ArticleBiomedical optics express2015
Mitochondrial swelling and restorable fragmentation stimulated by femtosecond laser.
Article in Biomedical optics express, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed.
- Real-Time and Site-Specific Perturbation of Dynamic Subcellular Compartments Using Femtosecond Pulses.Small science · 2025Article
- Article
- Real-time precision opto-control of chemical processes in live cells.Nature communications · 2022Article
- Temperature and depth evaluation of the in vitro effects of femtosecond laser on oral soft tissue, with or without air-cooling.Lasers in medical science · 2019Article
- Prophylactic application of laser light restores L-FABP expression in the livers of rats submitted to partial ischemia.Clinics (Sao Paulo, Brazil) · 2018Article
- Molecular response of mitochondria to a short-duration femtosecond-laser stimulation.Biomedical optics express · 2017Article
- Dendritic mitoflash as a putative signal for stabilizing long-term synaptic plasticity.Nature communications · 2017Article
- Photothermal imaging of skeletal muscle mitochondria.Biomedical optics express · 2017Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mitochondria play a key role in all cellular physiology, processes, and behaviors. It is very difficult to precisely stimulate single mitochondria noninvasively in traditional biomedical research. In this study, we report that femtosecond laser can stimulate fragmentation or swelling of single mitochondria in human mesenchymal stem cells rather than physical disruption or ablation. In experiments, fragmented mitochondria can recover normal very soon but swelling ones cannot. At the same time, laser-induced generation of mitochondrial reactive oxygen species and opening of mitochondria permeability transition pores are involved in mitochondrial responses to photostimulation. Furthermore, the localized translocation of proapoptotic molecules are found in those stimulated mitochondria. Those results suggest femtosecond-laser photostimulation as a noninvasive and precise method for mitochondrial manipulation and related research.
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Registered trials
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