ArticleAdvanced biomedical research2015
In silico prediction of B- and T- cell epitope on Lassa virus proteins for peptide based subunit vaccine design.
Article in Advanced biomedical research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 20 citations in OpenAlex.
- In-silico investigations of bioactive compounds from ginger against Lassa fever virus nucleoprotein.Scientific reports · 2025Article
- Identification of Common CD8Journal of virology · 2020Article
- In-silico identification of the vaccine candidate epitopes against the Lassa virus hemorrhagic fever.Scientific reports · 2020Article
- Inter-Lineage Variation of Lassa Virus Glycoprotein Epitopes: A Challenge to Lassa Virus Vaccine Development.Viruses · 2020Review
- Exploring Lassa Virus Proteome to Design a Multi-epitope Vaccine Through Immunoinformatics and Immune Simulation Analyses.International journal of peptide research and therapeutics · 2020Article
- Epitope Prediction by Novel Immunoinformatics Approach: A State-of-the-art Review.International journal of peptide research and therapeutics · 2020Review
- Vaccine design of coronavirus spike (S) glycoprotein in chicken: immunoinformatics and computational approaches.Translational medicine communications · 2020Article
- The Immunogenicity of OMP31 Peptides and Its Protection Against Brucella melitensis Infection in Mice.Scientific reports · 2019Article
- Computer aided epitope design as a peptide vaccine component against Lassa virus.Bioinformation · 2017Article
- In silico-based vaccine design against Ebola virus glycoprotein.Advances and applications in bioinformatics and chemistry : AABC · 2017Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLassa fever is a severe, often-fatal and one of the most virulent disease in primates. However, the mechanism of escape of virus from the T-cell mediated immune response of the host cell is not explained in any studies yet. In our studies we had aimed to predict B- and T- cell epitope of Lassa virus protein, for impaling the futuristic approach of developing preventive measures against this disease, further we can also study its presumed viral- host mechanism. MATERIALS AND
methodsPeptide based subunit vaccine was developed from all four protein against Lassa virus. We adopted sequence, 3D structure and fold level in silico analysis to predict B-cell and T-cell epitopes. The 3-D structure was determined for all protein by homology modeling and the modeled structure validated.
resultsOne T-cell epitope from Glycoprotein (WDCIMTSYQ) and one from Nucleoprotein (WPYIASRTS) binds to maximum no of MHC class I and MHC class II alleles. They also specially bind to HLA alleles namely, A*0201, A*2705, DRB*0101 and DRB*0401.
conclusionsTaken together, the results indicate the Glycoprotein and nucleoprotein are most suitable vaccine candidates against Lassa virus.
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