ArticleBiomedical optics express2015
Label-free assessment of replicative senescence in mesenchymal stem cells by Raman microspectroscopy.
Article in Biomedical optics express, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 23 citations in OpenAlex.
- Raman Spectroscopy in Cellular and Tissue Aging Research.Aging cell · 2025Review
- Coherent Raman microscopy visualizes ongoing cellular senescence through amide I peak shifts originating from β sheets in disordered nucleolar proteins.Scientific reports · 2024Article
- Morphology-based deep learning enables accurate detection of senescence in mesenchymal stem cell cultures.BMC biology · 2024Article
- Raman spectroscopy to assess the differentiation of bone marrow mesenchymal stem cells into a glial phenotype.Regenerative therapy · 2023Article
- Review
- Noninvasive morpho-molecular imaging reveals early therapy-induced senescence in human cancer cells.Science advances · 2023Article
- Deep ensemble learning and transfer learning methods for classification of senescent cells from nonlinear optical microscopy images.Frontiers in chemistry · 2023Article
- Multimodal Autoencoder Predicts fNIRS Resting State From EEG Signals.Neuroinformatics · 2022Article
- Review
- Anti-senescence effect and molecular mechanism of the major royal jelly proteins on human embryonic lung fibroblast (HFL-I) cell line.Journal of Zhejiang University. Science. BArticle
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Here, Raman microspectroscopy was employed to assess replicative senescence of mesenchymal stem cells (MSC). A regular spectral change related to the cell senescence was found in the ratio of two peaks at 1157 cm(-1) and 1174 cm(-1), which are assigned to C-C, C-N stretching vibrations in proteins and C-H bending vibrations in tyrosine and phenylalanine, respectively. With the cell aging, the ratio I1157 / I1174 exhibited a monotonic decline and showed small standard deviations, so that it can statistically distinguish between cells having slight changes in terms of aging. We propose that I1157 / I1174 can act as a characteristic spectral signature for label-free assessment of MSC senescence.
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Registered trials
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