ArticleBiomedical optics express2015
Effect of recombinant interleukin-12 on murine skin regeneration and cell dynamics using in vivo multimodal microscopy.
Article in Biomedical optics express, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- Optical, Tomographic, and Mass Spectrometry Imaging Methods for Burn Wounds: Capabilities, Limitations, and Clinical Potential.Biomedicines · 2026Review
- Real-time, high-resolution metabolic characterization of live bacteria using label-free optical metabolic imaging.NPJ biofilms and microbiomes · 2026Article
- Adipose-Derived Stem Cells' Secretome Attenuates Lesion Size and Parasite Loading in Leishmaniasis Caused byIranian journal of medical sciences · 2024Article
- Effect of cold atmospheric microwave plasma (CAMP) on wound healing in canine keratinocytes.Frontiers in cell and developmental biology · 2023Article
- 3D in vitro M2 macrophage model to mimic modulation of tissue repair.NPJ Regenerative medicine · 2021Article
- Tissue-level cytokines in a rodent model of chronic implant-associated infection.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2021Article
- Label-Free Multimodal Multiphoton Intravital Imaging.Advances in experimental medicine and biology · 2021Article
- Video-rate multimodal multiphoton imaging and three-dimensional characterization of cellular dynamics in wounded skin.Journal of innovative optical health sciences · 2020Article
- Quantitative Analysis on Ex Vivo Nonlinear Microscopy Images of Basal Cell Carcinoma Samples in Comparison to Healthy Skin.Pathology oncology research : POR · 2019Article
- Immuno-modulatory effect of local rhEGF treatment during tissue repair in diabetic ulcers.Endocrine connections · 2018Article
- Investigating the healing mechanisms of an angiogenesis-promoting topical treatment for diabetic wounds using multimodal microscopy.Journal of biophotonics · 2018Article
- In vivo multiphoton microscopy detects longitudinal metabolic changes associated with delayed skin wound healing.Communications biology · 2018Article
- Article
- In vivo evaluation of adipose- and muscle-derived stem cells as a treatment for nonhealing diabetic wounds using multimodal microscopy.Journal of biomedical optics · 2016Article
- Moxifloxacin: Clinically compatible contrast agent for multiphoton imaging.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Interleukin-12 (IL-12) is a pro-inflammatory cytokine known for its role in immunity, and previous studies have shown that IL-12 provides mitigation of radiation injury. In this study, we utilize a multimodal microscopy system equipped with second harmonic generation (SHG) and fluorescence lifetime imaging microscopy (FLIM) to examine the effect of IL-12 on collagen structure and cellular metabolic activity in vivo during skin wound healing. This preliminary study illustrates the highly dynamic and heterogeneous in vivo microenvironment of the wounded skin. In addition, results suggest that IL-12 triggers a significantly more rapid and greater cellular metabolic response in the wounded animals. These results can elucidate insights into the response mechanism of IL-12 in both wound healing and acute radiation syndrome.
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