Evidence map›Paper›PMID 26601998›Full record

ArticleBrazilian journal of otorhinolaryngology

Evaluation of the improvement of quality of life with Azithromycin in the treatment of eosinophilic nasal polyposis.

Isamara Simas de Oliveira, Paulo Fernando Tormin Borges Crosara, Geovanni Dantas Cassali, Diego Carlos dos Reis, Camilo Brandão de Resende, Flavio Barbosa Nunes, Roberto Eustáquio Santos Guimarães

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brazilian journal of otorhinolaryngology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Heterogeneity in the definition of chronic rhinosinusitis disease control: a systematic review of the scientific literature.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2023
    Pooled it
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Isamara Simas de OliveiraDepartment of Surgery and Ophthalmology, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil. Electronic address: simasmed@gmail.com.
Paulo Fernando Tormin Borges CrosaraDepartment of Ophthalmology, Otorhinolaryngology and Phonoaudiology, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.
Geovanni Dantas CassaliDepartment of General Pathology, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.
Diego Carlos dos ReisMedicine School, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.
Camilo Brandão de ResendeInstituto Tecnológico de Aeronáutica, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.
Flavio Barbosa NunesDepartment of Ophthalmology, Otorhinolaryngology and Phonoaudiology, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.
Roberto Eustáquio Santos GuimarãesDepartment of Ophthalmology, Otorhinolaryngology and Phonoaudiology, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.
Universidade Federal de Minas Gerais · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe Sino-Nasal Outcome Test 22 (SNOT-22) is an important tool in assessing the quality of life (QoL) of patients with chronic rhinosinusitis with a validated version in Brazil. The eosinophilic nasal polyposis (ENP) represents most of the cases of nasal polyposis (85-90%) and belongs to the group of chronic rhinosinusitis. It is a chronic inflammatory disease that impacts the QoL of patients, not only causing localized symptoms, but also resulting in a general malaise. The standard treatments (corticosteroids and nasal endoscopic surgery) lead to partial control of symptoms, but relapses are frequent. Macrolide acting as an immunomodulator is a promising tool for more effective control of this disease. Studies are still lacking to assess the real impact on the QoL in patients treated with macrolides.

objectiveTo evaluate the improvement of QL, evaluated using SNOT-22, in patients with PNSE treated with immunomodulatory dose azithromycin.

methodsThis is a paired experimental study in patients with ENP. Comparison of pre-treatment and post-treatment with azithromycin was performed. Patients completed the SNOT-22 questionnaire before the start of treatment and returned for evaluation after eight weeks of treatment. Azithromycin was prescribed at a dose of 500 mg, orally, three times a week, for 8 weeks.

resultsSNOT-22 score decreased 20.3 points on average. There was a significant decrease in the SNOT-22 (difference greater than 14 points) in 19 patients (57.6%). There was no significant difference in improvement in SNOT in subgroups with or without asthma/aspirin intolerance.

conclusionAzithromycin resulted in significant improvement of QoL, assessed by SNOT-22, in the studied population.

Indexed as

AdolescentAdultAnti-Bacterial AgentsAzithromycinChronic DiseaseFemaleHumansMaleMiddle AgedNasal PolypsQuality of LifeSurveys and QuestionnairesTreatment OutcomeYoung AdultAnti-Bacterial AgentsAzithromycinAzithromycinAzitromicinaEosinophilic nasal polyposisPolipose nasal eosinofílicaSNOT-22

Identifiers

PMID26601998
PMCPMC9449081
OpenAlexW1550974629

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.