SynthesisInfluenza and other respiratory viruses2016
Impact of neuraminidase inhibitors on influenza A(H1N1)pdm09-related pneumonia: an individual participant data meta-analysis.
Open access · goldAbstract readMeta-Analysis
In one paragraph
Synthesis in Influenza and other respiratory viruses, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
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36citing papers in PubMed, 4 pooled it
4.1field-weighted citation impact, top 5% of its field
What it found
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The trial behind it
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Who cites it
36 citing papers in PubMed, 4 syntheses or guidelines pooled it, 73 citations in OpenAlex.
- Antivirals for treatment of severe influenza: a systematic review and network meta-analysis of randomised controlled trials.Lancet (London, England) · 2024Pooled it
- Systematic review of respiratory viral pathogens identified in adults with community-acquired pneumonia in Europe.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2017Pooled it
- Impact of neuraminidase inhibitors on influenza A(H1N1)pdm09-related pneumonia: an individual participant data meta-analysis.Influenza and other respiratory viruses · 2016Pooled it
- Pooled it
- Benefit of Early Oseltamivir Therapy for Adults Hospitalized With Influenza A: An Observational Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025Observational
- Timing of Influenza Antiviral Therapy and Risk of Death in Adults Hospitalized With Influenza-Associated Pneumonia, Influenza Hospitalization Surveillance Network (FluSurv-NET), 2012-2019.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025Article
- Polydopamine-based nanomedicines for efficient antiviral and secondary injury protection therapy.Science advances · 2023Article
- Influenza presentations and use of neuraminidase inhibitors by Australian general practice registrars: a cross-sectional analysis from the ReCEnT study.Family medicine and community health · 2023Article
- Point-of-Care Influenza Testing Impacts Clinical Decision, Patient Flow, and Length of Stay in Hospitalized Adults.The Journal of infectious diseases · 2022Observational
- Flu-IV score: a predictive tool for assessing the risk of invasive mechanical ventilation in patients with influenza-related pneumonia.BMC pulmonary medicine · 2022Article
- Clinical impact of nosocomial infection with pandemic influenza A (H1N1) 2009 in a respiratory ward in Guangzhou.Journal of thoracic disease · 2021Article
- The severity and risk factors for mortality in immunocompromised adult patients hospitalized with influenza-related pneumonia.Annals of clinical microbiology and antimicrobials · 2021Article
- Review
- The Chronic Kidney Disease in Africa (CKD-Africa) collaboration: lessons from a new pan-African network.BMJ global health · 2021Article
- Concentrated Secretome of Adipose Stromal Cells Limits Influenza A Virus-Induced Lung Injury in Mice.Cells · 2021Article
- Rationale for azithromycin in COVID-19: an overview of existing evidence.BMJ open respiratory research · 2021Review
- Complications of Cardiovascular Events in Patients Hospitalized with Influenza-Related Pneumonia.Infection and drug resistance · 2021Article
- Early oseltamivir treatment improves survival in critically ill patients with influenza pneumonia.ERJ open research · 2021Article
- Invasive pulmonary aspergillosis in immunocompetent patients hospitalised with influenza A-related pneumonia: a multicenter retrospective study.BMC pulmonary medicine · 2020Article
- The impact of early neuraminidase inhibitor therapy on clinical outcomes in patients hospitalised with influenza A-related pneumonia: a multicenter, retrospective study.BMC infectious diseases · 2020Article
Corrections and comments
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Authors and funding
85 authors at 20 institutions in 39 countries.
Stella G MuthuriDivision of Epidemiology and Public Health, University of Nottingham, Nottingham, UK.
Sudhir VenkatesanDivision of Epidemiology and Public Health, University of Nottingham, Nottingham, UK.
Puja R MylesDivision of Epidemiology and Public Health, University of Nottingham, Nottingham, UK.
Jo Leonardi-BeeDivision of Epidemiology and Public Health, University of Nottingham, Nottingham, UK.
Wei Shen LimRespiratory Medicine, Nottingham University Hospitals NHS Trust, Nottingham, UK.
Abdullah Al MamunInternational Centre for Diarrhoeal Diseases, Research Bangladesh (ICDDRB), Dhaka, Bangladesh.
Ashish P AnovadiyaDepartment of Pharmacology, Government Medical College and Sir Takhtsinhji General Hospital, Bhavnagar, Gujarat, India.
Wildo N AraújoUniversity of Brasília, Brasília, DF, Brazil.
Eduardo Azziz-BaumgartnerCenters for Disease Control and Prevention, Atlanta, GA, USA.
Clarisa BáezMinisterio de Salud de la Provincia de Buenos Aires, Buenos Aires, Argentina.
Carlos BantarDepartment of Infection Control, Hospital San Martín de Paraná, Entre Ríos, Argentina.
Mazen M BarhoushDepartment of Medicine, King Saud Medical City, Riyadh, Saudi Arabia.
Matteo BassettiSanta Maria Misericordia Hospital, Udine, Italy.
Bojana BeovicDepartment of Infectious Diseases, University Medical Centre, Ljubljana, Slovenia.
Roland BingisserDepartment of Emergency Medicine, University Hospital Basel, Basel, Switzerland.
Isabelle BonmarinInstitut de Veille Sanitaire, Saint-Maurice, France.
Victor H Borja-AburtoInstituto Mexicano del Seguro Social (IMSS), Mexico City, Mexico.
Bin CaoBeijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Jordi CarratalaDepartment of Infectious Diseases, Hospital Universitari de Bellvitge, Bellvitge Institute for Biomedical Research, L'Hospitalet de Llobregat, Red Española de Investigación en Patología Infecciosa, University of Barcelona, Barcelona, Spain.
María R CuezzoMinisterio de Salud de Tucumán, Tucumán, Argentina.
Justin T DenholmVictorian Infectious Diseases Service and Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, Parkville, Vic., Australia.
Samuel R DominguezDepartment of Pediatric Infectious Diseases, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, CO, USA.
Pericles A D DuarteUniversidade Estadual do Oeste do Paraná, UNIOESTE, Cascavel, PR, Brazil.
Gal Dubnov-RazThe Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel-Hashomer, Israel.
Marcela EchavarriaClinical Virology Laboratory, CEMIC University Hospital, Buenos Aires, Argentina.
Sergio FanellaSection of Pediatric Infectious Diseases, University of Manitoba, Winnipeg, MB, Canada.
James FraserPaediatric Intensive Care Unit, Bristol Children's Hospital, Bristol, UK.
Zhancheng GaoDepartment of Respiratory & Critical Care Medicine, Peking University People's Hospital, Beijing, China.
Patrick GérardinNICU/PICU, PFME, CHU Saint Pierre, Saint Pierre, La Réunion, France.
Maddalena GiannellaDepartment of Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
Sophie GubbelsDepartment of Infectious Disease Epidemiology, Sector for National Health Documentation and Research, Statens Serum Institut, Copenhagen, Denmark.
Jethro HerbergSection of Paediatrics, Division of Infectious Disease, Imperial College, London, UK.
Anjarath L Higuera IglesiasEpidemiology Research Unit, Instituto Nacional de Enfermedades Respiratorias, Ismael Cosío Villegas, Mexico City, Mexico.
Peter H HoegerCath. Children's Hospital Wilhelmstift, Hamburg, Germany.
Matthias HoffmannDivision of Infectious Diseases and Hospital Epidemiology, Kantonsspital St. Gallen, St. Gallen, Switzerland.
Xiaoyun HuPeking Union Medical College Hospital, Beijing, China.
Quazi T IslamDhaka Medical College Hospital, Dhaka, Bangladesh.
Mirela F JiménezDepartamento de Ginecologia e Obstetrícia - UFCSPA, Preceptora da Residência Médica do Hospital Fêmina, Porto Alegre, Brazil.
Amr KandeelMinistry of Health in Egypt, Cairo, Egypt.
Gerben KeijzersGold Coast Hospital, Gold Coast, Qld, Australia.
Hossein KhaliliDepartment of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Gulam KhandakerNational Centre for Immunisation Research and Surveillance (NCIRS), The Children's Hospital at Westmead, University of Sydney, Sydney, NSW, Australia.
Marian KnightNational Perinatal Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Gabriela KusznierzNational Institute of Respiratory Diseases 'Emilio Coni' ANLIS "C. Malbran", Santa Fe, Argentina.
Ilija KuzmanSchool of Medicine, University Hospital for Infectious Diseases, University of Zagreb, Zagreb, Croatia.
Arthur M C KwanDepartment of Intensive Care, Pamela Youde Nethersole Eastern Hospital, Chai Wan, Hong Kong.
Idriss Lahlou AmineFaculty of Medicine and Pharmacy, Mohammed V Military Teaching Hospital, Biosafety Level 3 and Research Laboratory, University Mohammed V-Souissi, Rabat, Morocco.
Eduard LangeneggerDepartment of Obstetrics and Gynaecology, Stellenbosch University and Tygerberg, Stellenbosch, South Africa.
Kamran B LankaraniHealth Policy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Yee-Sin LeoDepartment of Infectious Diseases, Tan Tock Seng Hospital, Singapore, Singapore.
Rita LinkoHelsinki University Hospital, Helsinki, Finland.
Pei LiuDepartment of Infectious Diseases, The First Affiliated Hospital, China Medical University, Shenyang, China.
Faris MadanatDepartment of Pediatrics, King Hussein Cancer Center, Amman, Jordan.
Toshie ManabeGraduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Elga Mayo-MonteroInstituto de Medicina Preventiva de la Defensa, Capitan Medico Ramon y Cajal (IMPDEF), Ministerio de Defensa, Madrid, Spain.
Allison McGeerToronto Invasive Bacterial Diseases Network, University of Toronto, Toronto, ON, Canada.
Ziad A MemishMinistry of Health, Riyadh, Saudi Arabia.
Gokhan MetanDepartment of Infectious Diseases and Clinical Microbiology, Erciyes University Faculty of Medicine, Kayseri, Turkey.
Dragan MikićMilitary Medical Academy, Clinic for Infectious and Tropical Diseases, Belgrade, Serbia.
Kristin G I MohnSection for Infectious Diseases, Medical Department, and Department of Research and Development, Haukeland University Hospital, Bergen, Norway.
Ahmadreza MoradiThe Division of Ocular Immunology, Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Pagbajabyn NymadawaNational Influenza Center, National Center of Communicable Diseases, Ministry of Health, Ulaanbaatar, Mongolia.
Bulent OzbayDepartment of Pulmonary and Critical Care, Yuzuncu Yil University Medical Faculty, Van, Turkey.
Mehpare OzkanClinic of Pediatric Neurology, Dr. Sami Ulus Research and Training Hospital of Women's and Children's Health and Diseases, Ankara, Turkey.
Dhruv ParekhCritical Care and Pain Perioperative, Critical Care and Trauma Trials Group, School of Clinical and Experimental Medicine, University of Birmingham, Birmingham, UK.
Mical PaulDivision of Infectious Diseases, Rambam Health Care Campus, Haifa, Israel.
Wolfgang PoepplMedical University of Vienna, Vienna, Austria.
Fernando P PolackDepartment of Pediatrics, Vanderbilt Vaccine Center, Vanderbilt University, Nashville, TN, USA.
Barbara A RathDivision of Pneumonology-Immunology, Department of Pediatrics, Charité University Medical Center, Berlin, Germany.
Alejandro H RodríguezCritical Care Department, Hospital Joan XXIII, IISPV, URV, CIBERES, Tarragona, Spain.
Marilda M SiqueiraLaboratory of Respiratory Viruses, Oswaldo Cruz Institute/Fiocruz, Rio de Janeiro, Brazil.
Joanna Skręt-MagierłoUniwersytet Rzeszowski, Rzeszów, Poland.
Ewa TalarekDepartment of Children's Infectious Diseases, Medical University of Warsaw, Warsaw, Poland.
Julian W TangDivision of Microbiology/Molecular Diagnostic Centre, Department of Laboratory Medicine, National University Hospital, Singapore, Singapore.
Antoni TorresHospital Clinic, University of Barcelona, IDIBAPS, CIBERES, Barcelona, Spain.
Selda H TörünDepartment of Pediatric Infectious Diseases, Istanbul Medical Faculty, Istanbul, Turkey.
Dat TranDivision of Infectious Diseases, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Canada.
Timothy M UyekiInfluenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Annelies van ZwolDepartment of Pediatric Intensive Care, VU University Medical Center, Amsterdam, The Netherlands.
Wendy VaudryDivision of Infectious Diseases, Department of Pediatrics, Stollery Children's Hospital, University of Alberta, Edmonton, AB, Canada.
Daiva VelyvyteLithuanian University of Health Sciences, Kaunas, Lithuania.
Tjasa VidmarGeneral Hospital, Slovenj Gradec, Slovenia.
Paul ZarogoulidisUnit of Infectious Diseases, University General Hospital of Alexandroupolis, Democritus University Thrace, Dragana, Greece.
PRIDE Consortium Investigators
Jonathan S Nguyen-Van-TamDivision of Epidemiology and Public Health, University of Nottingham, Nottingham, UK.
University of Nottingham · GBUniversity of Toronto · CAAdministración Nacional de Laboratorios e Institutos de Salud · ARAmsterdam UMC Location VUmc · NLBristol Royal Hospital for Children · GBCapital Medical University · CNCenters for Disease Control and Prevention · USCentro de Educación Médica e Investigaciones Clínicas Norberto Quirno · ARCharité - Universitätsmedizin Berlin · DEChildren's Hospital Colorado · USChina Medical University · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNConsorci Institut D'Investigacions Biomediques August Pi I Sunyer · ESDemocritus University of Thrace · GRDhaka Medical College and Hospital · BDDr Sami Ulus Çocuk Sağlığı ve Hastalıkları Eğitim ve Araştırma Hastanesi · TRErciyes University · TRFundação Oswaldo Cruz · BRGold Coast Hospital · AUHaukeland University Hospital · NO
Funding
Department of Health 11/46/12Medical Research Council MR/J011266/1
Abstract
backgroundThe impact of neuraminidase inhibitors (NAIs) on influenza-related pneumonia (IRP) is not established. Our objective was to investigate the association between NAI treatment and IRP incidence and outcomes in patients hospitalised with A(H1N1)pdm09 virus infection.
methodsA worldwide meta-analysis of individual participant data from 20 634 hospitalised patients with laboratory-confirmed A(H1N1)pdm09 (n = 20 021) or clinically diagnosed (n = 613) 'pandemic influenza'. The primary outcome was radiologically confirmed IRP. Odds ratios (OR) were estimated using generalised linear mixed modelling, adjusting for NAI treatment propensity, antibiotics and corticosteroids.
resultsOf 20 634 included participants, 5978 (29·0%) had IRP; conversely, 3349 (16·2%) had confirmed the absence of radiographic pneumonia (the comparator). Early NAI treatment (within 2 days of symptom onset) versus no NAI was not significantly associated with IRP [adj. OR 0·83 (95% CI 0·64-1·06; P = 0·136)]. Among the 5978 patients with IRP, early NAI treatment versus none did not impact on mortality [adj. OR = 0·72 (0·44-1·17; P = 0·180)] or likelihood of requiring ventilatory support [adj. OR = 1·17 (0·71-1·92; P = 0·537)], but early treatment versus later significantly reduced mortality [adj. OR = 0·70 (0·55-0·88; P = 0·003)] and likelihood of requiring ventilatory support [adj. OR = 0·68 (0·54-0·85; P = 0·001)].
conclusionsEarly NAI treatment of patients hospitalised with A(H1N1)pdm09 virus infection versus no treatment did not reduce the likelihood of IRP. However, in patients who developed IRP, early NAI treatment versus later reduced the likelihood of mortality and needing ventilatory support.
Indexed as
Influenza A Virus, H1N1 SubtypeAdolescentAdrenal Cortex HormonesAdultAnti-Bacterial AgentsAntiviral AgentsChildChild, PreschoolEnzyme InhibitorsFemaleHumansInfluenza, HumanMaleMiddle AgedNeuraminidaseOdds RatioAdrenal Cortex HormonesAnti-Bacterial AgentsAntiviral AgentsEnzyme InhibitorsNeuraminidaseHospitalisationindividual participant data meta-analysesinfluenza-related pneumonianeuraminidase inhibitors
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