Evidence map›Paper›PMID 26602690›Full record

ArticleNucleic acids research2016

Aging Chart: a community resource for rapid exploratory pathway analysis of age-related processes.

Alexey Moskalev, Svetlana Zhikrivetskaya, Mikhail Shaposhnikov, Evgenia Dobrovolskaya, Roman Gurinovich, Oleg Kuryan, Aleksandr Pashuk, Leslie C Jellen, Alex Aliper, Alex Peregudov and 1 more

Abstract read
In one paragraph

Article in Nucleic acids research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Alexey MoskalevLaboratory of molecular radiobiology and gerontology, Institute of Biology of Komi Science Center of Ural Branch of Russian Academy of Sciences, Syktyvkar, 167982, Russia Laboratory of genetics of aging and longevity, Moscow Institute of Physics and Technology, Dolgoprudny, 141700, Russia Laboratory of postgenomic studies, Engelhardt Institute of Molecular Biology of Russian Academy of Sciences, Moscow, 119991, Russia School of Systems Biology, George Mason University, VA, Manassas, 20110, USA Branch of N.I.Pirogov Russian State Medical University "Scientific Clinical Center of Gerontology", Moscow, 117997, Russia amoskalev@list.ru.
Svetlana ZhikrivetskayaLaboratory of genetics of aging and longevity, Moscow Institute of Physics and Technology, Dolgoprudny, 141700, Russia Laboratory of postgenomic studies, Engelhardt Institute of Molecular Biology of Russian Academy of Sciences, Moscow, 119991, Russia.
Mikhail ShaposhnikovLaboratory of molecular radiobiology and gerontology, Institute of Biology of Komi Science Center of Ural Branch of Russian Academy of Sciences, Syktyvkar, 167982, Russia.ORCID http://orcid.org/0000-0002-4625-6488
Evgenia DobrovolskayaLaboratory of molecular radiobiology and gerontology, Institute of Biology of Komi Science Center of Ural Branch of Russian Academy of Sciences, Syktyvkar, 167982, Russia.ORCID http://orcid.org/0000-0001-6090-8254
Roman GurinovichXpansa, Conzl OU, Mustamae Tee 5, Tallinn, 10616, Estonia Infinity Sciences, Inc, 16192 Coastal Highway, Lewes, Delaware, County of Sussex, 19958, USA amoskalev@list.ru.ORCID http://orcid.org/0000-0002-9985-9493
Oleg KuryanXpansa, Conzl OU, Mustamae Tee 5, Tallinn, 10616, Estonia Infinity Sciences, Inc, 16192 Coastal Highway, Lewes, Delaware, County of Sussex, 19958, USA.
Aleksandr PashukXpansa, Conzl OU, Mustamae Tee 5, Tallinn, 10616, Estonia Infinity Sciences, Inc, 16192 Coastal Highway, Lewes, Delaware, County of Sussex, 19958, USA.ORCID http://orcid.org/0000-0001-6551-7658
Leslie C JellenGenetics, Genomics, and Informatics, University of Tennessee Health Science Center, Memphis, TN, 38163, USA.
Alex AliperD.Rogachev FRC Center for Pediatric Hematology, Oncology and Immunology, Samory Machela 1, Moscow, 117997, Russia Insilico Medicine, Inc, Johns Hopkins University, ETC, B310, Baltimore, MD, 21218, USA.
Alex PeregudovThe Biogerontology Research Foundation, 2354 Chynoweth House, Trevissome Park, Blackwater, Truro, Cornwall TR4 8UN, UK.
Alex ZhavoronkovLaboratory of genetics of aging and longevity, Moscow Institute of Physics and Technology, Dolgoprudny, 141700, Russia D.Rogachev FRC Center for Pediatric Hematology, Oncology and Immunology, Samory Machela 1, Moscow, 117997, Russia Insilico Medicine, Inc, Johns Hopkins University, ETC, B310, Baltimore, MD, 21218, USA The Biogerontology Research Foundation, 2354 Chynoweth House, Trevissome Park, Blackwater, Truro, Cornwall TR4 8UN, UK amoskalev@list.ru.ORCID http://orcid.org/0000-0001-7067-8966

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aging research is a multi-disciplinary field encompassing knowledge from many areas of basic, applied and clinical research. Age-related processes occur on molecular, cellular, tissue, organ, system, organismal and even psychological levels, trigger the onset of multiple debilitating diseases and lead to a loss of function, and there is a need for a unified knowledge repository designed to track, analyze and visualize the cause and effect relationships and interactions between the many elements and processes on all levels. Aging Chart (http://agingchart.org/) is a new, community-curated collection of aging pathways and knowledge that provides a platform for rapid exploratory analysis. Building on an initial content base constructed by a team of experts from peer-reviewed literature, users can integrate new data into biological pathway diagrams for a visible, intuitive, top-down framework of aging processes that fosters knowledge-building and collaboration. As the body of knowledge in aging research is rapidly increasing, an open visual encyclopedia of aging processes will be useful to both the new entrants and experts in the field.

Indexed as

Databases, FactualAgingDiseaseHumansSignal Transduction

Identifiers

PMID26602690
PMCPMC4702909

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.