ArticleScience advances2015
Structural basis for recognition of diverse transcriptional repressors by the TOPLESS family of corepressors.
Article in Science advances, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers.
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Who cites it
90 citing papers in PubMed, 180 citations in OpenAlex.
- Article
- β-Caryophyllene Competes With NINJA/IAAs for TOPLESS Family Corepressors to Regulate Plant Physiological Activities.Plant, cell & environment · 2026Article
- The TPR2 corepressor forms condensates with repressors to fine-tune growth and development in rice.The EMBO journal · 2026Article
- Triple florigenic signaling in rice promotes stem elongation via transcriptional de-repression.The Plant journal : for cell and molecular biology · 2026Article
- CONSERVATION AND DIVERGENCE WITHIN THEbioRxiv : the preprint server for biology · 2026Article
- Article
- SUPERMAN requires its EAR motif to recruit the corepressor TOPLESS and to function as a cadastral regulator in floral patterning.BMC plant biology · 2025Article
- Genome-Wide Identification, Drought-Responsive Expression, and EAR-Mediated Regulatory Network Construction ofPlants (Basel, Switzerland) · 2025Article
- An integrative multi-omics analysis of histone modifications and DNA methylation reveals the epigenomic landscape in apple under drought stress.Plant biotechnology journal · 2025Article
- Genome-Wide Identification ofGenes · 2025Article
- Transcriptional corepressor OsTPR1 regulates tillering and lateral root development in rice.Scientific reports · 2025Article
- TaHSP18.6 and TaSRT1 interact to confer resistance toProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Global identification and characterization of soybean TPR genes with expression analysis under photoperiod variations.Scientific reports · 2025Article
- RALF33-FERONIA signaling orchestrates postwounding root-tip regeneration via TPR4-ERF115 dynamics.The Plant cell · 2025Article
- OsbHLH062 regulates iron homeostasis by inhibiting iron deficiency responses in rice.aBIOTECH · 2025Article
- A TOPLESS-related gene regulates both male and female sterility in wheat.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Histone Modification-Dependent Transcriptional Regulation of Defence Genes in Early Response of Arabidopsis to Spodoptera litura Attack.Plant, cell & environment · 2025Article
- Structural insights into CDF1 accumulation on the CONSTANS promoter via a plant-specific DNA-binding domain.Nature plants · 2025Article
- The OsNL1-OsTOPLESS2-OsMOC1/3 pathway regulates high-order tiller outgrowth in rice.Plant biotechnology journal · 2025Article
- A function of TPL/TBL1-type corepressors is to nucleate the assembly of the preinitiation complex.The Journal of cell biology · 2025Article
30 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
TOPLESS (TPL) and TOPLESS-related (TPR) proteins comprise a conserved family of plant transcriptional corepressors that are related to Tup1, Groucho, and TLE (transducin-like enhancer of split) corepressors in yeast, insects, and mammals. In plants, TPL/TPR corepressors regulate development, stress responses, and hormone signaling through interaction with small ethylene response factor-associated amphiphilic repression (EAR) motifs found in diverse transcriptional repressors. How EAR motifs can interact with TPL/TPR proteins is unknown. We confirm the amino-terminal domain of the TPL family of corepressors, which we term TOPLESS domain (TPD), as the EAR motif-binding domain. To understand the structural basis of this interaction, we determined the crystal structures of the TPD of rice (Os) TPR2 in apo (apo protein) state and in complexes with the EAR motifs from Arabidopsis NINJA (novel interactor of JAZ), IAA1 (auxin-responsive protein 1), and IAA10, key transcriptional repressors involved in jasmonate and auxin signaling. The OsTPR2 TPD adopts a new fold of nine helices, followed by a zinc finger, which are arranged into a disc-like tetramer. The EAR motifs in the three different complexes adopt a similar extended conformation with the hydrophobic residues fitting into the same surface groove of each OsTPR2 monomer. Sequence alignments and structure-based mutagenesis indicate that this mode of corepressor binding is highly conserved in a large set of transcriptional repressors, thus providing a general mechanism for gene repression mediated by the TPL family of corepressors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.