ArticleScientific reports2015
A new animal model of placebo analgesia: involvement of the dopaminergic system in reward learning.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 36 citations in OpenAlex.
- Direct comparisons of neural activity during placebo analgesia and nocebo hyperalgesia between humans and rats.Communications biology · 2025Article
- Convergent state-control of endogenous opioid analgesia.bioRxiv : the preprint server for biology · 2025Article
- Haloperidol for Pain Management: A Narrative Review.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Using Drift Diffusion and RL Models to Disentangle Effects of Depression On Decision-Making vs. Learning in the Probabilistic Reward Task.Computational psychiatry (Cambridge, Mass.) · 2024Article
- How Instructions, Learning, and Expectations Shape Pain and Neurobiological Responses.Annual review of neuroscience · 2023Review
- Placebo: a brief updated review.Naunyn-Schmiedeberg's archives of pharmacology · 2022Review
- Psycho-Neuro-Endocrine-Immunological Basis of the Placebo Effect: Potential Applications beyond Pain Therapy.International journal of molecular sciences · 2022Review
- Engaging endogenous opioid circuits in pain affective processes.Journal of neuroscience research · 2022Review
- Current Tracking on Effectiveness and Mechanisms of Acupuncture Therapy: A Literature Review of High-Quality Studies.Chinese journal of integrative medicine · 2020Review
- Failure of Placebo Analgesia Model in Rats with Inflammatory Pain.Neuroscience bulletin · 2020Article
- Sensory neuropathy and nociception in rodent models of Parkinson's disease.Disease models & mechanisms · 2019Review
- The Placebo Effect in Pain Therapies.Annual review of pharmacology and toxicology · 2019Review
- Role of placebo effects in pain and neuropsychiatric disorders.Progress in neuro-psychopharmacology & biological psychiatry · 2018Review
- A Context-Based Analgesia Model in Rats: Involvement of Prefrontal Cortex.Neuroscience bulletin · 2018Article
- The Intricate Influence of the Placebo Effect on Medical Cannabis and Cannabinoids.Medical cannabis and cannabinoids · 2018Article
- Placebo Analgesia in Rodents: Current and Future Research.International review of neurobiology · 2018Review
- Network analysis of the genomic basis of the placebo effect.JCI insight · 2017Article
- Long-term Treatment Benefits and Prolonged Efficacy of OnabotulinumtoxinA in Patients Affected by Chronic Migraine and Medication Overuse Headache over 3 Years of Therapy.Frontiers in neurology · 2017Article
- Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We suggest a new placebo analgesia animal model and investigated the role of the dopamine and opioid systems in placebo analgesia. Before and after the conditioning, we conducted a conditioned place preference (CPP) test to measure preferences for the cues (Rooms 1 and 2), and a hot plate test (HPT) to measure the pain responses to high level-pain after the cues. In addition, we quantified the expression of tyrosine hydroxylase (TH) in the ventral tegmental area (VTA) and c-Fos in the anterior cingulate cortex (ACC) as a response to reward learning and pain response. We found an enhanced preference for the low level-pain paired cue and enhanced TH expression in the VTA of the Placebo and Placebo + Naloxone groups. Haloperidol, a dopamine antagonist, blocked these effects in the Placebo + Haloperidol group. An increased pain threshold to high-heat pain and reduced c-Fos expression in the ACC were observed in the Placebo group only. Haloperidol blocked the place preference effect, and naloxone and haloperidol blocked the placebo analgesia. Cue preference is mediated by reward learning via the dopamine system, whereas the expression of placebo analgesia is mediated by the dopamine and opioid systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.