Evidence map›Paper›PMID 26602301›Full record

Trial reportClinical infectious diseases : an official publication of the Infectious Diseases Society of America2015

The Potential Role of Mycotoxins as a Contributor to Stunting in the SHINE Trial.

Laura E Smith, Andrew J Prendergast, Paul C Turner, Mduduzi N N Mbuya, Kuda Mutasa, George Kembo, Rebecca J Stoltzfus, Sanitation Hygiene Infant Nutrition Efficacy (SHINE) Trial Team

Open access · hybridAbstract readClinical Trial
In one paragraph

Trial report in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 2 pooled it
8.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 66 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Occurrence and Co-Occurrence of Regulated and Emerging Mycotoxins in Foods Marketed to U.S. Toddlers.International journal of environmental research and public health · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Laura E SmithDivision of Nutritional Sciences, Cornell University, Ithaca, New York.
Andrew J PrendergastBlizard Institute, Queen Mary University of London, United Kingdom Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.
Paul C TurnerMaryland Institute for Applied Environmental Health, School of Public Health, University of Maryland, College Park.
Mduduzi N N MbuyaDivision of Nutritional Sciences, Cornell University, Ithaca, New York Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.
Kuda MutasaZvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.
George KemboFood and Nutrition Council, Harare, Zimbabwe.
Rebecca J StoltzfusDivision of Nutritional Sciences, Cornell University, Ithaca, New York.
Sanitation Hygiene Infant Nutrition Efficacy (SHINE) Trial Team
Zvitambo Institute for Maternal and Child Health Research · ZWCornell University · USUniversity of Maryland, College Park · US

Funding

Effect of a sanitation & nutrition intervention on HIV-exposed infant healthR01HD060338 · NICHD · JOHNS HOPKINS UNIVERSITY · PI HUMPHREY, JEAN HAWES · 2008 to 2012
$2.0M
Mycotoxin Exposure in Pregnancy and Birth Outcomes in ZimbabweR21ES023980 · NIEHS · CORNELL UNIVERSITY · PI STOLTZFUS, REBECCA J · 2015 to 2016
$419k
NICHD NIH HHS 2R01HD060338-06NICHD NIH HHS R01 HD060338NIEHS NIH HHS 1R21 ES023980-01A1NIEHS NIH HHS R21 ES023980Wellcome Trust 093768/Z/10/ZWellcome Trust 100714
6 · The paper itself

Abstract

Children in developing countries experience multiple exposures that are harmful to their growth and development. An emerging concern is frequent exposure to mycotoxins that contaminate a wide range of staple foods, including maize and groundnuts. Three mycotoxins are suspected to contribute to poor child health and development: aflatoxin, fumonisin, and deoxynivalenol. We summarize the evidence that mycotoxin exposure is associated with stunting, and propose that the causal pathway may be through environmental enteric dysfunction (EED) and disturbance of the insulin-like growth factor 1 (IGF-1) axis. The objectives of this substudy are to assess the relationship between agricultural and harvest practices and mycotoxin exposure; to evaluate associations between mycotoxin exposure and child stunting; and to investigate EED as a potential pathway linking mycotoxin exposure to child stunting, to inform potential areas for intervention.

Indexed as

EatingFemaleFood ContaminationGrowth DisordersHumansInfantMaleMycotoxinsResearch DesignRural PopulationZimbabweMycotoxinsaflatoxindeoxynivalenolfumonisinmycotoxinstunting

Identifiers

PMID26602301
PMCPMC4657594
OpenAlexW2174928960

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.