide a unique and powerful tool for peripheral nerve detection for nerve-sparing surgery in the future.
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