ArticleScience advances2015
Adding up the odds-Nitric oxide signaling underlies the decision to flee and post-conflict depression of aggression.
Article in Science advances, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 27 citations in OpenAlex.
- In Silico Characterisation of theInternational journal of molecular sciences · 2023Article
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- Fight outcome briefly affects the reproductive fitness of male crickets.Scientific reports · 2018Article
- Serotonin Mediates Depression of Aggression After Acute and Chronic Social Defeat Stress in a Model Insect.Frontiers in behavioral neuroscience · 2018Article
- Chronic social defeat induces long-term behavioral depression of aggressive motivation in an invertebrate model system.PloS one · 2017Article
- Losing without Fighting - Simple Aversive Stimulation Induces Submissiveness Typical for Social Defeat via the Action of Nitric Oxide, but Only When Preceded by an Aggression Priming Stimulus.Frontiers in behavioral neuroscience · 2017Article
- Controlling the decision to fight or flee: the roles of biogenic amines and nitric oxide in the cricket.Current zoology · 2016Article
- El grillo è buon cantore: for Franz Huber on the occasion of his 90th birthday.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2016Article
- Releasing stimuli and aggression in crickets: octopamine promotes escalation and maintenance but not initiation.Frontiers in behavioral neuroscience · 2015Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fighting is dangerous, which is why animals choose to flee once the costs outweigh the benefits, but the mechanisms underlying this decision-making process are unknown. By manipulating aggressive signaling and applying nitrergic drugs, we show that the evolutionarily conserved neuromodulator nitric oxide (NO), which has a suppressing effect on aggression in mammals, can play a decisive role. We found that crickets, which exhibit spectacular fighting behavior, flee once the sum of their opponent's aversive actions accrued during fighting exceeds a critical amount. This effect of aversive experience is mediated by the NO signaling pathway. Rather than suppressing aggressive motivation, NO increases susceptibility to aversive stimuli and with it the likelihood to flee. NO's effect is manifested in losers by prolonged avoidance behavior, characteristic for social defeat in numerous species. Intriguingly, fighting experience also induces, via NO, a brief susceptible period to aversive stimuli in winners just after victory. Our findings thus reveal a key role for NO in the mechanism underlying the decision to flee and post-conflict depression in aggressive behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.