ArticleBioMed research international2015
Application of Mathematical Modeling for Simulation and Analysis of Hypoplastic Left Heart Syndrome (HLHS) in Pre- and Postsurgery Conditions.
Article in BioMed research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- The hemodynamic impact of congenital heart diseases during fetal-to-neonatal transition: an in-silico investigation.Pediatric research · 2026Article
- Distensibility of Deformable Aortic Replicas Assessed by an Integrated In-Vitro and In-Silico Approach.Bioengineering (Basel, Switzerland) · 2022Article
- Computational fluid dynamics investigation of the novel hybrid comprehensive stage II operation.JTCVS open · 2021Article
- Numerical Models Can Assist Choice of an Aortic Phantom for In Vitro Testing.Bioengineering (Basel, Switzerland) · 2021Article
- A review on low-dimensional physics-based models of systemic arteries: application to estimation of central aortic pressure.Biomedical engineering online · 2019Review
- Lumped parameter model for hemodynamic simulation of congenital heart diseases.The journal of physiological sciences : JPS · 2018Review
- A computational study of the Fontan circulation with fenestration or hepatic vein exclusion.Computers in biology and medicine · 2017Article
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4 authors.
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Abstract
This paper is concerned with the mathematical modeling of a severe and common congenital defect called hypoplastic left heart syndrome (HLHS). Surgical approaches are utilized for palliating this heart condition; however, a brain white matter injury called periventricular leukomalacia (PVL) occurs with high prevalence at or around the time of surgery, the exact cause of which is not known presently. Our main goal in this paper is to study the hemodynamic conditions under which HLHS physiology may lead to the occurrence of PVL. A lumped parameter model of the HLHS circulation has been developed integrating diffusion modeling of oxygen and carbon dioxide concentrations in order to study hemodynamic variables such as pressure, flow, and blood gas concentration. Results presented include calculations of blood pressures and flow rates in different parts of the circulation. Simulations also show changes in the ratio of pulmonary to systemic blood flow rates when the sizes of the patent ductus arteriosus and atrial septal defect are varied. These changes lead to unbalanced blood circulations and, when combined with low oxygen and carbon dioxide concentrations in arteries, result in poor oxygen delivery to the brain. We stipulate that PVL occurs as a consequence.
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