ArticleScience advances2015
Detection of single amino acid mutation in human breast cancer by disordered plasmonic self-similar chain.
Article in Science advances, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 75 citations in OpenAlex.
- Modulation of Circulating MicroRNAs Levels during the Switch from Clopidogrel to Ticagrelor.BioMed research international · 2016Trial
- Triple-Action Therapy: Combining Machine Learning, Docking, and Dynamics to Combat BRCA1-Mutated Breast Cancer.Molecular biotechnology · 2025Article
- Article
- Label-free plasmonic spectral profiling of serum DNA.Biosensors & bioelectronics · 2024Article
- An Opinion on How Nanobiotechnology is Assisting Humankind to Overcome the Coronavirus Disease 2019.Frontiers in bioengineering and biotechnology · 2022Article
- Correlative nanophotonic approaches to enlighten the nanoscale dynamics of living cell membranes.Biochemical Society transactions · 2021Review
- DNA Studies: Latest Spectroscopic and Structural Approaches.Micromachines · 2021Review
- A droplet reactor on a super-hydrophobic surface allows control and characterization of amyloid fibril growth.Communications biology · 2020Article
- Emerging Designs of Electronic Devices in Biomedicine.Micromachines · 2020Review
- Article
- Plasmonic Nanowires for Wide Wavelength Range Molecular Sensing.Materials (Basel, Switzerland) · 2018Article
- Two sides of the same coin? Unraveling subtle differences between human embryonic and induced pluripotent stem cells by Raman spectroscopy.Stem cell research & therapy · 2017Article
- Effect of Surface Plasmon Coupling to Optical Cavity Modes on the Field Enhancement and Spectral Response of Dimer-Based sensors.Scientific reports · 2017Article
- Scalable, ultra-resistant structural colors based on network metamaterials.Light, science & applications · 2017Article
- Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Control of the architecture and electromagnetic behavior of nanostructures offers the possibility of designing and fabricating sensors that, owing to their intrinsic behavior, provide solutions to new problems in various fields. We show detection of peptides in multicomponent mixtures derived from human samples for early diagnosis of breast cancer. The architecture of sensors is based on a matrix array where pixels constitute a plasmonic device showing a strong electric field enhancement localized in an area of a few square nanometers. The method allows detection of single point mutations in peptides composing the BRCA1 protein. The sensitivity demonstrated falls in the picomolar (10(-12) M) range. The success of this approach is a result of accurate design and fabrication control. The residual roughness introduced by fabrication was taken into account in optical modeling and was a further contributing factor in plasmon localization, increasing the sensitivity and selectivity of the sensors. This methodology developed for breast cancer detection can be considered a general strategy that is applicable to various pathologies and other chemical analytical cases where complex mixtures have to be resolved in their constitutive components.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.