ArticleGenetics, selection, evolution : GSE2015
Genome-wide linkage disequilibrium and genetic diversity in five populations of Australian domestic sheep.
Article in Genetics, selection, evolution : GSE, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed.
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- Artificial and natural selection components reveal the mechanisms of tropical sheep populations against gastrointestinal parasites.PloS one · 2026Article
- Study of Genetic Progress in the Context of Disconnection Between Two Originally Connected Populations.Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie · 2026Article
- Genomic Diversity of U.S. Katahdin Hair Sheep.Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie · 2025Article
- Genomic diversity and population structure analysis of four geographically distinct Holstein cattle populations using genome-wide DNA profiling.Archives animal breeding · 2025Article
- Genetic diversity in German Pomeranian Coarsewool sheep and the possibility of breeding for maedi-visna resistance.Archives animal breeding · 2025Article
- Genomic insights into runs of homozygosity, effective population size and selection signatures in Iranian meat and dairy sheep breeds.PloS one · 2025Article
- Chromosome-Level Genome Assembly ofInternational journal of molecular sciences · 2024Article
- Article
- Detection of selective sweep in European wild sheep breeds.3 Biotech · 2024Article
- Genomic Characterization and Initial Insight into Mastitis-Associated SNP Profiles of Local LatvianAnimals : an open access journal from MDPI · 2023Article
- Genome-wide assessment of the population structure and genetic diversity of four Portuguese native sheep breeds.Frontiers in genetics · 2023Article
- Genome-wide study of linkage disequilibrium, population structure, and inbreeding in Iranian indigenous sheep breeds.PloS one · 2023Article
- High-density SNP markers elucidate the genetic divergence and population structure of Noticiana sheep breed in the Mediterranean context.Frontiers in veterinary science · 2023Article
- Population structure, genetic diversity and prolificacy in pishan red sheep under an extreme desert environment.Frontiers in genetics · 2023Article
- Genomic analysis of 10 years of artificial selection in community-based breeding programs in two Ethiopian indigenous sheep breeds.Animal genetics · 2022Article
- Capturing Genetic Diversity and Selection Signatures of the Endangered Kosovar Balusha Sheep Breed.Genes · 2022Article
- The genomic structure of isolation across breed, country and strain for important South African and Australian sheep populations.BMC genomics · 2022Article
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4 authors.
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Abstract
backgroundKnowledge of the genetic structure and overall diversity of livestock species is important to maximise the potential of genome-wide association studies and genomic prediction. Commonly used measures such as linkage disequilibrium (LD), effective population size (N e ), heterozygosity, fixation index (F ST) and runs of homozygosity (ROH) are widely used and help to improve our knowledge about genetic diversity in animal populations. The development of high-density single nucleotide polymorphism (SNP) arrays and the subsequent genotyping of large numbers of animals have greatly increased the accuracy of these population-based estimates.
methodsIn this study, we used the Illumina OvineSNP50 BeadChip array to estimate and compare LD (measured by r (2) and D'), N e , heterozygosity, F ST and ROH in five Australian sheep populations: three pure breeds, i.e., Merino (MER), Border Leicester (BL), Poll Dorset (PD) and two crossbred populations i.e. F1 crosses of Merino and Border Leicester (MxB) and MxB crossed to Poll Dorset (MxBxP).
resultsCompared to other livestock species, the sheep populations that were analysed in this study had low levels of LD and high levels of genetic diversity. The rate of LD decay was greater in Merino than in the other pure breeds. Over short distances (<10 kb), the levels of LD were higher in BL and PD than in MER. Similarly, BL and PD had comparatively smaller N e than MER. Observed heterozygosity in the pure breeds ranged from 0.3 in BL to 0.38 in MER. Genetic distances between breeds were modest compared to other livestock species (highest F ST = 0.063) but the genetic diversity within breeds was high. Based on ROH, two chromosomal regions showed evidence of strong recent selection.
conclusionsThis study shows that there is a large range of genome diversity in Australian sheep breeds, especially in Merino sheep. The observed range of diversity will influence the design of genome-wide association studies and the results that can be obtained from them. This knowledge will also be useful to design reference populations for genomic prediction of breeding values in sheep.
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