ArticleScience advances2015
A dietary phytochemical alters caste-associated gene expression in honey bees.
Article in Science advances, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 98 citations in OpenAlex.
- Propolis as a Key Source ofInsects · 2025Article
- The Sublethal Effects of Neonicotinoids on Honeybees.Biology · 2025Review
- Advanced Research on Biological Properties-A Study on the Activity of theInternational journal of molecular sciences · 2025Article
- Food as Medicine: A Review of Plant Secondary Metabolites from Pollen, Nectar, and Resin with Health Benefits for Bees.Insects · 2025Review
- Sex-specific element accumulation in honey bees (Apis mellifera).Environmental science and pollution research international · 2025Article
- Annual Research Review: Micronutrients and their role in the treatment of paediatric mental illness.Journal of child psychology and psychiatry, and allied disciplines · 2025Review
- Omics in mini-livestock: a genomic perspective on the future of sustainable food systems.Frontiers in genetics · 2025Review
- Influence of Probiotics Feed Supplementation on Hypopharyngeal Glands Morphometric Measurements of Honeybee Workers Apis mellifera L.Probiotics and antimicrobial proteins · 2024Article
- Variation in Pesticide Toxicity in the Western Honey Bee (Apis mellifera) Associated with Consuming Phytochemically Different Monofloral Honeys.Journal of chemical ecology · 2024Article
- Oral administration of phytochemicals protects honey bees against cognitive and motor impairments induced by the insecticide fipronil.PloS one · 2024Article
- Phenotypic dimorphism between honeybee queen and worker is regulated by complicated epigenetic modifications.iScience · 2023Article
- Drosophila postembryonic nervous system development: a model for the endocrine control of development.Genetics · 2023Review
- Feeding Asian honeybee queens with European honeybee royal jelly alters body color and expression of related coding and non-coding RNAs.Frontiers in physiology · 2023Article
- Article
- Article
- Article
- Extent and complexity of RNA processing in honey bee queen and worker caste development.iScience · 2022Article
- The role of honey in the ecology of the hive: Nutrition, detoxification, longevity, and protection against hive pathogens.Frontiers in nutrition · 2022Review
- Article
- Specific phytochemicals in floral nectar up-regulate genes involved in longevity regulation and xenobiotic metabolism, extending mosquito life span.Ecology and evolution · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the eusocial honey bee Apis mellifera, with reproductive queens and sterile workers, a female larva's developmental fate depends on its diet; nurse bees feed queen-destined larvae exclusively royal jelly, a glandular secretion, but worker-destined larvae receive royal jelly for 3 days and subsequently jelly to which honey and beebread are added. RNA-Seq analysis demonstrated that p-coumaric acid, which is ubiquitous in honey and beebread, differentially regulates genes involved in caste determination. Rearing larvae in vitro on a royal jelly diet to which p-coumaric acid has been added produces adults with reduced ovary development. Thus, consuming royal jelly exclusively not only enriches the diet of queen-destined larvae but also may protect them from inhibitory effects of phytochemicals present in the honey and beebread fed to worker-destined larvae.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.