ArticleScientific reports2015
Attenuation of Histone Methyltransferase KRYPTONITE-mediated transcriptional gene silencing by Geminivirus.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 38 citations in OpenAlex.
- In Silico Investigation of the Interactions Between Cotton Leaf Curl Multan Virus Proteins and the Transcriptional Gene Silencing Factors of Gossypium hirsutum L.Journal of molecular evolution · 2024Article
- Review
- The identification of the methylation patterns of tomato curly stunt virus in resistant and susceptible tomato lines.Frontiers in plant science · 2023Article
- Influence of virus-host interactions on plant response to abiotic stress.Plant cell reports · 2021Review
- Plant responses to geminivirus infection: guardians of the plant immunity.Virology journal · 2021Review
- Geminiviral Triggers and Suppressors of Plant Antiviral Immunity.Microorganisms · 2021Review
- Targets and Mechanisms of Geminivirus Silencing Suppressor Protein AC2.Frontiers in microbiology · 2021Review
- Geminivirus-Encoded Proteins: Not All Positional Homologs Are Made Equal.Frontiers in microbiology · 2020Article
- Antagonistic Actions of FPA and IBM2 Regulate Transcript Processing from Genes Containing Heterochromatin.Plant physiology · 2019Article
- Analysis of Rice Proteins with DLN Repressor Motif/S.International journal of molecular sciences · 2019Article
- Geminiviral V2 Protein Suppresses Transcriptional Gene Silencing through Interaction with AGO4.Journal of virology · 2019Article
- Tomato Yellow Leaf Curl Virus V2 Interacts with Host Histone Deacetylase 6 To Suppress Methylation-Mediated Transcriptional Gene Silencing in Plants.Journal of virology · 2018Article
- A novel miRNA analysis framework to analyze differential biological networks.Scientific reports · 2017Article
- Differential response of cassava genotypes to infection by cassava mosaic geminiviruses.Virus research · 2017Article
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although histone H3K9 methylation has been intensively studied in animals and a model plant Arabidopsis thaliana, little is known about the evolution of the histone methyltransferase and its roles in plant biotic stress response. Here we identified a Nicotiana benthamiana homolog of H3K9 histone methyltransferase KRYPTONITE (NbKYP) and demonstrated its fundamental roles on methylation of plant and virus, beside of leading to the suppression of endogenous gene expression and virus replication. NbKYP and another gene encoding DNA methyltransferase CHROMOMETHYLTRANSFERASE 3 (NbCMT3-1) were further identified as the key components of maintenance of transcriptional gene silencing, a DNA methylation involved anti-virus machinery. All three types of DNA methylations (asymmetric CHH and symmetric CHG/CG) were severely affected in NbKYP-silenced plants, but only severe reduction of CHG methylation found in NbCMT3-1-silenced plants. Attesting to the importance of plant histone H3K9 methylation immunity to virus, the virulence of geminiviruses requires virus-encoded trans-activator AC2 which inhibits the expression of KYP via activation of an EAR-motif-containing transcription repressor RAV2 (RELATED TO ABI3 and VP1). The reduction of KYP was correlated with virulence of various similar geminiviruses. These findings provide a novel mechanism of how virus trans-activates a plant endogenous anti-silencing machinery to gain high virulence.
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