Evidence map›Paper›PMID 26602302›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2015

Assessing the Intestinal Microbiota in the SHINE Trial.

Ethan K Gough, Andrew J Prendergast, Kuda E Mutasa, Rebecca J Stoltzfus, Amee R Manges, Sanitation Hygiene Infant Nutrition Efficacy (SHINE) Trial Team

Abstract read
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. The association between gut microbiome and growth in infants with cystic fibrosis.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2023
    Article
  3. Article
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ethan K GoughDepartment of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada.
Andrew J PrendergastZvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe Blizard Institute, Queen Mary University of London, United Kingdom.
Kuda E MutasaZvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.
Rebecca J StoltzfusDivision of Nutritional Sciences, Cornell University, Ithaca, New York.
Amee R MangesSchool of Population and Public Health, University of British Columbia, Vancouver, Canada.
Sanitation Hygiene Infant Nutrition Efficacy (SHINE) Trial Team

Funding

Effect of a sanitation & nutrition intervention on HIV-exposed infant healthR01HD060338 · NICHD · JOHNS HOPKINS UNIVERSITY · PI HUMPHREY, JEAN HAWES · 2008 to 2012
$2.0M
NICHD NIH HHS 2R01HD060338-06NICHD NIH HHS R01 HD060338Wellcome Trust 093768/Z/10/ZWellcome Trust 100714
6 · The paper itself

Abstract

Advances in DNA sequencing technology now allow us to explore the dynamics and functions of the microbes that inhabit the human body, the microbiota. Recent studies involving experimental animal models suggest a role of the gut microbiota in growth. However, the specific changes in the human gut microbiota that contribute to growth remain unclear, and studies investigating the gut microbiota as a determinant of environmental enteric dysfunction (EED) and child stunting are lacking. In this article, we review the evidence for a link between the developing infant gut microbiota, infant feeding, EED, and stunting, and discuss the potential causal pathways relating these variables. We outline the analytic approaches we will use to investigate these relationships, by capitalizing on the longitudinal design and randomized interventions of the Sanitation Hygiene Infant Nutrition Efficacy trial in Zimbabwe.

Indexed as

Gastrointestinal MicrobiomeGrowth DisordersInfant Nutritional Physiological PhenomenaIntestinesDietFemaleHumansInfantMaleMolecular TypingRandomized Controlled Trials as TopicResearch DesignRural PopulationSequence Analysis, DNAZimbabweenvironmental enteric dysfunctioninfantmicrobiotastunting

Identifiers

PMID26602302
PMCPMC4657595

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.