Evidence map›Paper›PMID 26601826›Full record

ArticleGut and liver2016

Ascitic Fluid Calprotectin and Serum Procalcitonin as Accurate Diagnostic Markers for Spontaneous Bacterial Peritonitis.

Ahmed Abdel-Razik, Nasser Mousa, Dina Elhammady, Rania Elhelaly, Rasha Elzehery, Sherif Elbaz, Mohamed Eissa, Niveen El-Wakeel, Waleed Eldars

Open access · diamondAbstract readEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut and liver, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 2 pooled it
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 71 citations in OpenAlex.

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  14. Guidelines for the Use of Procalcitonin for Rational Use of Antibiotics.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Ahmed Abdel-RazikDepartment of Tropical Medicine, Mansoura University, Mansoura, Egypt.
Nasser MousaDepartment of Tropical Medicine, Mansoura University, Mansoura, Egypt.
Dina ElhammadyDepartment of Tropical Medicine, Mansoura University, Mansoura, Egypt.
Rania ElhelalyDepartment of Clinical Pathology, Mansoura University, Mansoura, Egypt.
Rasha ElzeheryDepartment of Clinical Pathology, Mansoura University, Mansoura, Egypt.
Sherif ElbazDepartment of Endemic Diseases and Gastroenterology, Aswan University, Aswan, Egypt.
Mohamed EissaDepartment of Internal Medicine, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Niveen El-WakeelDepartment of Medical Microbiology and Immunology, Mansoura University, Mansoura, Egypt.
Waleed EldarsDepartment of Medical Microbiology and Immunology, Mansoura University, Mansoura, Egypt.
Mansoura University · EGAswan University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimsThe diagnosis of spontaneous bacterial peritonitis (SBP) is based on a polymorphonuclear leukocytes (PMNs) exceeding 250/μL in ascitic fluid. The aim of the study was to evaluate serum procalcitonin and ascitic fluid calprotectin as accurate diagnostic markers for detecting SBP.

methodsSeventy-nine patients with cirrhotic ascites were included. They were divided into a SBP group, including 52 patients, and a non-SBP group of 27 patients. Serum procalcitonin, ascitic calprotectin, and serum and ascitic levels of tumor necrosis factor α (TNF-α) and interleukin 6 (IL- 6) were measured using an enzyme-linked immunosorbent assay.

resultsSerum procalcitonin and ascitic calprotectin were significantly higher in SBP patients than in non-SBP patients. Significant increases in both serum and ascitic levels of TNF-α and IL-6 were observed in SBP patients versus non- SBP patients. At a cutoff value of 0.94 ng/mL, serum procalcitonin had 94.3% sensitivity and 91.8% specificity for detecting SBP. In addition, at a cutoff value of 445 ng/mL, ascitic calprotectin had 95.4% sensitivity and 85.2% specificity for detecting SBP. Both were positively correlated with ascitic fluid proteins, PMN count, TNF-α, and IL-6.

conclusionsAccording to our findings, determination of serum procalcitonin levels and ascitic calprotectin appears to provide satisfactory diagnostic markers for the diagnosis of SBP.

Indexed as

AgedAscitic FluidBacterial InfectionsBiomarkersCalcitoninEnzyme-Linked Immunosorbent AssayFemaleHumansInterleukin-6Leukocyte L1 Antigen ComplexLiver CirrhosisMaleMiddle AgedPeritonitisReference ValuesSensitivity and SpecificityBiomarkersCalcitoninIL6 protein, humanInterleukin-6Leukocyte L1 Antigen ComplexTumor Necrosis Factor-alphaCalprotectinInterleukin-6ProcalcitoninSpontaneous bacterial peritonitisTumor necrosis factor-alpha

Identifiers

PMID26601826
PMCPMC4933425
OpenAlexW2409047332

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.