ArticleScientific reports2015
Genetic adaptations of the plateau zokor in high-elevation burrows.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Variants ofLife science alliance · 2026Article
- Gene Ontology-Based Comparative Transcriptomics Provides Evidence of Genetic Adaptations in theAnimals : an open access journal from MDPI · 2026Article
- Low temperature rather than hypoxia drives cholesterol synthesis and oxygen consumption in plateau zokors.iScience · 2026Article
- Study on Gut Microbiota Adaptation of Plateau Zokor (Microorganisms · 2026Article
- Synchronized Expansion and Contraction of Olfactory, Vomeronasal, and Taste Receptor Gene Families in Hystricomorph Rodents.Molecular biology and evolution · 2024Article
- Mosaic environment-driven evolution of the deep-sea mussel Gigantidas platifrons bacterial endosymbiont.Microbiome · 2023Article
- Molecular mechanisms of adaptive evolution in wild animals and plants.Science China. Life sciences · 2023Review
- Gut microbiota facilitates adaptation of the plateau zokor (Frontiers in microbiology · 2023Article
- Novel genotypes ofInternational journal for parasitology. Parasites and wildlife · 2022Article
- Functional genomics analysis reveals the evolutionary adaptation and demographic history of pygmy lorises.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- The Complex and Well-Developed Morphological and Histological Structures of the Gastrointestinal Tract of the Plateau Zokor Improve Its Digestive Adaptability to High-Fiber Foods.Animals : an open access journal from MDPI · 2022Article
- Vitamin DAnimals : an open access journal from MDPI · 2022Article
- Long-Read Genome Sequencing Provides Molecular Insights into Scavenging and Societal Complexity in Spotted Hyena Crocuta crocuta.Molecular biology and evolution · 2022Article
- Gene losses may contribute to subterranean adaptations in naked mole-rat and blind mole-rat.BMC biology · 2022Article
- A New Homotetramer Hemoglobin in the Pulmonary Surfactant of Plateau Zokors (Frontiers in genetics · 2022Article
- Response to Different Oxygen Partial Pressures and Evolution Analysis of Apoptosis-Related Genes in Plateau Zokor (Frontiers in genetics · 2022Article
- Chromosome-Level Reference Genome Assembly for the American Pika (Ochotona princeps).The Journal of heredity · 2021Article
- Searching for signatures of positive selection in cytochrome b gene associated with subterranean lifestyle in fast-evolving arvicolines (Arvicolinae, Cricetidae, Rodentia).BMC ecology and evolution · 2021Article
- Adaptive convergence at the genomic level-prevalent, uncommon or very rare?National science review · 2020Article
- Genome of the webworm Hyphantria cunea unveils genetic adaptations supporting its rapid invasion and spread.BMC genomics · 2020Article
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Authors and funding
7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The plateau zokor (Myospalax baileyi) spends its entire life underground in sealed burrows. Confronting limited oxygen and high carbon dioxide concentrations, and complete darkness, they epitomize a successful physiological adaptation. Here, we employ transcriptome sequencing to explore the genetic underpinnings of their adaptations to this unique habitat. Compared to Rattus norvegicus, genes belonging to GO categories related to energy metabolism (e.g. mitochondrion and fatty acid beta-oxidation) underwent accelerated evolution in the plateau zokor. Furthermore, the numbers of positively selected genes were significantly enriched in the gene categories involved in ATPase activity, blood vessel development and respiratory gaseous exchange, functional categories that are relevant to adaptation to high altitudes. Among the 787 genes with evidence of parallel evolution, and thus identified as candidate genes, several GO categories (e.g. response to hypoxia, oxygen homeostasis and erythrocyte homeostasis) are significantly enriched, are two genes, EPAS1 and AJUBA, involved in the response to hypoxia, where the parallel evolved sites are at positions that are highly conserved in sequence alignments from multiple species. Thus, accelerated evolution of GO categories, positive selection and parallel evolution at the molecular level provide evidences to parse the genetic adaptations of the plateau zokor for living in high-elevation burrows.
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