ArticleClinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology2016
Serological, genomic and structural analyses of the major mite allergen Der p 23.
Article in Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
45 citing papers in PubMed, 88 citations in OpenAlex.
- Limited impact of Der p 23 IgE on treatment outcomes in tablet allergy immunotherapy phase III study.Allergy · 2021Trial
- Der p 23, A Frequent IgE Sensitizer in Humans, Induces Airway Inflammation in Mice.International journal of molecular sciences · 2025Article
- A digital ELISA for multiplexed detection of allergen-specific IgE against Der p 1, Der p 2, and Der p 23.Bioengineering & translational medicine · 2025Article
- Early Changes in House Dust Mite Component Specific Immunoglobulin Levels Predict the One-Year Efficacy of Allergen Immunotherapy in Patients With Allergic Rhinitis.Clinical and translational allergy · 2025Article
- Identification of the primary sensitizing mite (dominant mite) in patients with allergic respiratory disease sensitized toThe World Allergy Organization journal · 2025Article
- From skin testing to molecular diagnostics: the precision leap in dust mite allergy diagnosis and clinical translation challenges.Frontiers in allergy · 2025Review
- Exploring the Role of Allergenic Components in Children with House Dust Mite-Induced Allergic Diseases.Journal of asthma and allergy · 2025Article
- Allergic sensitization in the tropics: unravelling co-sensitization between crustacean and mites.Frontiers in allergy · 2025Article
- Review
- Structural analysis of human IgE monoclonal antibody epitopes on dust mite allergen Der p 2.The Journal of allergy and clinical immunology · 2024Article
- Advocacy of Precision Allergy Molecular Diagnosis in Decision Making for the Eligibility of Customized Allergen Immunotherapy.Current issues in molecular biology · 2023Article
- Structural basis of EHEP-mediated offense against phlorotannin-induced defense from brown algae to protecteLife · 2023Article
- [Profiles of IgE sensitization to dust mite allergen components in patients with allergic rhinitis and asthma].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2022Article
- Discovery of archaeal fusexins homologous to eukaryotic HAP2/GCS1 gamete fusion proteins.Nature communications · 2022Article
- Human IgE monoclonal antibody recognition of mite allergen Der p 2 defines structural basis of an epitope for IgE cross-linking and anaphylaxisPNAS nexus · 2022Article
- Effect of air filtration on house dust mite, cat and dog allergens and particulate matter in homes.Clinical and translational allergy · 2022Article
- Allergens and their associated small molecule ligands-their dual role in sensitization.Allergy · 2021Review
- IgE-binding residues analysis of the house dust mite allergen Der p 23.Scientific reports · 2021Article
- IgE Epitopes of the House Dust Mite Allergen Der p 7 Are Mainly Discontinuous and Conformational.Frontiers in immunology · 2021Article
- Lessons in Innate and Allergic Immunity From Dust Mite Feces and Tick Bites.Frontiers in allergy · 2021Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundDer p 23 was recently identified in a European population as a major allergen and potentially a chitin binding protein.
objectiveThis study sought to assess the importance of Der p 23 among other Dermatophagoides allergens in a North American population and to determine the structure for functional characterization.
methodsIgE binding to Der p 23, Der p 1, Der p 2, Der p 5, Der p 7 and Der p 8 was measured by ELISA. RNA-seq data from D. pteronyssinus were compared as estimates of allergen expression levels. The structure was analysed by X-ray crystallography and NMR.
resultsDespite a high prevalence of Der p 23, (75% vs. 87% and 79% for Der p 1 and Der p 2, respectively), the anti-Der p 23 IgE levels were relatively low. The patient response to the 6 allergens tested was variable (n = 47), but on average anti-Der p 1 and anti-Der p 2 together accounted for 85% of the specific IgE. In terms of abundance, the RNA expression level of Der p 23 is the lowest of the major allergens, thirty fold less than Der p 1 and sevenfold less than Der p 2. The structure of Der p 23 is a small, globular protein stabilized by two disulphide bonds, which is structurally related to allergens such as Blo t 12 that contain carbohydrate binding domains that bind chitin. Functional assays failed to confirm chitin binding by Der p 23. CONCLUSIONS AND CLINICAL RELEVANCE: Der p 23 accounts for a small percentage of the IgE response to mite allergens, which is dominated by Der p 1 and Der p 2. The prevalence and amount of specific IgE to Der p 23 and Der p 2 are disproportionately high compared to the expression of other Dermatophagoides allergens.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.