ArticleScience advances2015
Platform technology for scalable assembly of instantaneously functional mosaic tissues.
Article in Science advances, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- In vitro approaches to mimic cardiac mechanical load dynamics for enhancing maturation and disease modelling.Cardiovascular research · 2025Review
- Itaconate and citrate releasing polymer attenuates foreign body response in biofabricated cardiac patches.Materials today. Bio · 2024Article
- Elastomeric Polyesters in Cardiovascular Tissue Engineering and Organs-on-a-Chip.Biomacromolecules · 2023Review
- Leaf-venation-directed cellular alignment for macroscale cardiac constructs with tissue-like functionalities.Nature communications · 2023Article
- High Throughput Omnidirectional Printing of Tubular Microstructures from Elastomeric Polymers.Advanced healthcare materials · 2022Article
- Biofabricating murine and human myo-substitutes for rapid volumetric muscle loss restoration.EMBO molecular medicine · 2021Article
- Layer-By-Layer Fabrication of Thicker and Larger Human Cardiac Muscle Patches for Cardiac Repair in Mice.Frontiers in cardiovascular medicine · 2021Article
- Engineering Human Cardiac Muscle Patch Constructs for Prevention of Post-infarction LV Remodeling.Frontiers in cardiovascular medicine · 2021Review
- Elastic Biomaterial Scaffold with Spatially Varying Adhesive Design.Advanced biosystems · 2020Article
- Multidimensional assembly using layer-by-layer deposition for synchronized cardiac macro tissues.RSC advances · 2020Article
- Microfabrication of AngioChip, a biodegradable polymer scaffold with microfluidic vasculature.Nature protocols · 2018Article
- Can We Engineer a Human Cardiac Patch for Therapy?Circulation research · 2018Review
- Flexible shape-memory scaffold for minimally invasive delivery of functional tissues.Nature materials · 2017Article
- Poly(Limonene Thioether) Scaffold for Tissue Engineering.Advanced healthcare materials · 2016Article
- Strategies and Challenges to Myocardial Replacement Therapy.Stem cells translational medicine · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Engineering mature tissues requires a guided assembly of cells into organized three-dimensional (3D) structures with multiple cell types. Guidance is usually achieved by microtopographical scaffold cues or by cell-gel compaction. The assembly of individual units into functional 3D tissues is often time-consuming, relying on cell ingrowth and matrix remodeling, whereas disassembly requires an invasive method that includes either matrix dissolution or mechanical cutting. We invented Tissue-Velcro, a bio-scaffold with a microfabricated hook and loop system. The assembly of Tissue-Velcro preserved the guided cell alignment realized by the topographical features in the 2D scaffold mesh and allowed for the instant establishment of coculture conditions by spatially defined stacking of cardiac cell layers or through endothelial cell coating. The assembled cardiac 3D tissue constructs were immediately functional as measured by their ability to contract in response to electrical field stimulation. Facile, on-demand tissue disassembly was demonstrated while preserving the structure, physical integrity, and beating function of individual layers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.